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01-06-2004 | Editorial

Hyperbaric oxygen in systemic inflammatory response

Authors: Haim Bitterman, Claus-Martin Muth

Published in: Intensive Care Medicine | Issue 6/2004

Excerpt

In this issue of Intensive Care Medicine, Dr. Imperatore and coworkers [1] present their data on the beneficial effects of hyperbaric oxygen (HBO) in a rat model of systemic inflammatory response (SIR) and circulatory shock induced by intraperitoneal injection of zymosan. In their study, HBO therapy prevented hypotension and shock in zymosan-treated rats and improved the impaired response of aortic rings to norepinephrine and acetylcholine ex vivo. Furthermore, HBO decreased the accumulation of malondialdehyde (MDA) (a marker of lipid peroxidation) and reduced tissue staining for iNOS and nitrotyrosine (a marker of “nitrosative stress”) in the aorta. This report follows previous studies of the same group in which they reported that HBO therapy given after injection of zymosan decreased symptomatology, increased survival, reduced peritoneal inflammation and peritoneal accumulation of NO metabolites, attenuated the increase in tissue levels of myeloperoxidase (MPO) and MDA in the lung liver and intestine, and attenuated plasma accumulation of TNF-α [2, 3]. …

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Title: Hyperbaric oxygen in systemic inflammatory response
Authors: Haim Bitterman
Claus-Martin Muth
Publication date: 01-06-2004
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 6/2004
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-004-2211-y

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