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Acta Neurochirurgica

Published in:

29-08-2023 | Hydrocephalus | Review Article

CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review

Authors: Shai David Ben-Shoshan, Sara Diana Lolansen, Tiit Illimar Mathiesen, Nanna MacAulay

Published in: Acta Neurochirurgica | Issue 11/2023

Abstract

Background

The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) remain elusive. The aim of this systematic review was to evaluate existing literature on increased CSF secretion and impaired CSF absorption as pathogenic contributors to CSF accumulation in neonatal and adult PHH.

Methods

The systematic review was conducted in accordance with the PRISMA guidelines. Relevant studies published before March 11th, 2023, were identified from PubMed and reference lists. Studies were screened for eligibility using predefined inclusion and exclusion criteria. Data from eligible studies were extracted and potential sources of bias were evaluated.

Results

Nineteen studies quantified CSF production rates and/or CSF absorption capacity in human patients with PHH or animals with experimentally induced PHH. Increased CSF production was reported as early as 24 h and as late as 28 days post ictus in six out of eight studies quantifying CSF production rates in animals with experimentally induced PHH. Impaired CSF absorption was reported in all four studies quantifying CSF absorption capacity in human patients with PHH and in seven out of nine studies quantifying CSF absorption capacity in animals with experimentally induced PHH. Impaired CSF absorption was reported as early as 30 min and as late as 10 months post ictus.

Conclusions

The pathological CSF accumulation in PHH likely arises from a combination of increased CSF secretion and impaired CSF absorption, which may manifest at different time scales following a hemorrhagic event. Emergent evidence on increased CSF secretion by the choroid plexus may herald a paradigm shift in our understanding of PHH.

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Title: CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review
Authors: Shai David Ben-Shoshan
Sara Diana Lolansen
Tiit Illimar Mathiesen
Nanna MacAulay
Publication date: 29-08-2023
Publisher: Springer Vienna
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Subarachnoid Hemorrhage
Subarachnoid Hemorrhage
Intracranial Hypertension
Published in: Acta Neurochirurgica / Issue 11/2023
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-023-05746-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

CSF hypersecretion versus impaired CSF absorption in posthemorrhagic hydrocephalus: a systematic review

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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