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Virology Journal
Published in: Virology Journal 1/2019

Open Access 01-12-2019 | Human Papillomavirus | Research

Serum and tissue miRNAs: potential biomarkers for the diagnosis of cervical cancer

Authors: Mahdieh Farzanehpour, Sayed-Hamidreza Mozhgani, Somayeh Jalilvand, Ebrahim Faghihloo, Setareh Akhavan, Vahid Salimi, Talat Mokhtari Azad

Published in: Virology Journal | Issue 1/2019

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Abstract

Background

Finding new biomarkers for the early detection of cervical cancer is an essential requirement in this field. In this study, we aimed to evaluate the expression level of potential biomarkers in progression of cervical cancer in patients with cervical cancer compared to normal subjects.

Methods

The expression levels of tissue and serum miRNAs, including miR-9, miR-192 and miR-205, were investigated in 36 normal, 18 precancer, and 18 cervical cancer samples using real-time polymerase chain reaction.

Results

The results showed the higher significant expressions of miR-9, miR-192 and miR-205 in the tissue of cancer samples than those in the normal samples. Moreover, the miR-192 and miR-205 expression were significantly increased in the cancer group in comparison with the precancer group. Examination of serum samples revealed the increase in the expression level in the cancer groups than in the normal samples, for miR-9, miR-192 and miR-205 and the expressions of miR-9, miR-192 and miR-205 were significantly up-regulated in the precancer group in comparison with the normal group. Also the expression of miR-205 was remarkably increased in the cancer group in comparison with the precancer group. The receiver operating characteristic (ROC) analyses showed the highest area under the curve value for miR-192.

Conclusions

Given the increased expression level of miR-192 in cancer and in precancerous tissue and serum compared with the normal tissue and serum validated by analysing the ROC curve, miR-192 can be used as potential biomarker for the early detection of cervical cancer.
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Metadata
Title
Serum and tissue miRNAs: potential biomarkers for the diagnosis of cervical cancer
Authors
Mahdieh Farzanehpour
Sayed-Hamidreza Mozhgani
Somayeh Jalilvand
Ebrahim Faghihloo
Setareh Akhavan
Vahid Salimi
Talat Mokhtari Azad
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2019
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/s12985-019-1220-y

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Keynote webinar | Spotlight on medication adherence

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Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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