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AIDS and Behavior
Published in: AIDS and Behavior 8/2019

01-08-2019 | Human Immunodeficiency Virus | Original Paper

The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)

Authors: Cenk Yildirim, Patricia A. Garvie, Miriam Chernoff, Megan L. Wilkins, E. Doyle Patton, Paige L. Williams, Sharon L. Nichols, for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study

Published in: AIDS and Behavior | Issue 8/2019

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Abstract

Antiretroviral (ARV) adherence is critical in monitoring disease response in youth with perinatally-acquired HIV (PHIV). We used pharmacy refill (PR) information for PHIV youth from the PHACS Memory Sub-study to calculate medication availability over 2, 4, and 6 months. PR, a proxy of adherence, was compared with self-reported 7-day adherence in predicting suppressed viral load (SVL < 400 copies/mL) and higher CD4% (≥ 25%). Among 159 PHIV youth, 79% were adherent by 7-day recall, and 62, 55, and 48% by PR over 2, 4, and 6 months, respectively. Agreement between 7-day recall and PR adherence was weak (Kappa = 0.09–0.25). In adjusted logistic regression models, adherence showed associations with SVL for 7-day recall (OR 2.78, 95% CI 1.08, 7.15) and all PR coverage periods (6-month: OR 3.24, 95% CI 1.22, 8.65). Similar associations were observed with higher CD4%. PR measures were predictive of study retention. Findings suggest a possibly independent role of PR adherence measures.
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Metadata
Title
The Role of Pharmacy Refill Measures in Assessing Adherence and Predicting HIV Disease Markers in Youth with Perinatally-Acquired HIV (PHIV)
Authors
Cenk Yildirim
Patricia A. Garvie
Miriam Chernoff
Megan L. Wilkins
E. Doyle Patton
Paige L. Williams
Sharon L. Nichols
for the Memory and Executive Functioning Study of the Pediatric HIV/AIDS Cohort Study
Publication date
01-08-2019
Publisher
Springer US
Published in
AIDS and Behavior / Issue 8/2019
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-019-02468-x

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