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01-08-2019 | Human Immunodeficiency Virus

Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure

Authors: Adam R. Denton, Srimal A. Samaranayake, Kristin N. Kirchner, Robert F. Roscoe Jr, Shane N. Berger, Steven B. Harrod, Charles F. Mactutus, Parastoo Hashemi, Rosemarie M. Booze

Published in: Journal of NeuroVirology | Issue 4/2019

Abstract

Between 30 and 60% of HIV-seropositive individuals develop symptoms of clinical depression and/or apathy. Dopamine and serotonin are associated with motivational alterations; however, histamine is less well studied. In the present study, we used fast-scan cyclic voltammetry in HIV-1 transgenic (Tg) rats to simultaneously analyze the kinetics of nucleus accumbens dopamine (DA), prefrontal cortical serotonin (5-HT), and hypothalamic histamine (HA). For voltammetry, subjects were 15 HIV-1 Tg (7 male, 8 female) and 20 F344/N (11 male, 9 female) adult rats. Both serotonergic and dopaminergic release and reuptake kinetics were decreased in HIV-1 Tg animals relative to controls. In contrast, rates of histamine release and reuptake increased in HIV-1 Tg rats. Additionally, we used immunohistochemical (IHC) methods to identify histaminergic neurons in the tuberomammillary nucleus (TMN) of the hypothalamus. For IHC, subjects were 9 HIV-1 Tg (5 male, 4 female) and 9 F344/N (5 male, 4 female) adult rats. Although the total number of TMN histaminergic cells did not differ between HIV-1 Tg rats and F344/N controls, a significant sex effect was found, with females having an increased number of histaminergic neurons, relative to males. Collectively, these findings illustrate neurochemical alterations that potentially underlie or exacerbate the pathogenesis of clinical depression and/or apathy in HIV-1.

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Title: Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure
Authors: Adam R. Denton
Srimal A. Samaranayake
Kristin N. Kirchner
Robert F. Roscoe Jr
Shane N. Berger
Steven B. Harrod
Charles F. Mactutus
Parastoo Hashemi
Rosemarie M. Booze
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keyword: Human Immunodeficiency Virus
Published in: Journal of NeuroVirology / Issue 4/2019
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-019-00754-x

At a glance: The STEP trials

Springer Medicine

Selective monoaminergic and histaminergic circuit dysregulation following long-term HIV-1 protein exposure

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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