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Keynote webinar | Spotlight on medication adherence

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Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
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AIDS Research and Therapy
Published in: AIDS Research and Therapy 1/2020

Open Access 01-12-2020 | Human Immunodeficiency Virus | Case Report

Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring

Authors: Kennedy Michael Ngowi, Lydia Masika, Furaha Lyamuya, Eva Muro, Blandina T. Mmbaga, Mirjam A. G. Sprangers, Pythia T. Nieuwkerk, Rob E. Aarnoutse, Peter Reiss, I. Marion Sumari-de Boer

Published in: AIDS Research and Therapy | Issue 1/2020

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Abstract

Real-time medication monitoring (RTMM) may potentially enhance adherence to antiretroviral treatment (ART). We describe a participant in an ongoing trial who, shortly after completing trial participation, died of cryptococcal meningitis despite high levels of adherence according to self-report, pill-counts and RTMM (> 99%). However, she evidenced consistently high HIV viral load throughout the 48-week study follow-up. Subsequently, her relatives unsolicitedly returned eight months’ dispensed ART medication that she was supposed to have taken. This brief report illustrates the challenges of adherence measurements including RTMM, and reinforces the need to combine adherence assessments with viral load monitoring in HIV care.
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Metadata
Title
Returning of antiretroviral medication dispensed over a period of 8 months suggests non-adherence despite full adherence according to real time medication monitoring
Authors
Kennedy Michael Ngowi
Lydia Masika
Furaha Lyamuya
Eva Muro
Blandina T. Mmbaga
Mirjam A. G. Sprangers
Pythia T. Nieuwkerk
Rob E. Aarnoutse
Peter Reiss
I. Marion Sumari-de Boer
Publication date
01-12-2020
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2020
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/s12981-020-00313-z

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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