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Published in: AIDS and Behavior 5/2021

01-05-2021 | Human Immunodeficiency Virus | Original Paper

Survival Outcomes of Vietnamese People with HIV after Initiating Antiretroviral Treatment: Role of Clinic-Related Factors

Authors: Nhien Thi Hoang, Nguyen Thao Thi Nguyen, Quang Nhat Nguyen, John W. Bollinger, Bach Xuan Tran, Nhan Thi Do, Trang Huyen Thi Nguyen, Huong Lan Thi Nguyen, Trang Ha Nguyen, Carl A. Latkin, Cyrus S. H. Ho, Roger C. M. Ho

Published in: AIDS and Behavior | Issue 5/2021

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Abstract

Given the rapid development of HIV clinics in Vietnam, this study evaluates the infrastructure surrounding this expansion, identifying clinic-related factors that impact survival outcomes. A retrospective longitudinal study was conducted among people living with HIV (PLWH) who initiated antiretroviral therapy (ART) between 2011 and 2015 among 62 ART clinics in 15 provinces. The mortality rate during the 717674.1 person-years of observation (PYO) was 0.29/100 PYO. Location in rural areas (versus urban) and in Central Vietnam (versus Northern Vietnam) were associated with higher risk of mortality. The risk was lower among clinics that had peer-educators. As Vietnam’s HIV/AIDS program continues to expand, this data supports increasing resource allocation for rural clinics, incorporation of ART with the community’s existing healthcare infrastructure in its efforts to decentralize, and integration of services to reflect patients’ anticipated needs.
Literature
1.
go back to reference Reniers G, Araya T, Davey G, et al. Steep declines in population-level AIDS mortality following the introduction of antiretroviral therapy in Addis Ababa, Ethiopia. AIDS. 2009;23(4):511–8.CrossRef Reniers G, Araya T, Davey G, et al. Steep declines in population-level AIDS mortality following the introduction of antiretroviral therapy in Addis Ababa, Ethiopia. AIDS. 2009;23(4):511–8.CrossRef
2.
go back to reference De La Mata NL, Kumarasamy N, Khol V, et al. Improved survival in HIV treatment programmes in Asia. Antivir Ther. 2016;21(6):517–27.CrossRef De La Mata NL, Kumarasamy N, Khol V, et al. Improved survival in HIV treatment programmes in Asia. Antivir Ther. 2016;21(6):517–27.CrossRef
3.
go back to reference Boulle A, Schomaker M, May MT, et al. Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies. PLoS Med. 2014;11(9):e1001718.CrossRef Boulle A, Schomaker M, May MT, et al. Mortality in patients with HIV-1 infection starting antiretroviral therapy in South Africa, Europe, or North America: a collaborative analysis of prospective studies. PLoS Med. 2014;11(9):e1001718.CrossRef
4.
go back to reference Tanuma J, Lee KH, Haneuse S, et al. Incidence of AIDS-defining opportunistic infections and mortality during antiretroviral therapy in a cohort of adult HIV-infected individuals in Hanoi, 2007–2014. PloS One. 2016a;11(3):e0150781.CrossRef Tanuma J, Lee KH, Haneuse S, et al. Incidence of AIDS-defining opportunistic infections and mortality during antiretroviral therapy in a cohort of adult HIV-infected individuals in Hanoi, 2007–2014. PloS One. 2016a;11(3):e0150781.CrossRef
5.
go back to reference Tran DA, Shakeshaft A, Ngo AD, et al. Determinants of antiretroviral therapy initiation and treatment outcomes for people living with HIV in Vietnam. HIV Clin Trials. 2013;14(1):21–33.CrossRef Tran DA, Shakeshaft A, Ngo AD, et al. Determinants of antiretroviral therapy initiation and treatment outcomes for people living with HIV in Vietnam. HIV Clin Trials. 2013;14(1):21–33.CrossRef
7.
go back to reference Hirnschall G, Schwartländer B. Treatment 2.0: catalysing the next phase of scale-up. Lancet. 2011;378(9787):209–11.CrossRef Hirnschall G, Schwartländer B. Treatment 2.0: catalysing the next phase of scale-up. Lancet. 2011;378(9787):209–11.CrossRef
9.
go back to reference Nguyen QLT, Nguyen LH, Tran BX, et al. Co-financing for viral load monitoring during the course of antiretroviral therapy among patients with HIV/AIDS in Vietnam: a contingent valuation survey. PLoS One. 2017;12(2):e0172050–e0172050.CrossRef Nguyen QLT, Nguyen LH, Tran BX, et al. Co-financing for viral load monitoring during the course of antiretroviral therapy among patients with HIV/AIDS in Vietnam: a contingent valuation survey. PLoS One. 2017;12(2):e0172050–e0172050.CrossRef
10.
go back to reference Tran BX, Than PQT, Tran TT, Nguyen CT, Latkin CA. Changing sources of stigma against patients with HIV/AIDS in the rapid expansion of antiretroviral treatment services in Vietnam. Biomed Res Int. 2019;2019:4208638.PubMedPubMedCentral Tran BX, Than PQT, Tran TT, Nguyen CT, Latkin CA. Changing sources of stigma against patients with HIV/AIDS in the rapid expansion of antiretroviral treatment services in Vietnam. Biomed Res Int. 2019;2019:4208638.PubMedPubMedCentral
11.
go back to reference Van Tam V, Pharris A, Thorson A, Alfven T, Larsson M. “It is not that I forget, it’s just that I don’t want other people to know”: barriers to and strategies for adherence to antiretroviral therapy among HIV patients in Northern Vietnam. AIDS Care. 2011;23(2):139–45.CrossRef Van Tam V, Pharris A, Thorson A, Alfven T, Larsson M. “It is not that I forget, it’s just that I don’t want other people to know”: barriers to and strategies for adherence to antiretroviral therapy among HIV patients in Northern Vietnam. AIDS Care. 2011;23(2):139–45.CrossRef
12.
go back to reference Rangarajan S, Tram HN, Todd CS, et al. Risk factors for delayed entrance into care after diagnosis among patients with late-stage HIV disease in southern Vietnam. PLoS One. 2014;9(10):e108939.CrossRef Rangarajan S, Tram HN, Todd CS, et al. Risk factors for delayed entrance into care after diagnosis among patients with late-stage HIV disease in southern Vietnam. PLoS One. 2014;9(10):e108939.CrossRef
13.
go back to reference Handford CD, Rackal JM, Tynan A-M, Rzeznikiewiz D, Glazier RH. The association of hospital, clinic and provider volume with HIV/AIDS care and mortality: systematic review and meta-analysis. AIDS Care. 2012;24(3):267–82.CrossRef Handford CD, Rackal JM, Tynan A-M, Rzeznikiewiz D, Glazier RH. The association of hospital, clinic and provider volume with HIV/AIDS care and mortality: systematic review and meta-analysis. AIDS Care. 2012;24(3):267–82.CrossRef
14.
go back to reference Holmes CB, Sikazwe I, Sikombe K, et al. Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: findings from a multistage sampling-based survey. PLoS Med. 2018;15(1):e1002489.CrossRef Holmes CB, Sikazwe I, Sikombe K, et al. Estimated mortality on HIV treatment among active patients and patients lost to follow-up in 4 provinces of Zambia: findings from a multistage sampling-based survey. PLoS Med. 2018;15(1):e1002489.CrossRef
15.
go back to reference Nguyen QLT, Van Phan T, Tran BX, et al. Health insurance for patients with HIV/AIDS in Vietnam: coverage and barriers. BMC Health Serv Res. 2017;17(1):519–519.CrossRef Nguyen QLT, Van Phan T, Tran BX, et al. Health insurance for patients with HIV/AIDS in Vietnam: coverage and barriers. BMC Health Serv Res. 2017;17(1):519–519.CrossRef
16.
go back to reference Tanuma J, Lee KH, Haneuse S, et al. Incidence of AIDS-defining opportunistic infections and mortality during antiretroviral therapy in a cohort of adult HIV-infected individuals in Hanoi, 2007–2014. PLoS One. 2016b;11(3):e0150781–e0150781.CrossRef Tanuma J, Lee KH, Haneuse S, et al. Incidence of AIDS-defining opportunistic infections and mortality during antiretroviral therapy in a cohort of adult HIV-infected individuals in Hanoi, 2007–2014. PLoS One. 2016b;11(3):e0150781–e0150781.CrossRef
17.
go back to reference Beckham SW, Beyrer C, Luckow P, Doherty M, Negussie EK, Baral SD. Marked sex differences in all-cause mortality on antiretroviral therapy in low- and middle-income countries: a systematic review and meta-analysis. J Int AIDS Soc. 2016;19(1):21106–21106.CrossRef Beckham SW, Beyrer C, Luckow P, Doherty M, Negussie EK, Baral SD. Marked sex differences in all-cause mortality on antiretroviral therapy in low- and middle-income countries: a systematic review and meta-analysis. J Int AIDS Soc. 2016;19(1):21106–21106.CrossRef
18.
go back to reference Edwards JK, Cole SR, Westreich D, et al. Age at entry into care, timing of antiretroviral therapy initiation, and 10-year mortality among HIV-seropositive adults in the United States. Clin Infect Dis. 2015;61(7):1189–95.CrossRef Edwards JK, Cole SR, Westreich D, et al. Age at entry into care, timing of antiretroviral therapy initiation, and 10-year mortality among HIV-seropositive adults in the United States. Clin Infect Dis. 2015;61(7):1189–95.CrossRef
19.
go back to reference Otwombe KN, Petzold M, Modisenyane T, Martinson NA, Chirwa T. Factors associated with mortality in HIV-infected people in rural and urban South Africa. Global Health Action. 2014;7:25488–25488.CrossRef Otwombe KN, Petzold M, Modisenyane T, Martinson NA, Chirwa T. Factors associated with mortality in HIV-infected people in rural and urban South Africa. Global Health Action. 2014;7:25488–25488.CrossRef
20.
go back to reference Do TN, Nguyen TMT, Do MH, et al. Combining cohort analysis and monitoring of HIV early-warning indicators of drug resistance to assess antiretroviral therapy services in Vietnam. Clin Infect Dis. 2012;54(suppl_4):S306–12.CrossRef Do TN, Nguyen TMT, Do MH, et al. Combining cohort analysis and monitoring of HIV early-warning indicators of drug resistance to assess antiretroviral therapy services in Vietnam. Clin Infect Dis. 2012;54(suppl_4):S306–12.CrossRef
21.
go back to reference Tran BX, Nguyen NPT. Patient satisfaction with HIV/AIDS care and treatment in the decentralization of services delivery in Vietnam. PLoS One. 2012;7(10):e46680–e46680.CrossRef Tran BX, Nguyen NPT. Patient satisfaction with HIV/AIDS care and treatment in the decentralization of services delivery in Vietnam. PLoS One. 2012;7(10):e46680–e46680.CrossRef
22.
go back to reference Tat S, Barr D. Healthcare in the New Vietnam: comparing patients’ satisfaction with outpatient care in a traditional neighborhood clinic and a new, western-style clinic in Ho Chi Minh City. Soc Sci Med. 2006;62(5):1229–36.CrossRef Tat S, Barr D. Healthcare in the New Vietnam: comparing patients’ satisfaction with outpatient care in a traditional neighborhood clinic and a new, western-style clinic in Ho Chi Minh City. Soc Sci Med. 2006;62(5):1229–36.CrossRef
23.
go back to reference Tran BX, Dang AK, Vu GT, et al. Patient satisfaction with HIV services in Vietnam: status, service models and association with treatment outcome. PLoS One. 2019;14(11):e0223723.CrossRef Tran BX, Dang AK, Vu GT, et al. Patient satisfaction with HIV services in Vietnam: status, service models and association with treatment outcome. PLoS One. 2019;14(11):e0223723.CrossRef
24.
go back to reference Tran BX. Quality of life outcomes of antiretroviral treatment for HIV/AIDS patients in Vietnam. PLoS One. 2012;7(7):e41062–e41062.CrossRef Tran BX. Quality of life outcomes of antiretroviral treatment for HIV/AIDS patients in Vietnam. PLoS One. 2012;7(7):e41062–e41062.CrossRef
25.
go back to reference Lambdin BH, Micek MA, Sherr K, et al. Integration of HIV care and treatment in primary health care centers and patient retention in central Mozambique: a retrospective cohort study. J Acquir Immune Defic Syndr. 2013;62(5):e146–52.CrossRef Lambdin BH, Micek MA, Sherr K, et al. Integration of HIV care and treatment in primary health care centers and patient retention in central Mozambique: a retrospective cohort study. J Acquir Immune Defic Syndr. 2013;62(5):e146–52.CrossRef
26.
go back to reference Keitz SA, Box TL, Homan RK, Bartlett JA, Oddone EZ. Primary care for patients infected with human immunodeficiency virus: a randomized controlled trial. J Gen Intern Med. 2001;16(9):573–82.CrossRef Keitz SA, Box TL, Homan RK, Bartlett JA, Oddone EZ. Primary care for patients infected with human immunodeficiency virus: a randomized controlled trial. J Gen Intern Med. 2001;16(9):573–82.CrossRef
27.
go back to reference Mai HT, Le GM, Tran BX, et al. Adherence to antiretroviral therapy among HIV/AIDS patients in the context of early treatment initiation in Vietnam. Patient Prefer Adher. 2018;12:2131.CrossRef Mai HT, Le GM, Tran BX, et al. Adherence to antiretroviral therapy among HIV/AIDS patients in the context of early treatment initiation in Vietnam. Patient Prefer Adher. 2018;12:2131.CrossRef
28.
go back to reference Tran BX, Hoang CL, Tam W, et al. A global bibliometric analysis of antiretroviral treatment adherence: implications for interventions and research development (GAPRESEARCH). AIDS Care. 2020;32(5):637–44.CrossRef Tran BX, Hoang CL, Tam W, et al. A global bibliometric analysis of antiretroviral treatment adherence: implications for interventions and research development (GAPRESEARCH). AIDS Care. 2020;32(5):637–44.CrossRef
29.
go back to reference Frasca K, Cohn J. Integration of HIV and tuberculosis in the community. J Int Assoc Provid AIDS Care (JIAPAC). 2014;13(6):534–8.CrossRef Frasca K, Cohn J. Integration of HIV and tuberculosis in the community. J Int Assoc Provid AIDS Care (JIAPAC). 2014;13(6):534–8.CrossRef
30.
go back to reference Manosuthi W, Wiboonchutikul S, Sungkanuparph S. Integrated therapy for HIV and tuberculosis. AIDS Res Ther. 2016;13(1):22.CrossRef Manosuthi W, Wiboonchutikul S, Sungkanuparph S. Integrated therapy for HIV and tuberculosis. AIDS Res Ther. 2016;13(1):22.CrossRef
31.
go back to reference Tran BX, Nguyen LH, Nong VM, Nguyen CT, Phan HTT, Latkin CA. Behavioral and quality-of-life outcomes in different service models for methadone maintenance treatment in Vietnam. Harm Reduct J. 2016;13(1):4.CrossRef Tran BX, Nguyen LH, Nong VM, Nguyen CT, Phan HTT, Latkin CA. Behavioral and quality-of-life outcomes in different service models for methadone maintenance treatment in Vietnam. Harm Reduct J. 2016;13(1):4.CrossRef
32.
go back to reference Tran BX, Nguyen LH, Phan HTT, Latkin CA. Patient satisfaction with methadone maintenance treatment in Vietnam: a comparison of different integrative-service delivery models. PLoS One. 2015;10(11):e0142644.CrossRef Tran BX, Nguyen LH, Phan HTT, Latkin CA. Patient satisfaction with methadone maintenance treatment in Vietnam: a comparison of different integrative-service delivery models. PLoS One. 2015;10(11):e0142644.CrossRef
33.
go back to reference Than PQT, Tran BX, Nguyen CT, et al. Stigma against patients with HIV/AIDS in the rapid expansion of antiretroviral treatment in large drug injection-driven HIV epidemics of Vietnam. Harm Reduct J. 2019;16(1):6.CrossRef Than PQT, Tran BX, Nguyen CT, et al. Stigma against patients with HIV/AIDS in the rapid expansion of antiretroviral treatment in large drug injection-driven HIV epidemics of Vietnam. Harm Reduct J. 2019;16(1):6.CrossRef
34.
go back to reference Kato M, Granich R, Bui DD, et al. The potential impact of expanding antiretroviral therapy and combination prevention in Vietnam: towards elimination of HIV transmission. J Acquir Immune Defic Syndr. 2013;63(5):e142–9.CrossRef Kato M, Granich R, Bui DD, et al. The potential impact of expanding antiretroviral therapy and combination prevention in Vietnam: towards elimination of HIV transmission. J Acquir Immune Defic Syndr. 2013;63(5):e142–9.CrossRef
35.
go back to reference Vu TMT, Boggiano VL, Tran BX, et al. Sexual risk behaviors of patients with HIV/AIDS over the course of antiretroviral treatment in Northern Vietnam. Int J Environ Res Public Health. 2018;15(6):1106.CrossRef Vu TMT, Boggiano VL, Tran BX, et al. Sexual risk behaviors of patients with HIV/AIDS over the course of antiretroviral treatment in Northern Vietnam. Int J Environ Res Public Health. 2018;15(6):1106.CrossRef
36.
go back to reference Nguyen TMT, Tran BX, Fleming M, et al. HIV knowledge and risk behaviors among drug users in three Vietnamese mountainous provinces. Subst Abuse Trea, Prevent Policy. 2019;14(1):1–8.CrossRef Nguyen TMT, Tran BX, Fleming M, et al. HIV knowledge and risk behaviors among drug users in three Vietnamese mountainous provinces. Subst Abuse Trea, Prevent Policy. 2019;14(1):1–8.CrossRef
37.
38.
go back to reference Merson MH, O’Malley J, Serwadda D, Apisuk C. The history and challenge of HIV prevention. Lancet (London, England). 2008;372(9637):475–88.CrossRef Merson MH, O’Malley J, Serwadda D, Apisuk C. The history and challenge of HIV prevention. Lancet (London, England). 2008;372(9637):475–88.CrossRef
Metadata
Title
Survival Outcomes of Vietnamese People with HIV after Initiating Antiretroviral Treatment: Role of Clinic-Related Factors
Authors
Nhien Thi Hoang
Nguyen Thao Thi Nguyen
Quang Nhat Nguyen
John W. Bollinger
Bach Xuan Tran
Nhan Thi Do
Trang Huyen Thi Nguyen
Huong Lan Thi Nguyen
Trang Ha Nguyen
Carl A. Latkin
Cyrus S. H. Ho
Roger C. M. Ho
Publication date
01-05-2021
Publisher
Springer US
Published in
AIDS and Behavior / Issue 5/2021
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-020-03079-7

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