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Published in: AIDS Research and Therapy 1/2022

Open Access 01-12-2022 | Human Immunodeficiency Virus | Research

Socio-demographic factors associated with medication adherence among People Living with HIV in the Kumasi Metropolis, Ghana

Authors: Collins Adu, Kofi Akohene Mensah, Bright Opoku Ahinkorah, Dorothy Osei, Andrews William Tetteh, Abdul-Aziz Seidu

Published in: AIDS Research and Therapy | Issue 1/2022

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Abstract

Background

Medication adherence is important to the survival of People Living with HIV (PLHIV) globally. Although, HIV viral load is reduced by antiretroviral therapy (ART), the number of people on ART continues to rise in Ghana. In the Kumasi Metropolis, Ghana, we looked at the socio-demographic factors associated with medication adherence among PLHIV.

Methods

A quantitative study involving 420 PLHIV who sought healthcare at the Kumasi South Regional Hospital was conducted utilizing a cross-sectional study design. We employed a structured questionnaire to collect data on medication adherence using the eight-item Morisky Medication Adherence Scale (MMAS) and socio-demographic factors that influence medication adherence. The data were analysed using Stata 14.2. Frequencies and percentages were used to present the descriptive data. The association between socio-demographic factors and medication adherence among PLHIV was investigated using both univariate and multivariate analyses.

Results

More than half (53.10%) of PLHIV adhered to ART. Place of residence was significantly established to be influencing medication adherence among PLHIV. PLHIV who were residing in urban centers (aOR = 3.61; CI = 2.24–5.82) were more likely to adhere to medication as compared to those who resided in rural areas.

Conclusion

Slightly more than half of PLHIV took their medicines as prescribed. Government and Policymakers such as the Ghana AIDS Commission, Ministry of Health, and Ghana Health Service should incorporate socio-demographic factors such as place of residence while creating and executing medication adherence initiatives to evaluate HIV management regimen for PLHIV.
Literature
5.
go back to reference Boakye DS. Adherence to antiretroviral therapy and its impact on clinical and immunologic outcomes. Ghana. 2015. Boakye DS. Adherence to antiretroviral therapy and its impact on clinical and immunologic outcomes. Ghana. 2015.
6.
go back to reference Kharsany AB, Karim QA. HIV infection and AIDS in sub-Saharan Africa: current status, challenges and opportunities. The open AIDS journal. 2022;10:34.CrossRef Kharsany AB, Karim QA. HIV infection and AIDS in sub-Saharan Africa: current status, challenges and opportunities. The open AIDS journal. 2022;10:34.CrossRef
8.
go back to reference Abingyoure AB. Dietary intake patterns and adequacy of HIV-infected adults seeking clinical care in Accra, Ghana. University of Ghana. 2013. Available at: https://ugspace.edu.gh. Abingyoure AB. Dietary intake patterns and adequacy of HIV-infected adults seeking clinical care in Accra, Ghana. University of Ghana. 2013. Available at: https://​ugspace.​edu.​gh.
11.
go back to reference Ghana Statistical Service (GSS), Ghana Health Service (GHS), ICF Macro. Ghana Demographic and Health Survey 2014 GSS, GHS, and ICF Macro, Accra, Ghana. 2015. Ghana Statistical Service (GSS), Ghana Health Service (GHS), ICF Macro. Ghana Demographic and Health Survey 2014 GSS, GHS, and ICF Macro, Accra, Ghana. 2015.
12.
go back to reference National AIDS. Control Programme. Guidelines for antiretroviral therapy in Ghana. Ghana: Accra; 2016. National AIDS. Control Programme. Guidelines for antiretroviral therapy in Ghana. Ghana: Accra; 2016.
13.
go back to reference UNAIDS. UNAIDS data 2017. Switzerland: Geneva; 2017. UNAIDS. UNAIDS data 2017. Switzerland: Geneva; 2017.
14.
go back to reference Alakija KS, Fadeji A, Ogunmodede JA, Desalu O. Factors influencing adherence to antiretroviral medication in Ilorin, Nigeria. J Int Assoc Physicians AIDS Care. 2010;9(3):191–5.CrossRef Alakija KS, Fadeji A, Ogunmodede JA, Desalu O. Factors influencing adherence to antiretroviral medication in Ilorin, Nigeria. J Int Assoc Physicians AIDS Care. 2010;9(3):191–5.CrossRef
17.
go back to reference Ankrah NAD, Koster SE, Mantel-Teeuwisse KA, Arhinful KD, Agyepong AI, Lartey M. Facilitators and barriers to antiretroviral therapy adherence among adolescents in Ghana. Patient Prefer Adherence. 2016;10:329–37.CrossRefPubMedPubMedCentral Ankrah NAD, Koster SE, Mantel-Teeuwisse KA, Arhinful KD, Agyepong AI, Lartey M. Facilitators and barriers to antiretroviral therapy adherence among adolescents in Ghana. Patient Prefer Adherence. 2016;10:329–37.CrossRefPubMedPubMedCentral
18.
go back to reference UNAIDS. Access to antiretroviral therapy in Africa: Status report on progress towards the 2015 targets. 2015. UNAIDS. Access to antiretroviral therapy in Africa: Status report on progress towards the 2015 targets. 2015.
19.
go back to reference Hass AD. Adherence to antiretroviral therapy during and after pregnancy: cohort study on women receiving care in Malawi’s option B + program. Clin Infect Dis. 2016;63:1227–35. Hass AD. Adherence to antiretroviral therapy during and after pregnancy: cohort study on women receiving care in Malawi’s option B + program. Clin Infect Dis. 2016;63:1227–35.
20.
go back to reference Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM. Adherence to antiretroviral therapy and viologic failure: a meta-analysis. Medicine (Baltimore). 2016; 95(3361). Bezabhe WM, Chalmers L, Bereznicki LR, Peterson GM. Adherence to antiretroviral therapy and viologic failure: a meta-analysis. Medicine (Baltimore). 2016; 95(3361).
24.
go back to reference Reda & Biadgilign, 2012 Reda AA, Biadgilign S. Determinants of adherence to antiretroviral therapy among HIV-infected patients in Africa. AIDS Res Treat 2012: 574656. Reda & Biadgilign, 2012 Reda AA, Biadgilign S. Determinants of adherence to antiretroviral therapy among HIV-infected patients in Africa. AIDS Res Treat 2012: 574656.
25.
go back to reference Yu Y, Dan L, Xi C, Zhulin H, Min W, Shuiyuan X. Medication adherence to ART among newly treated people living with HIV. BMC Public Health. 2018;18:825.CrossRefPubMedPubMedCentral Yu Y, Dan L, Xi C, Zhulin H, Min W, Shuiyuan X. Medication adherence to ART among newly treated people living with HIV. BMC Public Health. 2018;18:825.CrossRefPubMedPubMedCentral
26.
27.
go back to reference Chukwuma Anyaike OA, Atoyebi OI, Musa OA, Bolarinwa KA, Durowade A, Ogundiran. Oluwole Adeyemi Babatunde (2019). Adherence to combined Antiretroviral therapy (cART) among people living with HIV/AIDS in a Tertiary Hospital in Ilorin, Nigeria. Pan African Medical Journal. 2019;32:10. https://doi.org/10.11604/pamj.2019.32.10.7508. Chukwuma Anyaike OA, Atoyebi OI, Musa OA, Bolarinwa KA, Durowade A, Ogundiran. Oluwole Adeyemi Babatunde (2019). Adherence to combined Antiretroviral therapy (cART) among people living with HIV/AIDS in a Tertiary Hospital in Ilorin, Nigeria. Pan African Medical Journal. 2019;32:10. https://​doi.​org/​10.​11604/​pamj.​2019.​32.​10.​7508.
28.
go back to reference Obirikorang C, Sellah PK, Abledu JK, Fofie CO. Predictors of adherence to antiretroviral therapy among HIV/AIDS patients in the upper west region of Ghana. ISRN AIDS. 2013. Obirikorang C, Sellah PK, Abledu JK, Fofie CO. Predictors of adherence to antiretroviral therapy among HIV/AIDS patients in the upper west region of Ghana. ISRN AIDS. 2013.
29.
go back to reference Okotah AN, Korbuvi J. Adherence to antiretroviral therapy among adult HIV positive patients in Volta Regional Hospital, Ghana. Value Health. 2014;17:A329.CrossRefPubMed Okotah AN, Korbuvi J. Adherence to antiretroviral therapy among adult HIV positive patients in Volta Regional Hospital, Ghana. Value Health. 2014;17:A329.CrossRefPubMed
30.
go back to reference Baah-Danso M. Factors influencing adherence to antiretroviral therapy among people living with HIV and AIDS in Koforidua Regional Hospital. University of Ghana; 2017. Baah-Danso M. Factors influencing adherence to antiretroviral therapy among people living with HIV and AIDS in Koforidua Regional Hospital. University of Ghana; 2017.
31.
go back to reference Prah J, Anna H, Mohammed A, Obed L, Yvonne N. & Dorcas O. Y. Factors affecting adherence to ART among HIV/AIDS patients in Cape Coast metropolis, Ghana. Journal of HIV/AIDS. 2018;4(1). Prah J, Anna H, Mohammed A, Obed L, Yvonne N. & Dorcas O. Y. Factors affecting adherence to ART among HIV/AIDS patients in Cape Coast metropolis, Ghana. Journal of HIV/AIDS. 2018;4(1).
33.
go back to reference Snedecor GW. W.G. Cochran Statistical methods. 8th ed. Ames: Iowa State University Press; 1989. Iowa. Snedecor GW. W.G. Cochran Statistical methods. 8th ed. Ames: Iowa State University Press; 1989. Iowa.
34.
go back to reference Al-Qazaz HK, Hassali MA, Shafie AA, Sulaiman SA, Sundram S, Morisky DE. The eight-item Morisky medication adherence scale MMAS: translation and validation of the Malaysian version. Diabetes Res Clin Pract. 2010;90:216–21.CrossRefPubMedPubMedCentral Al-Qazaz HK, Hassali MA, Shafie AA, Sulaiman SA, Sundram S, Morisky DE. The eight-item Morisky medication adherence scale MMAS: translation and validation of the Malaysian version. Diabetes Res Clin Pract. 2010;90:216–21.CrossRefPubMedPubMedCentral
35.
go back to reference Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10:348–54.CrossRef Morisky DE, Ang A, Krousel-Wood M, Ward HJ. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens. 2008;10:348–54.CrossRef
36.
go back to reference Sakthivel V, Krishnasamy V, Mehalingam V. Level of Medication Adherence and Its Associated Factors among Patients Receiving Antiretroviral Therapy at a Tertiary Care Hospital in South India. J Caring Sci. 2020 Jun 1;9(2):93–97. 10.34172/JCS.2020.014. PMID: 32626671; PMCID: PMC7322410. Sakthivel V, Krishnasamy V, Mehalingam V. Level of Medication Adherence and Its Associated Factors among Patients Receiving Antiretroviral Therapy at a Tertiary Care Hospital in South India. J Caring Sci. 2020 Jun 1;9(2):93–97. 10.34172/JCS.2020.014. PMID: 32626671; PMCID: PMC7322410.
37.
go back to reference World Health Organization. Consolidated guielines on the use of antiret- roviral drugs for treating and preventing HIV infection. Geneva: World Health Organization; 2016. World Health Organization. Consolidated guielines on the use of antiret- roviral drugs for treating and preventing HIV infection. Geneva: World Health Organization; 2016.
38.
go back to reference Fite RO. Association between adherence to antiretroviral therapy and place of residence among adult HIV infected patients in Ethiopia: A systematic review and meta-analysis. PLoS ONE. 2021;16(9):e0256948.CrossRefPubMedPubMedCentral Fite RO. Association between adherence to antiretroviral therapy and place of residence among adult HIV infected patients in Ethiopia: A systematic review and meta-analysis. PLoS ONE. 2021;16(9):e0256948.CrossRefPubMedPubMedCentral
39.
go back to reference Surbhi A. Kaklottar and Siddaram Sarate. Treatment adherence and factors influencing adherence to antiretroviral therapy: a systematic review and meta-analysis. Int J Curr Adv Res. 2018;7(8):15020–4. Surbhi A. Kaklottar and Siddaram Sarate. Treatment adherence and factors influencing adherence to antiretroviral therapy: a systematic review and meta-analysis. Int J Curr Adv Res. 2018;7(8):15020–4.
40.
go back to reference Heestermans T, Browne JL, Aitken SC, Vervoort SC, Klipstein-Grobusch K. Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: A systematic review. BMJ Global Health. 2016;1(4):e000125. Heestermans T, Browne JL, Aitken SC, Vervoort SC, Klipstein-Grobusch K. Determinants of adherence to antiretroviral therapy among HIV-positive adults in sub-Saharan Africa: A systematic review. BMJ Global Health. 2016;1(4):e000125.
42.
go back to reference Kahema SE, Mgabo MR, Emidi B, Sigalla GN, Kajeguka DC. Factors Influencing Adherence to Antiretroviral Therapy among HIV Infected Patients in Nyamagana-Mwanza, Northern Tanzania: A Cross Sectional Study. Int Arch Med Microbiol. 2018;1:002. Kahema SE, Mgabo MR, Emidi B, Sigalla GN, Kajeguka DC. Factors Influencing Adherence to Antiretroviral Therapy among HIV Infected Patients in Nyamagana-Mwanza, Northern Tanzania: A Cross Sectional Study. Int Arch Med Microbiol. 2018;1:002.
43.
Metadata
Title
Socio-demographic factors associated with medication adherence among People Living with HIV in the Kumasi Metropolis, Ghana
Authors
Collins Adu
Kofi Akohene Mensah
Bright Opoku Ahinkorah
Dorothy Osei
Andrews William Tetteh
Abdul-Aziz Seidu
Publication date
01-12-2022
Publisher
BioMed Central
Published in
AIDS Research and Therapy / Issue 1/2022
Electronic ISSN: 1742-6405
DOI
https://doi.org/10.1186/s12981-022-00474-z

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