Skip to main content
Top
Published in: Archives of Virology 4/2017

01-04-2017 | Brief Report

Clinical and subclinical bovine leukemia virus infection in a dairy cattle herd in Zambia

Authors: Girja S. Pandey, Edgar Simulundu, Danstan Mwiinga, Kenny L. Samui, Aaron S. Mweene, Masahiro Kajihara, Alfred Mangani, Racheal Mwenda, Joseph Ndebe, Satoru Konnai, Ayato Takada

Published in: Archives of Virology | Issue 4/2017

Login to get access

Abstract

Bovine leukemia virus (BLV) causes enzootic bovine leucosis (EBL) and is responsible for substantial economic losses in cattle globally. However, information in Africa on the disease is limited. Here, based on clinical, hematological, pathological and molecular analyses, two clinical cases of EBL were confirmed in a dairy cattle herd in Zambia. In contrast, proviral DNA was detected by PCR in five apparently healthy cows from the same herd, suggesting subclinical BLV infection. Phylogenetic analysis of the env gene showed that the identified BLV clustered with Eurasian genotype 4 strains. This is the first report of confirmed EBL in Zambia.
Appendix
Available only for authorised users
Literature
1.
go back to reference King AMQ, Adams J, Carstens EB, Lefkowitz EJ (2012) Virus taxonomy: classification and nomenclature of viruses: ninth report of the ICTV. Elsevier/Academic Press, Amsterdam, p 1344 King AMQ, Adams J, Carstens EB, Lefkowitz EJ (2012) Virus taxonomy: classification and nomenclature of viruses: ninth report of the ICTV. Elsevier/Academic Press, Amsterdam, p 1344
2.
go back to reference Aida Y, Murakami H, Takahashi M, Takeshima SN (2013) Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus. Front Microbiol 4:328CrossRefPubMedPubMedCentral Aida Y, Murakami H, Takahashi M, Takeshima SN (2013) Mechanisms of pathogenesis induced by bovine leukemia virus as a model for human T-cell leukemia virus. Front Microbiol 4:328CrossRefPubMedPubMedCentral
3.
go back to reference Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, Balon H, Bouzar AB, Defoiche J, Burny A, Reichert M, Kettmann R, Willems L (2007) Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology 4:18CrossRefPubMedPubMedCentral Gillet N, Florins A, Boxus M, Burteau C, Nigro A, Vandermeers F, Balon H, Bouzar AB, Defoiche J, Burny A, Reichert M, Kettmann R, Willems L (2007) Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human. Retrovirology 4:18CrossRefPubMedPubMedCentral
4.
5.
go back to reference Buehring GC, Shen HM, Jensen HM, Jin DL, Hudes M, Block G (2015) Exposure to bovine leukemia virus is associated with breast cancer: a case-control study. PLoS One 10(9):e0134304CrossRefPubMedPubMedCentral Buehring GC, Shen HM, Jensen HM, Jin DL, Hudes M, Block G (2015) Exposure to bovine leukemia virus is associated with breast cancer: a case-control study. PLoS One 10(9):e0134304CrossRefPubMedPubMedCentral
6.
go back to reference Burny A, Cleuter Y, Kettmann R, Mammerickx M, Marbaix G, Portetelle D, Van den Broeke A, Willems L, Thomas R (1987) Bovine leukaemia: facts and hypothesis derived from the study of an infectious cancer. Cancer Surv 6:139–159PubMed Burny A, Cleuter Y, Kettmann R, Mammerickx M, Marbaix G, Portetelle D, Van den Broeke A, Willems L, Thomas R (1987) Bovine leukaemia: facts and hypothesis derived from the study of an infectious cancer. Cancer Surv 6:139–159PubMed
7.
go back to reference Mirsky ML, Olmstead CA, Da Y, Lewin HA (1996) The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection. J Virol 70:2178–2183PubMedPubMedCentral Mirsky ML, Olmstead CA, Da Y, Lewin HA (1996) The prevalence of proviral bovine leukemia virus in peripheral blood mononuclear cells at two subclinical stages of infection. J Virol 70:2178–2183PubMedPubMedCentral
8.
go back to reference Ghysdael J, Bruck C, Kettmann R, Burny A (1984) Bovine Leukemia virus. Curr Top Microbiol Immunol 112:1–19PubMed Ghysdael J, Bruck C, Kettmann R, Burny A (1984) Bovine Leukemia virus. Curr Top Microbiol Immunol 112:1–19PubMed
9.
go back to reference Hopkins SG, DiGiacomo RF (1997) Natural transmission of bovine leukemia virus in dairy and beef cattle. Vet Clin N Am Food Anim Pract 13(1):107–128CrossRef Hopkins SG, DiGiacomo RF (1997) Natural transmission of bovine leukemia virus in dairy and beef cattle. Vet Clin N Am Food Anim Pract 13(1):107–128CrossRef
10.
go back to reference Buxton BA, Hinkle NC, Schultz RD (1985) Role of insects in the transmission of bovine leukosis virus: potential for transmission by stable flies, horn flies, and tabanids. Am J Vet Res 46(1):123–126PubMed Buxton BA, Hinkle NC, Schultz RD (1985) Role of insects in the transmission of bovine leukosis virus: potential for transmission by stable flies, horn flies, and tabanids. Am J Vet Res 46(1):123–126PubMed
11.
go back to reference Ott SL, Johnson R, Wells SJ (2003) Association between bovine leukosis virus seroprevalence and herd-level productivity on US dairy farms. Prev Vet Med 61:249–262CrossRefPubMed Ott SL, Johnson R, Wells SJ (2003) Association between bovine leukosis virus seroprevalence and herd-level productivity on US dairy farms. Prev Vet Med 61:249–262CrossRefPubMed
12.
go back to reference Nuotio L, Rusanen H, Sihvonen L, Neuvonen E (2003) Eradication of enzootic bovine leukosis from Finland. Prev Vet Med 59:43–49CrossRefPubMed Nuotio L, Rusanen H, Sihvonen L, Neuvonen E (2003) Eradication of enzootic bovine leukosis from Finland. Prev Vet Med 59:43–49CrossRefPubMed
13.
go back to reference Acaite J, Tamosiunas V, Lukauskas K, Milius J, Pieskus J (2007) The eradication experience of enzootic bovine leukosis from Lithuania. Prev Vet Med 82:83–89CrossRefPubMed Acaite J, Tamosiunas V, Lukauskas K, Milius J, Pieskus J (2007) The eradication experience of enzootic bovine leukosis from Lithuania. Prev Vet Med 82:83–89CrossRefPubMed
14.
go back to reference Mushi EZ, Wibberley G, Kupe DC (1990) Antibodies to enzootic bovine viral leukosis in Botswana. Trop Anim Health Prod 22(2):126CrossRefPubMed Mushi EZ, Wibberley G, Kupe DC (1990) Antibodies to enzootic bovine viral leukosis in Botswana. Trop Anim Health Prod 22(2):126CrossRefPubMed
15.
go back to reference Zaghawa A, Beier D, Abd El-Rahim IH, Karim I, El-ballal S, Conraths FJ, Marquardt O (2002) An outbreak of enzootic bovine leukosis in upper Egypt: clinical, laboratory and molecular-epidemiological studies. J Vet Med B Infect Dis Vet Public Health 49(3):123–129CrossRefPubMed Zaghawa A, Beier D, Abd El-Rahim IH, Karim I, El-ballal S, Conraths FJ, Marquardt O (2002) An outbreak of enzootic bovine leukosis in upper Egypt: clinical, laboratory and molecular-epidemiological studies. J Vet Med B Infect Dis Vet Public Health 49(3):123–129CrossRefPubMed
16.
go back to reference Walrand F, Fumoux F, Roelants G, Parodi AL, Levy D (1986) Incidence of bovine leukemia virus specific antibodies in West African cattle. Int J Cancer 37(4):619–621CrossRefPubMed Walrand F, Fumoux F, Roelants G, Parodi AL, Levy D (1986) Incidence of bovine leukemia virus specific antibodies in West African cattle. Int J Cancer 37(4):619–621CrossRefPubMed
17.
go back to reference Ndou RV, Sejesho F, Dzoma BM, Motsei LE, Nyirenda M, Bakunzi FR (2011) A serosurvey of the prevalence of enzootic bovine leukosis in the Mafikeng area of the North West Province of South Africa. J Hum Ecol 36(1):53–55 Ndou RV, Sejesho F, Dzoma BM, Motsei LE, Nyirenda M, Bakunzi FR (2011) A serosurvey of the prevalence of enzootic bovine leukosis in the Mafikeng area of the North West Province of South Africa. J Hum Ecol 36(1):53–55
18.
go back to reference Morris SD, Myburgh JG, Van Vuuren M, Van der Vyver F (1996) Serological survey to determine the prevalence of bovine leukaemia virus antibodies in dairy cattle on selected farms in the Gauteng and Mpumalanga provinces. J S Afr Vet Assoc 67(3):146–147PubMed Morris SD, Myburgh JG, Van Vuuren M, Van der Vyver F (1996) Serological survey to determine the prevalence of bovine leukaemia virus antibodies in dairy cattle on selected farms in the Gauteng and Mpumalanga provinces. J S Afr Vet Assoc 67(3):146–147PubMed
19.
go back to reference Meas S, Nakayama M, Usui T, Nakazato Y, Yasuda J, Ohashi K, Onuma M (2004) Evidence for bovine immunodeficiency virus infection in cattle in Zambia. Jpn J Vet Res 52(1):3–8PubMed Meas S, Nakayama M, Usui T, Nakazato Y, Yasuda J, Ohashi K, Onuma M (2004) Evidence for bovine immunodeficiency virus infection in cattle in Zambia. Jpn J Vet Res 52(1):3–8PubMed
20.
go back to reference Pandey GS, Sharma RN, Chizyuka HGB (1986) Study of bovine neoplasms in Zambia. Bull Anim Health Prod Afr 32:289–291 Pandey GS, Sharma RN, Chizyuka HGB (1986) Study of bovine neoplasms in Zambia. Bull Anim Health Prod Afr 32:289–291
21.
go back to reference Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra DV, Panei CJ, González ET, Kanemaki M, Onuma M, Giovambattista G, Aida Y (2016) A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis. Retrovirology 13(1):4CrossRefPubMedPubMedCentral Polat M, Takeshima SN, Hosomichi K, Kim J, Miyasaka T, Yamada K, Arainga M, Murakami T, Matsumoto Y, de la Barra DV, Panei CJ, González ET, Kanemaki M, Onuma M, Giovambattista G, Aida Y (2016) A new genotype of bovine leukemia virus in South America identified by NGS-based whole genome sequencing and molecular evolutionary genetic analysis. Retrovirology 13(1):4CrossRefPubMedPubMedCentral
22.
go back to reference Lee E, Kim EJ, Ratthanophart J, Vitoonpong R, Kim BH, Cho IS, Song JY, Lee KK, Shin YK (2016) Molecular epidemiological and serological studies of bovine leukemia virus (BLV) infection in Thailand cattle. Infect Genet Evol 41:245–254CrossRefPubMed Lee E, Kim EJ, Ratthanophart J, Vitoonpong R, Kim BH, Cho IS, Song JY, Lee KK, Shin YK (2016) Molecular epidemiological and serological studies of bovine leukemia virus (BLV) infection in Thailand cattle. Infect Genet Evol 41:245–254CrossRefPubMed
23.
go back to reference Rola-Luszczak M, Pluta A, Olech M, Donnik I, Petropavlovskiy M, Gerilovych A, Vinogradova I, Choudhury B, Kuzmak J (2013) The molecular characterization of bovine leukaemia virus isolates from Eastern Europe and Siberia and its impact on phylogeny. PLoS One 8(3):e58705CrossRefPubMedPubMedCentral Rola-Luszczak M, Pluta A, Olech M, Donnik I, Petropavlovskiy M, Gerilovych A, Vinogradova I, Choudhury B, Kuzmak J (2013) The molecular characterization of bovine leukaemia virus isolates from Eastern Europe and Siberia and its impact on phylogeny. PLoS One 8(3):e58705CrossRefPubMedPubMedCentral
24.
go back to reference Fechner H, Blankenstein P, Looman AC, Elwert J, Geue L, Albrecht C, Kurg A, Beier D, Marquardt O, Ebner D (1997) Provirus variants of the bovine leukemia virus and their relation to the serological status of naturally infected cattle. Virology 237:261–269CrossRefPubMed Fechner H, Blankenstein P, Looman AC, Elwert J, Geue L, Albrecht C, Kurg A, Beier D, Marquardt O, Ebner D (1997) Provirus variants of the bovine leukemia virus and their relation to the serological status of naturally infected cattle. Virology 237:261–269CrossRefPubMed
25.
go back to reference Ndashe K, Simulundu E, Hang’ombe BM, Moonga L, Ogawa H, Takada A, Mweene AS (2016) Molecular characterization of infectious bursal disease viruses detected in vaccinated commercial broiler flocks in Lusaka, Zambia. Arch Virol 161(3):513–519CrossRefPubMed Ndashe K, Simulundu E, Hang’ombe BM, Moonga L, Ogawa H, Takada A, Mweene AS (2016) Molecular characterization of infectious bursal disease viruses detected in vaccinated commercial broiler flocks in Lusaka, Zambia. Arch Virol 161(3):513–519CrossRefPubMed
27.
go back to reference Thompson KG, Johnstone AC, Hilbink F (1993) Enzootic bovine leukosis in New Zealand—a case report and update. N Z Vet J 41(4):190–194CrossRefPubMed Thompson KG, Johnstone AC, Hilbink F (1993) Enzootic bovine leukosis in New Zealand—a case report and update. N Z Vet J 41(4):190–194CrossRefPubMed
28.
go back to reference Khudhair YI, Hasso SA, Yaseen NY, Al-Shammari AM (2016) Serological and molecular detection of bovine leukemia virus in cattle in Iraq. Emerg Microbes Infect 5:e56CrossRefPubMedPubMedCentral Khudhair YI, Hasso SA, Yaseen NY, Al-Shammari AM (2016) Serological and molecular detection of bovine leukemia virus in cattle in Iraq. Emerg Microbes Infect 5:e56CrossRefPubMedPubMedCentral
30.
go back to reference Merlini R, Gutiérrez G, Alvarez I, Jaworski JP, Carignano H, Poli M, Willems L, Trono K (2016) Bovine leukemia virus becomes established in dairy herds before the first lactation. Arch Virol 161(11):3215–3217CrossRefPubMed Merlini R, Gutiérrez G, Alvarez I, Jaworski JP, Carignano H, Poli M, Willems L, Trono K (2016) Bovine leukemia virus becomes established in dairy herds before the first lactation. Arch Virol 161(11):3215–3217CrossRefPubMed
31.
go back to reference Johnston ER, Albritton LM, Radke K (2002) Envelope proteins containing single amino acid substitutions support a structural model of the receptor binding domain of bovine leukemia virus surface protein. J Virol 76:10861–10872CrossRefPubMedPubMedCentral Johnston ER, Albritton LM, Radke K (2002) Envelope proteins containing single amino acid substitutions support a structural model of the receptor binding domain of bovine leukemia virus surface protein. J Virol 76:10861–10872CrossRefPubMedPubMedCentral
Metadata
Title
Clinical and subclinical bovine leukemia virus infection in a dairy cattle herd in Zambia
Authors
Girja S. Pandey
Edgar Simulundu
Danstan Mwiinga
Kenny L. Samui
Aaron S. Mweene
Masahiro Kajihara
Alfred Mangani
Racheal Mwenda
Joseph Ndebe
Satoru Konnai
Ayato Takada
Publication date
01-04-2017
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 4/2017
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-016-3205-0

Other articles of this Issue 4/2017

Archives of Virology 4/2017 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.