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Radiation Oncology

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Open Access 01-12-2012 | Research

High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy

Authors: Ingeborg Fraunholz, Claus Rödel, Luitpold Distel, Marget Rave-Fränk, Daniela Kohler, Stefan Falk, Franz Rödel

Published in: Radiation Oncology | Issue 1/2012

Abstract

Purpose

To investigate the prognostic value of survivin expression in pretreatment specimens from patients with anal cancer treated with concurrent 5-FU and mitomycin C-based chemoradiation (CRT).

Material and methods

Immunohistochemical staining for survivin was performed in pretreatment biopsies of 62 patients with anal carcinoma. Survivin expression was correlated with clinical and histopathological characteristics as well as local failure free- (LFFS), distant metastases free- (DMFS), cancer specific- (CSS), and overall survival (OS).

Results

Survivin staining intensity was weak in 10%, intermediate in 48% and intense in 42% of the patients. No association between survivin expression and clinicopathologic factors (tumor stage, age and HIV status) could be shown. In univariate analysis, the level of survivin staining was significantly correlated with DMFS (low survivin vs. high survivin: 94% vs. 74%, p = 0.04). T-stage, N-stage and the tumor grading were significantly associated with OS and CSS and with DMFS and LFFS, respectively. In multivariate analysis, survivin was confirmed as independent prognostic parameter for DMFS (RR, 0.04; p = 0.02) and for OS (RR, 0.27; p = 0.04).

Conclusion

Our results demonstrated that the level of pretreatment survivin is correlated with the clinical outcome in patients with anal carcinoma treated with concurrent CRT. Further studies are warranted to elucidate the complex role of survivin for the oncologic treatment and to exploit the protein as a therapeutic target in combined modality treatment of anal cancer.

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Title: High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy
Authors: Ingeborg Fraunholz
Claus Rödel
Luitpold Distel
Marget Rave-Fränk
Daniela Kohler
Stefan Falk
Franz Rödel
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2012
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-7-88

Keynote webinar | Spotlight on medication adherence

Springer Medicine

High survivin expression as a risk factor in patients with anal carcinoma treated with concurrent chemoradiotherapy

Abstract

Purpose

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Material and methods

Results

Conclusion

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