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Radiation Oncology
Published in: Radiation Oncology 1/2012

Open Access 01-12-2012 | Research

Preoperative rectal cancer staging with phased-array MR

Authors: Sabina Giusti, Piero Buccianti, Maura Castagna, Elena Fruzzetti, Silvia Fattori, Elisa Castelluccio, Davide Caramella, Carlo Bartolozzi

Published in: Radiation Oncology | Issue 1/2012

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Abstract

Background

We retrospectively reviewed magnetic resonance (MR) images of 96 patients with diagnosis of rectal cancer to evaluate tumour stage (T stage), involvement of mesorectal fascia (MRF), and nodal metastasis (N stage).
Our gold standard was histopathology.

Methods

All studies were performed with 1.5-T MR system (Symphony; Siemens Medical System, Erlangen, Germany) by using a phased-array coil. Our population was subdivided into two groups: the first one, formed by patients at T1-T2-T3, N0, M0 stage, whose underwent MR before surgery; the second group included patients at Tx N1 M0 and T3-T4 Nx M0 stage, whose underwent preoperative MR before neoadjuvant chemoradiation therapy and again 4-6 wks after the end of the treatment for the re-staging of disease.
Our gold standard was histopathology.

Results

MR showed 81% overall agreement with histological findings for T and N stage prediction; for T stage, this rate increased up to 95% for pts of group I (48/96), while for group II (48/96) it decreased to 75%.
Preoperative MR prediction of histologically involved MRF resulted very accurate (sensitivity 100%; specificity 100%) also after chemoradiation (sensitivity 100%; specificity 67%).

Conclusions

Phased-array MRI was able to clearly estimate the entire mesorectal fat and surrounding pelvic structures resulting the ideal technique for local preoperative rectal cancer staging.
Appendix
Available only for authorised users
Literature
1.
Maier A, Fuchsjager M: Peroperative staging of rectal cancer. Eur J Radiol 2003, 47: 89-97. 10.1016/S0720-048X(03)00161-XCrossRefPubMed
2.
Tang R, Wang JY, Chen JS: Survival impact of lymph node metastasis in TNM stage III carcinoma of the colon and rectum. J Am Coll Surg 1995, 180: 705-712.PubMed
3.
Willett CG, Badizadegan K, Ancukiewicz M, Shellito PC: Prognostic factors in stage T3N0 rectal cancer: do all patients require postoperative pelvic irradiation and chemotherapy? Dis Colon Rectum 1999, 42: 167-173. 10.1007/BF02237122CrossRefPubMed
4.
Kapiteijn E, Marijnen CA, Nagtegaal ID: Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001, 345: 638-646. 10.1056/NEJMoa010580CrossRefPubMed
5.
MacFarlane JK, Ryall RD, Heald RJ: Mesorectal excision for rectal cancer. Lancet 1993, 341: 457-460. 10.1016/0140-6736(93)90207-WCrossRefPubMed
6.
Beets-Tan RG, Beets GL: Rectal cancer: review with emphasis on MR imaging. Radiology 2004, 232: 773-783. 10.1148/radiol.2323031368CrossRef
7.
Bouzourene H, Bosman FT, Seelentag W: Importance of tumour regression assessment in predicting outcome in patients with locally advanced rectal carcinoma who are treated with pre-operative radiotherapy. Cancer 2002, 94: 1121-1130. 10.1002/cncr.10327CrossRefPubMed
8.
Heald RJ, Karanjia ND: Results of radical surgery for rectal cancer. World J Surg 1992,16(5):848-857. 10.1007/BF02066981CrossRefPubMed
9.
McArdle CS, Hole D: Imapct of variability among surgeons pn post-operative morbidity and mortality and ultimate survival. Br Med J 1991, 302: 1501-1505. 10.1136/bmj.302.6791.1501CrossRef
10.
MacFarlane JK, Ryall RD, Heald RJ: Mesorectal excision for rectal cancer. Lancet 1993,341(8843):457-460. 10.1016/0140-6736(93)90207-WCrossRefPubMed
11.
Hermanek P, Wiebelt H, Staimmer D, Riedl S: Prognostic factors of rectum carcinoma-experience of the german Multicentre Study SGCRC. German Study Group Colo-Rectal carcinoma. Tumori 1995,81(3 Suppl):60-64.
12.
Blomqvist L, Machado M, Rubio C: Rectal tumor staging: MR imaging using pelvic phased-array and endorectal coils vs endoscopic ultrasonography. Eur Radiol 2000, 10: 653-660. 10.1007/s003300050979CrossRefPubMed
13.
Beets-Tan RG, Beets GL, Vliegen RF: Accuracy of magnetic resonance imaging in prediction of tumor-free resection margin in rectal cancer surgery. Lancet 2001, 357: 497-504. 10.1016/S0140-6736(00)04040-XCrossRefPubMed
14.
Blomqvist L, Holm T, Rubio C, Hindmarsh T: Rectal tumors: MR imaging with endorectal and/or phased-array coils, and histopathological staging on giant sections-a comparative study. Acta Radiol 1997, 38: 437-444.PubMed
15.
Gagliardi G, Bayar S, Smith R, Salem RR: Preoperative staging of rectal cancer using magnetic resonance imaging with external phase-arrayed coils. Arch Surg 2002, 137: 447-451. 10.1001/archsurg.137.4.447CrossRefPubMed
16.
Brown G, Richards CJ, Newcombe RG: Rectal carcinoma: thin-section MR imaging for staging in 28 patients. Radiology 1999, 211: 215-222.CrossRefPubMed
17.
Vliegen RF, Beets GL, Beets-Tan RG: Mesorectal Fascia Invasion after Neoadjuvant Chemotherapy and Radiation Therapy for Locally Advanced Cancer: Accuracy of MR Imaging Prediction. Radiology 2008,246(2):454-462. 10.1148/radiol.2462070042CrossRefPubMed
18.
Goh V, Halligan S, Bartram CL: Local radiological staging of rectal cancer. Clin Radiol 2004, 59: 215-226. 10.1016/j.crad.2003.08.013CrossRefPubMed
19.
Kim JHC, Beets GL, Kim MJ, Kessels AG, Beets-Tan RG: High Resolution MR Imaging for nodal staging in rectal cancer: are there any criteria in addition to the size? Eur? Radiol 2004, 52: 78-83.
20.
Iafrate F, Laghi A, Paolantonio P, Passariello R: Preoperative Staging of Rectal Cancer with MR IMaging: Correlation with Surgical and Histopathologic Findings. Radiographics 2006, 26: 701-714. 10.1148/rg.263055086CrossRefPubMed
21.
Brown G, Richards CJ, Bourne MW: Morphologic predictors of lymph node status in rectal cancer with use of high-spatial-resolution MR imaging with histopathologic comparison. Radiology 2003,227(2):371-377. 10.1148/radiol.2272011747CrossRefPubMed
22.
Monig SP, Baldus SE, Zirbes TK: Lymph node size and metastatic infiltration in colon cancer. Ann Surg Oncol 1999, 6: 579-581. 10.1007/s10434-999-0579-1CrossRefPubMed
23.
Bjelovic M, Kalezic V, Petrovic M: Correlation of macroscopic and histological characteristics in the regional lymph nodes of patients with rectal and sigmoidal adenocarcinoma. Hepatogastroenterology 1998, 45: 433-438.PubMed
24.
Okizuka H, Sugimura K, Yshida T: Preoperative local staging of rectal carcinoma with MR imaging and a rectal balloon. J Magn Reson Imaging 1993, 3: 329-335. 10.1002/jmri.1880030207CrossRefPubMed
25.
Rafaelsen SR, Kronborg O, Fenger C: Digital rectal examination transrectal ultrasonography in staging of rectal cancer: a prospective, blind study. Acta Radiol 1994, 35: 300-304.PubMed
Metadata
Title
Preoperative rectal cancer staging with phased-array MR
Authors
Sabina Giusti
Piero Buccianti
Maura Castagna
Elena Fruzzetti
Silvia Fattori
Elisa Castelluccio
Davide Caramella
Carlo Bartolozzi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Radiation Oncology / Issue 1/2012
Electronic ISSN: 1748-717X
DOI
https://doi.org/10.1186/1748-717X-7-29

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