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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Herpes Virus | Research

Vitamin D serum level in participants with positive history of recurrent herpes labialis

Authors: Zahra Ranjbar, Fatemeh Lavaee, Maryam Karandish, Farnaz Peiravian, Fateme Zarei

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Aim

Vitamin D plays an important role in immune system regulation, also its deficiency is assumed to affect the patients’ predisposition to viral diseases such as recurrent herpes labialis. In this cross-sectional study, we tried to compare the mean serum level of vitamin D in participants with a positive history of recurrent herpes labial lesions and healthy controls.

Materials and methods

The vitamin D serum level of 43 participants with a positive history of recurrent herpes labial lesions who were referred to the Motahhari laboratory in Shiraz during 2020–2022, was compared with 42 healthy controls. It was assessed by an Elisa kit. An Independent T-test was used to compare the vitamin D serum level between two genders. In order to assess the mean age value and gender distribution, an independent T-test and Pearson Chi-Square were used, respectively for the two groups. The serum vitamin D level was compared between both control and test groups.

Results

There was no significant difference between vitamin D mean serum levels in the two evaluated groups (p.value = 0.72). Although the age (p.value = 0.09) and recurrence (p.value = 0.13) of herpes labialis had no statistically significant relation to the vitamin D serum level, the healing duration of herpes labialis was inversely related (p.value = 0.01). Lower-level of serum vitamin D were accompanied by a longer healing duration of the lesions.

Conclusion

Although the vitamin D serum level of participants with a history of recurrent herpes labialis had no relation with age and herpes virus recurrence frequency, a longer healing duration of lesions had been reported in patients with lower serum levels of vitamin D.
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Metadata
Title
Vitamin D serum level in participants with positive history of recurrent herpes labialis
Authors
Zahra Ranjbar
Fatemeh Lavaee
Maryam Karandish
Farnaz Peiravian
Fateme Zarei
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Herpes Virus
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-02924-0

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