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BMC Neurology
Published in: BMC Neurology 1/2022

Open Access 01-12-2022 | Herpes Virus | Case report

Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report

Authors: Klaus Berek, Ronny Beer, Astrid Grams, Raimund Helbok, Anna Lindner, Bettina Pfausler, Alois Schiefecker, Florian Deisenhammer, Harald Hegen

Published in: BMC Neurology | Issue 1/2022

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Abstract

Background

Post herpes simplex virus (HSV) autoimmune encephalitis has been reported mainly in association with NMDA receptor antibodies, however, never with Caspr2 antibodies.

Case presentation

We report an 82-year old female patient with encephalitis who presented with aphasia, left temporo-mesial hyperintense lesion on MRI, epileptiform discharges on spot electroencephalography, cerebrospinal fluid (CSF) lymphocytic pleocytosis and who showed positive HSV polymerase chain reaction in CSF as well as antibodies against contactin-associated protein-like 2 (Caspr2).

Conclusion

This is the first report of a patient with encephalitis who tested positive for HSV as well as for Caspr2 antibodies.
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Metadata
Title
Caspr2 antibodies in herpes simplex encephalitis: an extension of the spectrum of virus induced autoimmunity? – A case report
Authors
Klaus Berek
Ronny Beer
Astrid Grams
Raimund Helbok
Anna Lindner
Bettina Pfausler
Alois Schiefecker
Florian Deisenhammer
Harald Hegen
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-022-02637-x

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