Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Medical Oncology
Published in: Medical Oncology 11/2023

Open Access 01-11-2023 | Hepatocellular Carcinoma | Review Article

Roles of circRNAs in regulating the tumor microenvironment

Authors: Tao Liu, Kaijun Long, Zhengfeng Zhu, Yongxiang Song, Cheng Chen, Gang Xu, Xixian Ke

Published in: Medical Oncology | Issue 11/2023

Login to get access

Abstract

CircRNAs, a type of non-coding RNA widely present in eukaryotic cells, have emerged as a prominent focus in tumor research. However, the functions of most circRNAs remain largely unexplored. Known circRNAs exert their regulatory roles through various mechanisms, including acting as microRNA sponges, binding to RNA-binding proteins, and functioning as transcription factors to modulate protein translation and coding. Tumor growth is not solely driven by gene mutations but also influenced by diverse constituent cells and growth factors within the tumor microenvironment (TME). As crucial regulators within the TME, circRNAs are involved in governing tumor growth and metastasis. This review highlights the role of circRNAs in regulating angiogenesis, matrix remodeling, and immunosuppression within the TME. Additionally, we discuss current research on hypoxia-induced circRNAs production and commensal microorganisms’ impact on the TME to elucidate how circRNAs influence tumor growth while emphasizing the significance of modulating the TME.
Literature
1.
Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell. 2012;21(3):309–22.PubMedCrossRef
2.
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity’s roles in cancer suppression and promotion. Science. 2011;331(6024):1565–70.PubMedCrossRef
3.
4.
Paget S. The distribution of secondary growths in cancer of the breast. Cancer Metastasis Rev. 1989;8(2):98–101.PubMed
5.
6.
Hessmann E, Buchholz SM, Demir IE, et al. Microenvironmental determinants of pancreatic cancer. Physiol Rev. 2020;100(4):1707–51.PubMedCrossRef
7.
8.
Zhang HD, Jiang LH, Sun DW, et al. CircRNA: a novel type of biomarker for cancer. Breast Cancer. 2018;25(1):1–7.PubMedCrossRef
9.
Kristensen LS, Hansen TB, Veno MT, et al. Circular RNAs in cancer: opportunities and challenges in the field. Oncogene. 2018;37(5):555–65.PubMedCrossRef
10.
11.
Liu XQ, Gao YB, Zhao LZ, et al. Biogenesis, research methods, and functions of circular RNAs. Yi Chuan. 2019;41(6):469–85.PubMed
12.
13.
14.
Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–8.PubMedCrossRef
15.
Conn SJ, Pillman KA, Toubia J, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell. 2015;160(6):1125–34.PubMedCrossRef
16.
Aktas T, Avsar Ilik I, Maticzka D, et al. DHX9 suppresses RNA processing defects originating from the Alu invasion of the human genome. Nature. 2017;544(7648):115–9.PubMedCrossRef
17.
Zhang M, Huang N, Yang X, et al. A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene. 2018;37(13):1805–14.PubMedCrossRef
18.
Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 2018;110(3):304–15.PubMedCrossRef
19.
Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–64.PubMedCrossRef
20.
Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell. 2013;51(6):792–806.PubMedCrossRef
21.
Fasolo F, Di Gregoli K, Maegdefessel L, et al. Non-coding RNAs in cardiovascular cell biology and atherosclerosis. Cardiovasc Res. 2019;115(12):1732–56.PubMedPubMedCentralCrossRef
22.
Khan AQ, Ahmad F, Raza SS, et al. Role of non-coding RNAs in the progression and resistance of cutaneous malignancies and autoimmune diseases. Semin Cancer Biol. 2022;83:208–26.PubMedCrossRef
23.
Liang Q, Fu J, Wang X, et al. circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma. Allergy. 2023;78(6):1459–72.PubMedCrossRef
24.
Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 2011;17(11):1359–70.PubMedCrossRef
25.
Semenza GL. Cancer-stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis. Oncogene. 2013;32(35):4057–63.PubMedCrossRef
26.
Weis SM, Cheresh DA. Pathophysiological consequences of VEGF-induced vascular permeability. Nature. 2005;437(7058):497–504.PubMedCrossRef
27.
Zheng X, Ma YF, Zhang XR, et al. Circ_0056618 promoted cell proliferation, migration, and angiogenesis through sponging with miR-206 and upregulating CXCR4 and VEGF-A in colorectal cancer. Eur Rev Med Pharmacol Sci. 2020;24(8):4190–202.PubMed
28.
Jiang Y, Zhou J, Zhao J, et al. The U2AF2/circRNA ARF1/miR-342-3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells. J Exp Clin Cancer Res. 2020;39(1):182.PubMedPubMedCentralCrossRef
29.
Xie M, Yu T, Jing X, et al. Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. Mol Cancer. 2020;19(1):112.PubMedPubMedCentralCrossRef
30.
Guo Y, Guo Y, Chen C, et al. Circ3823 contributes to growth, metastasis, and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis. Mol Cancer. 2021;20(1):93.PubMedCentralCrossRef
31.
Xu Y, Leng K, Yao Y, et al. A circular RNA, Cholangiocarcinoma-Associated Circular RNA 1, contributes to cholangiocarcinoma progression, induces angiogenesis, and disrupts vascular endothelial barriers. Hepatology. 2021;73(4):1419–35.CrossRef
32.
Yu L, Zhu H, Wang Z, et al. Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling. Mol Cancer. 2022;21(1):167.PubMedPubMedCentralCrossRef
33.
Zeng Y, Fu BM. Resistance mechanisms of anti-angiogenic therapy and exosomes-mediated revascularization in Cancer. Front Cell Dev Biol. 2020;8:610661.PubMedCentralCrossRef
34.
Kuczynski EA, Reynolds AR. Vessel co-option and resistance to anti-angiogenic therapy. Angiogenesis. 2020;23(1):55–74.PubMedCrossRef
35.
Fathi Maroufi N, Taefehshokr S, Rashidi MR, et al. Vascular mimicry: changing the therapeutic paradigms in cancer. Mol Biol Rep. 2020;47(6):4749–65.PubMedCrossRef
36.
Shao Y, Lu B. The emerging roles of circular RNAs in vessel co-option and vasculogenic mimicry: clinical insights for anti-angiogenic therapy in cancers. Cancer Metastasis Rev. 2022;41(1):173–91.PubMedCrossRef
37.
Huang XY, Huang ZL, Huang J, et al. Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. J Exp Clin Cancer Res. 2020;39(1):20.PubMedPubMedCentralCrossRef
38.
Ma HB, Yao YN, Yu JJ, et al. Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506. Am J Transl Res. 2018;10(2):592–604.PubMedPubMedCentral
39.
Wang K, Sun Y, Tao W, et al. Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals. Cancer Lett. 2017;394:1–12.PubMedCrossRef
40.
41.
Mohan V, Das A, Sagi I. Emerging roles of ECM remodeling processes in cancer. Semin Cancer Biol. 2020;62:192–200.PubMedCrossRef
42.
Zhao B, Song X, Guan H. CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis. Life Sci. 2020;244:117179.PubMedCrossRef
43.
Huang P, Li M, Tang Q, et al. Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression. Apoptosis. 2022;27(9–10):751–61.PubMedCrossRef
44.
Zhang J, Peng Y, Jiang S, et al. Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis. J Clin Lab Anal. 2022;36(3):e24245.PubMedPubMedCentralCrossRef
45.
Luo G, Li R, Li Z. CircRNA circFNDC3B promotes esophageal cancer progression via cell proliferation, apoptosis, and migration regulation. Int J Clin Exp Pathol. 2018;11(8):4188–96.PubMedPubMedCentral
46.
Hong Y, Qin H, Li Y, et al. FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression. J Cell Physiol. 2019;234(11):19895–910.PubMedCentralCrossRef
47.
Pan Z, Cai J, Lin J, et al. A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating snail in colon cancer. Mol Cancer. 2020;19(1):71.PubMedCentralCrossRef
48.
Wang X, Tan M, Huang H, et al. Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278. J Clin Lab Anal. 2022;36(6):e24475.PubMedCentralCrossRef
49.
Du J, Zhang G, Qiu H, et al. The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway. Cell Mol Biol Lett. 2019;24:72.PubMedPubMedCentralCrossRef
50.
51.
52.
53.
Chen W, Yu X, Wang N, et al. Circ_RPPH1 regulates glioma cell malignancy by binding to miR-627-5p/miR-663a to induce SDC1 expression. Metab Brain Dis. 2022;37(4):1231–45.PubMedCrossRef
54.
Tang M, Wang F, Wang K, et al. Circ_0058063 promotes progression of thyroid cancer by sponging miR-330-3p/SDC4 axis. Anticancer Drugs. 2022;33(7):642–51.PubMedCrossRef
55.
Spinelli FM, Vitale DL, Sevic I, et al. Hyaluronan in the tumor microenvironment. Adv Exp Med Biol. 2020;1245:67–83.PubMedCrossRef
56.
Kim YH, Lee SB, Shim S, et al. Hyaluronic acid synthase 2 promotes malignant phenotypes of colorectal cancer cells through transforming growth factor beta signaling. Cancer Sci. 2019;110(7):2226–36.PubMedPubMedCentralCrossRef
57.
Karousou E, Misra S, Ghatak S, et al. Roles and targeting of the HAS/hyaluronan/CD44 molecular system in cancer. Matrix Biol. 2017;59:3–22.PubMedCrossRef
58.
Zhang W, Liu T, Li T, et al. Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis. Cancer Gene Ther. 2021;28(3–4):279–93.PubMedCrossRef
59.
Dai W, Zhai X, Chen Y, et al. CircMMP1 promotes colorectal cancer growth and metastasis by sponging miR-1238 and upregulating MMP family expression. Ann Transl Med. 2021;9(16):1341.PubMedPubMedCentralCrossRef
60.
Huang F, Jiang J, Yao Y, et al. Circular RNA Hsa_circRNA_101996 promotes the development of gastric Cancer via Upregulating Matrix Metalloproteinases-2/Matrix Metalloproteinases-9 through MicroRNA-143/Ten-eleven translocation-2 Pathway. J Cancer. 2021;12(22):6665–75.PubMedPubMedCentralCrossRef
61.
Sang M, Meng L, Liu S, et al. Circular RNA ciRS-7 maintains metastatic phenotypes as a ceRNA of miR-1299 to Target MMPs. Mol Cancer Res. 2018;16(11):1665–75.PubMedCrossRef
62.
Tsoumakidou M. The advent of immune stimulating CAFs in cancer. Nat Rev Cancer. 2023;23(4):258–69.PubMedCrossRef
63.
Mao X, Xu J, Wang W, et al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 2021;20(1):131.PubMedPubMedCentralCrossRef
64.
Geng X, Chen H, Zhao L, et al. Cancer-associated fibroblast (CAF) heterogeneity and targeting therapy of CAFs in pancreatic cancer. Front Cell Dev Biol. 2021;9:655152.PubMedPubMedCentralCrossRef
65.
Zheng S, Hu C, Lin H, et al. circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-kappaB signaling pathway. J Exp Clin Cancer Res. 2022;41(1):71.PubMedPubMedCentralCrossRef
66.
Liu G, Sun J, Yang Z-F, et al. Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis. Cell Death Dis. 2021;12(3):260.PubMedPubMedCentralCrossRef
67.
Zhou Y, Tang W, Zhuo H, et al. Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-kappaB) pathway. Bioengineered. 2022;13(3):4786–97.PubMedPubMedCentralCrossRef
68.
Hu C, Xia R, Zhang X, et al. circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis. Mol Cancer. 2022;21(1):1–21.CrossRef
69.
70.
71.
Riera-Domingo C, Audige A, Granja S, et al. Immunity, hypoxia, and metabolism-the menage a trois of cancer: implications for immunotherapy. Physiol Rev. 2020;100(1):1–102.PubMedCrossRef
72.
Vander Heiden MG, Cantley LC, Thompson CB. Understanding the warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–33.PubMedPubMedCentralCrossRef
73.
Li Q, Pan X, Zhu D, et al. Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR-338-3p/PKM2 axis under hypoxic stress. Hepatology. 2019;70(4):1298–316.PubMedCrossRef
74.
Jiang X, Guo S, Wang S, et al. EIF4A3-Induced circARHGAP29 promotes aerobic glycolysis in docetaxel-resistant prostate cancer through IGF2BP2/c-Myc/LDHA signaling. Cancer Res. 2022;82(5):831–45.PubMedCrossRef
75.
Lin J, Wang X, Zhai S, et al. Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1. J Hematol Oncol. 2022;15(1):128.PubMedPubMedCentralCrossRef
76.
77.
Tirpe AA, Gulei D, Ciortea SM, et al. Hypoxia: overview on hypoxia-mediated mechanisms with a focus on the role of HIF genes. Int J Mol Sci. 2019;20(24):6140.PubMedPubMedCentralCrossRef
78.
79.
Qian W, Huang T, Feng W, Circular. RNA HIPK3 promotes EMT of cervical cancer through sponging mir-338-3p to up-regulate HIF-1alpha. Cancer Manag Res. 2020;12:177–87.PubMedPubMedCentralCrossRef
80.
Chen LY, Wang L, Ren YX, et al. The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1alpha translation. Mol Cancer. 2020;19(1):164.PubMedPubMedCentralCrossRef
81.
Li H, Cao B, Zhao R, et al. circDNMT1 promotes malignant progression of gastric cancer through targeting miR-576-3p/Hypoxia inducible factor-1 alpha axis. Front Oncol. 2022;12:817192.PubMedPubMedCentralCrossRef
82.
Lu Q, Wang X, Zhu J, et al. Hypoxic tumor-derived exosomal Circ0048117 facilitates M2 macrophage polarization acting as miR-140 sponge in esophageal squamous cell carcinoma. Onco Targets Ther. 2020;13:11883–97.PubMedPubMedCentralCrossRef
83.
Chen ZQ, Zuo XL, Cai J, et al. Hypoxia-associated circPRDM4 promotes immune escape via HIF-1alpha regulation of PD-L1 in hepatocellular carcinoma. Exp Hematol Oncol. 2023;12(1):17.PubMedPubMedCentralCrossRef
84.
De Martel C, Ferlay J, Franceschi S, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13(6):607–15.PubMedCrossRef
85.
Guo R, Cui X, Li X, et al. CircMAN1A2 is upregulated by helicobacter pylori and promotes development of gastric cancer. Cell Death Dis. 2022;13(4):409.PubMedPubMedCentralCrossRef
86.
Zhang J, Bai J, Zhu H, et al. The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients. Sci Rep. 2022;12(1):6178.PubMedPubMedCentralCrossRef
87.
Du N, Li K, Wang Y, et al. CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis. Histol Histopathol. 2022;37(9):863–77.PubMed
88.
89.
Du Y, Zhang JY, Feng ZY, et al. Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1 alpha/VEGFA pathway. Cancer Lett. 2022;526:259–72.PubMedCrossRef
90.
Yao S, Jia X, Wang F, et al. CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3. PLoS Pathog. 2021;17(2):e1009294.PubMedPubMedCentralCrossRef
91.
Abere B, Zhou H, Li J, et al. Merkel cell polyomavirus encodes circular RNAs (circRNAs) enabling a dynamic circRNA/microRNA/mRNA regulatory network. mBio. 2020;11(6).CrossRef
92.
Park EM, Chelvanambi M, Bhutiani N, et al. Targeting the gut and tumor microbiota in cancer. Nat Med. 2022;28(4):690–703.PubMedCrossRef
93.
94.
Mittal D, Gubin MM, Schreiber RD, et al. New insights into cancer immunoediting and its three component phases–elimination, equilibrium and escape. Curr Opin Immunol. 2014;27:16–25.PubMedPubMedCentralCrossRef
95.
Gubin MM, Zhang X, Schuster H, et al. Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature. 2014;515(7528):577–81.PubMedPubMedCentralCrossRef
96.
Pitt JM, Vetizou M, Daillere R, et al. Resistance mechanisms to immune-checkpoint blockade in cancer: tumor-intrinsic and -extrinsic factors. Immunity. 2016;44(6):1255–69.PubMedCrossRef
97.
98.
99.
Biswas SK, Mantovani A. Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol. 2010;11(10):889–96.PubMedCrossRef
100.
Entezari M, Sadrkhanloo M, Rashidi M, et al. Non-coding RNAs and macrophage interaction in tumor progression. Crit Rev Oncol Hematol. 2022;173:103680.PubMedCrossRef
101.
Yang T, Wang R, Liu H, et al. Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in helicobacter pylori-induced chronic atrophic gastritis. Life Sci. 2021;266:118903.PubMedCrossRef
102.
103.
Zhao HY, Zhang YY, Xing T, et al. M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity. Signal Transduct Target Ther. 2021;6(1):234.PubMedPubMedCentralCrossRef
104.
Zhao SJ, Kong FQ, Jie J, et al. Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3beta/beta-catenin pathway. Theranostics. 2020;10(1):17–35.PubMedPubMedCentralCrossRef
105.
Wang F, Niu Y, Chen K, et al. Extracellular vesicle-packaged circATP2B4 mediates M2 macrophage polarization via miR-532-3p/SREBF1 Axis to promote epithelial ovarian cancer metastasis. Cancer Immunol Res. 2023;11(2):199–216.PubMedCrossRef
106.
Chen T, Liu Y, Li C, et al. Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis. Cancer Treat Res Commun. 2021;28:100412.PubMedCrossRef
107.
Lu C, Shi W, Hu W, et al. Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression. Pharmacol Res. 2022;177:106098.PubMedCrossRef
108.
Huang X, Wang J, Guan J, et al. Exosomal Circsafb2 reshaping tumor environment to promote renal cell carcinoma progression by mediating M2 macrophage polarization. Front Oncol. 2022;12:808888.PubMedPubMedCentralCrossRef
109.
110.
Vitale I, Manic G, Coussens LM, et al. Macrophages and metabolism in the tumor microenvironment. Cell Metab. 2019;30(1):36–50.PubMedCrossRef
111.
Zhang L, Zhang J, Li P, et al. Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3. Cell Death Dis. 2022;13(1):32.PubMedPubMedCentralCrossRef
112.
Ma J, Huang L, Gao YB, et al. M2 macrophage facilitated angiogenesis in cutaneous squamous cell carcinoma via circ_TNFRSF21/miR-3619-5p/ROCK axis. Kaohsiung J Med Sci. 2022;38(8):761–71.PubMedCrossRef
113.
Gu X, Shi Y, Dong M, et al. Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer. Cell Death Dis. 2021;12(9):818.PubMedPubMedCentralCrossRef
114.
Gao J, Ao YQ, Zhang LX, et al. Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1. J Exp Clin Cancer Res. 2022;41(1):295.PubMedPubMedCentralCrossRef
115.
Brown CC, Gottschalk RA. Volume control: turning the dial on regulatory T cells. Cell. 2021;184(15):3847–9.PubMedCrossRef
116.
Huang M, Huang X, Huang N. Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells. Cancer Sci. 2022;113(6):1968–83.PubMedPubMedCentralCrossRef
117.
Xu YJ, Zhao JM, Gao C, et al. Hsa_circ_0136666 activates treg-mediated immune escape of colorectal cancer via miR-497/PD-L1 pathway. Cell Signal. 2021;86:110095.PubMedCrossRef
118.
Chen SW, Zhu SQ, Pei X, et al. Cancer cell-derived exosomal circUSP7 induces CD8(+) T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC. Mol Cancer. 2021;20(1):144.PubMedPubMedCentralCrossRef
119.
Yang C, Wu S, Mou Z, et al. Exosome-derived circTRPS1 promotes malignant phenotype and CD8 + T cell exhaustion in bladder cancer microenvironments. Mol Ther. 2022;30(3):1054–70.PubMedPubMedCentralCrossRef
120.
Wang X, Ma R, Zhang X, et al. Crosstalk between N6-methyladenosine modification and circular RNAs: current understanding and future directions. Mol Cancer. 2021;20(1):121.PubMedPubMedCentralCrossRef
121.
Liu Z, Wang T, She Y, et al. N(6)-methyladenosine-modified circIGF2BP3 inhibits CD8(+) T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer. Mol Cancer. 2021;20(1):105.PubMedPubMedCentralCrossRef
122.
Song-Yang Wu TF. Natural killer cells in cancer biology and therapy. Mol Cancer. 2020;19:26.
123.
Cozar B, Greppi M, Carpentier S, et al. Tumor-infiltrating natural killer cells. Cancer Discov. 2021;11(1):34–44.PubMedCrossRef
124.
Yang F, Chen Y, Luo L, et al. circFOXO3 Induced by KLF16 modulates clear cell renal cell carcinoma growth and natural killer cell cytotoxic activity through sponging miR-29a-3p and miR-122-5p. Dis Markers. 2022;2022:6062236.PubMedPubMedCentralCrossRef
125.
Li S, Chen Z, Zhou R, et al. Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1[J]. Histol Histopathol. 2022;37(12):1185–99.PubMed
126.
Shi M, Li ZY, Zhang LM, et al. Hsa_circ_0007456 regulates the natural killer cell-mediated cytotoxicity toward hepatocellular carcinoma via the miR-6852-3p/ICAM-1 axis[J]. Cell Death Dis. 2021;12(1):94.PubMedPubMedCentralCrossRef
127.
Ke H, Zhang J, Wang F, et al. ZNF652-Induced circRHOT1 Promotes SMAD5 expression to modulate tumorigenic properties and nature killer cell-mediated toxicity in bladder cancer via targeting miR-3666. J Immunol Res. 2021;2021:7608178.PubMedPubMedCentralCrossRef
Metadata
Title
Roles of circRNAs in regulating the tumor microenvironment
Authors
Tao Liu
Kaijun Long
Zhengfeng Zhu
Yongxiang Song
Cheng Chen
Gang Xu
Xixian Ke
Publication date
01-11-2023
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2023
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-023-02194-4

Other articles of this Issue 11/2023

Medical Oncology 11/2023 Go to the issue

Review Article

How gallic acid regulates molecular signaling: role in cancer drug resistance

Review Article

Himalayan flora: targeting various molecular pathways in lung cancer

Review Article

Theranostic signature of tumor-derived exosomes in cancer

Original Paper

Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the AblT315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia

Original Paper

Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals

Review Article

Unveiling the genetic and epigenetic landscape of colorectal cancer: new insights into pathogenic pathways
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine
Image Credits