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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 3/2019

01-12-2019 | Hepatitis B | ASO Author Reflections

ASO Author Reflections: A New Look at the Clinical Significance of MVI in Hepatocellular Carcinoma

Authors: Derek J. Erstad, MD, Kenneth K. Tanabe, MD

Published in: Annals of Surgical Oncology | Special Issue 3/2019

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Excerpt

Recent evidence indicates that hepatocellular carcinoma (HCC) biology is an important determinant of prognosis, although we are only beginning to understand and incorporate tumor biology into clinical care. One aspect of HCC biology is microvascular invasion (MVI), which describes the histologic presence of malignant cells within adjacent microvessels and is thought to capture the process by which cancers metastasize to local and distant sites. In our literature review, we set out to understand the prognostic and therapeutic implications of MVI in HCC outcomes.1 We also reviewed the literature to summarize the current status of preoperative MVI detection by various radiographic and serologic modalities. …
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Ueno M, Hayami S, Shigekawa Y, Kawai M, Hirono S, Okada K, Tamai H, Shingaki N, Mori Y, Ichinose M, Yamaue H. Prognostic impact of surgery and radiofrequency ablation on single nodular HCC 5 cm: cohort study based on serum HCC markers. J Hepatol. 2015;63:1352–9.CrossRef
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Mazzaferro V, Llovet JM, Miceli R, Bhoori S, Schiavo M, Mariani L, Camerini T, Roayaie S, Schwartz ME, Grazi GL, Adam R, Neuhaus P, Salizzoni M, Bruix J, Forner A, De Carlis L, Cillo U, Burroughs AK, Troisi R, Rossi M, Gerunda GE, Lerut J, Belghiti J, Boin I, Gugenheim J, Rochling F, Van Hoek B, Majno P, Metroticket Investigator Study G. Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol. 2009;10:35–43.CrossRef
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Metadata
Title
ASO Author Reflections: A New Look at the Clinical Significance of MVI in Hepatocellular Carcinoma
Authors
Derek J. Erstad, MD
Kenneth K. Tanabe, MD
Publication date
01-12-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue Special Issue 3/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-019-07364-1

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