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Health and Quality of Life Outcomes

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Open Access 01-12-2019 | Hepatitis B | Research

Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction

Authors: Hong Wang, Ying Zhou, Rong Yan, Guo Qing Ru, Li Li Yu, Jiong Yao

Published in: Health and Quality of Life Outcomes | Issue 1/2019

Abstract

Background

Fatigue is an important clinical finding in patients with chronic hepatitis virus infection. However, studies assessing fatigue in patients with chronic hepatitis B (CHB) are very limited. This study aimed to quantify the severity of fatigue in patients with CHB, to determine whether perceived fatigue reflects impairment of functional ability, and to explore potential causes.

Methods

A total of 133 patients with histologically proven CHB and 59 community controls were assessed using the fatigue impact scale (FIS).

Results

The degree of fatigue was significantly higher in patients with CHB than in controls (mean (range) FIS 24.9 (0–91) vs. 15.7 (0–31), p < 0.001). Fatigue experienced by patients with CHB was similar to that in primary biliary cirrhosis (PBC) (n = 20) (FIS 22.2 vs. 20.9, p = 0.28). No association was found between FIS and biochemistry and histological parameters of liver disease severity. Significant associations were found between fatigue severity and cognitive impairment (r = 0.39, p < 0.001), daytime somnolence (r = 0.32, p < 0.001), scores of the Chronic Liver Disease Questionnaire (r = − 0.31, p < 0.001), and autonomic symptoms (r = 0.43, p < 0.001). The level of autonomic symptom was the only factor independently associated with the degree of fatigue.

Conclusion

Fatigue is a significant problem of functional ability impairment in CHB and similar in degree to that in PBC patients. Fatigue in patients with CHB appears to be unrelated to the severity of liver disease but is associated with significant autonomic symptoms.

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Title: Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction
Authors: Hong Wang
Ying Zhou
Rong Yan
Guo Qing Ru
Li Li Yu
Jiong Yao
Publication date: 01-12-2019
Publisher: BioMed Central
Keywords: Hepatitis B
Fatigue
Published in: Health and Quality of Life Outcomes / Issue 1/2019
Electronic ISSN: 1477-7525
DOI: https://doi.org/10.1186/s12955-019-1200-3

At a glance: The STEP trials

Springer Medicine

Fatigue in chronic hepatitis B patients is significant and associates with autonomic dysfunction

Abstract

Background

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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