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Current Hepatology Reports

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01-09-2020 | Hepatitis B | Hepatitis B (JK Lim, Section Editor)

Point of Care Diagnostic Testing for Hepatitis B Virus

Authors: Kathy Jackson, Robert G. Gish

Published in: Current Hepatology Reports | Issue 3/2020

Abstract

Purpose of Review

As we strive to reach the World Health Organization (WHO) goal of eliminating viral hepatitis as a public health threat by 2030, point of care tests (POCTs) will be important in low- to middle-income and developed countries. This review aims to investigate available POCT choices for hepatitis B virus (HBV) and to provide an algorithm for screening, assessing, and monitoring chronic HBV.

Recent Findings

There are 3 WHO pre-qualified rapid diagnostic assays for hepatitis B surface antigen (HBsAg) that are sensitive, specific, and reliable in screening for HBV: SD Bioline, Determine 2, and VIKIA. POCTs for other biomarkers are less reliable and sensitive but have some applicability. The Xpert® HBV Viral Load assay is sensitive and specific with a wide dynamic range.

Summary

While POCT for HBeAg and HBV antibodies require improvement, HBsAg POCT and the Xpert® HBV Viral Load assay are reliable and available now.

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Title: Point of Care Diagnostic Testing for Hepatitis B Virus
Authors: Kathy Jackson
Robert G. Gish
Publication date: 01-09-2020
Publisher: Springer US
Keywords: Hepatitis B
Care
Published in: Current Hepatology Reports / Issue 3/2020
Electronic ISSN: 2195-9595
DOI: https://doi.org/10.1007/s11901-020-00531-z

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Abstract

Purpose of Review

Recent Findings

Summary

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