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01-06-2022 | Hepatitis A | Original Article

Position statement of the Spanish Society of Pediatric Rheumatology on infection screening, prophylaxis, and vaccination of pediatric patients with rheumatic diseases and immunosuppressive therapies: Part 1 (screening)

Authors: Esmeralda Núñez Cuadros, Joan Calzada-Hernández, Daniel Clemente, Sara Guillén Martín, Laura Fernández Silveira, María José Lirola-Cruz, Alfredo Tagarro, Marisol Camacho Lovillo, Rosa María Alcobendas Rueda, Agustín López López, Miren Satrustegi Aritziturri, Cristina Calvo

Published in: European Journal of Pediatrics | Issue 6/2022

Abstract

This study provides practical recommendations on infection screening in pediatric patients with immune-mediated rheumatic diseases and immunosuppressive therapies. For this reason, a qualitative approach was applied. A narrative literature review was performed via Medline. Primary searches were conducted using Mesh and free texts to identify articles that analyzed data on infections and vaccinations in pediatric patients with immune-mediated rheumatic diseases and immunosuppressive therapies. The results were presented and discussed in a nominal group meeting, comprising a committee of 12 pediatric rheumatologists from the infections prevention and treatment working group of the Spanish Society of Pediatric Rheumatology. Several recommendations were generated. A consensus procedure was implemented via a Delphi process that was extended to members of the Spanish Society of Pediatric Rheumatology and Vaccine Advisory Committee of the Spanish Association of Pediatrics. Participants to the process produced a score ranging from 0 = totally disagree to 10 = totally agree. Agreement was considered if at least 70% of participants voted ≥ 7. The literature review included more than 400 articles. Overall, 63 recommendations were generated (21 on infection screening) voted by 59 pediatric rheumatologists and other pediatric specialists, all of them achieving the pre-established agreement level. The recommendations on screening cover all the procedures (serology, assessment of risk factors, and other clinical activities) connected with the screening for infections including tuberculosis; hepatitis A, B, and C viruses; measles; mumps; rubella; diphtheria; and other infections.

Conclusion: Screening for infections is an essential part of risk management in pediatric patients with immune-mediated rheumatic diseases and immunosuppressive therapies.

What is Known:

• Infectious diseases and related complications are a major cause of morbidity and mortality in patients with immune-mediated rheumatic diseases.

• At present, practical information on infectious prophylaxis in children with rheumatic diseases is limited, and often extrapolated from children with cancer.

What is New:

• In the absence of evidence, a literature review and a Delphi survey were conducted to establish a series of expert recommendations that would be useful in clinical practice, providing a practical and simple day-to-day approach to be used by pediatric rheumatologists.

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Title: Position statement of the Spanish Society of Pediatric Rheumatology on infection screening, prophylaxis, and vaccination of pediatric patients with rheumatic diseases and immunosuppressive therapies: Part 1 (screening)
Authors: Esmeralda Núñez Cuadros
Joan Calzada-Hernández
Daniel Clemente
Sara Guillén Martín
Laura Fernández Silveira
María José Lirola-Cruz
Alfredo Tagarro
Marisol Camacho Lovillo
Rosa María Alcobendas Rueda
Agustín López López
Miren Satrustegi Aritziturri
Cristina Calvo
Publication date: 01-06-2022
Publisher: Springer Berlin Heidelberg
Keywords: Hepatitis A
Mumps
Hepatitis B
Vaccination
Rubella
Pediatric Rheumatology
Published in: European Journal of Pediatrics / Issue 6/2022
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-022-04418-7

Keynote webinar | Spotlight on medication adherence

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Position statement of the Spanish Society of Pediatric Rheumatology on infection screening, prophylaxis, and vaccination of pediatric patients with rheumatic diseases and immunosuppressive therapies: Part 1 (screening)

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Keynote webinar | Spotlight on medication adherence

Springer Medicine

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