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Published in: Current Gastroenterology Reports 10/2023

21-08-2023 | Hepatic Encephalopathy

TIPS: indications, Contraindications, and Evaluation

Authors: Allison Carroll, Justin R. Boike

Published in: Current Gastroenterology Reports | Issue 10/2023

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Abstract

Purpose of Review

This review summarizes the current and emerging indications, contraindications, and evaluation for TIPS. In the last three decades of use, there have been substantial changes and progress in this field, including the use of controlled-expansion, covered stents, which has broadened the clinical uses of TIPS.

Recent Findings

Recent findings have rapidly expanded the indications for TIPS, including emerging uses in hepatorenal syndrome, hepatopulmonary syndrome and before abdominal surgery. The widespread use of controlled-expansion, covered stents has decreased rates of post-TIPS hepatic encephalopathy, opening TIPS to a larger patient population.

Summary

Overall, with newer stent technology and more research in this area, the clinical utility and potential of TIPS has rapidly expanded. Going forward, a renewed focus on randomized-control trials and long-term outcomes will be a crucial element to selecting appropriate TIPS recipients and recommending emerging indications for this procedure.
Literature
5.
go back to reference Boyer TD, Haskal ZJ. The role of Transjugular Intrahepatic Portosystemic Shunt (Tips) in the management of Portal Hypertension: Update 2009. Hepatology. 2010;51(1). Boyer TD, Haskal ZJ. The role of Transjugular Intrahepatic Portosystemic Shunt (Tips) in the management of Portal Hypertension: Update 2009. Hepatology. 2010;51(1).
14.
go back to reference ••Lv Y, Wang Z, Li K, Wang Q, Bai W, Yuan X et al. Risk Stratification Based on Chronic Liver Failure Consortium Acute Decompensation Score in Patients With Child-Pugh B Cirrhosis and Acute Variceal Bleeding. Hepatology. 2021;73(4):1478-93. doi: 10.1002/hep.31478. There has been a large volume of previous work establishing the uitlity of early TIPS in CP-C patients, and limited utility in CP-A patients. However, CP-B had been less clear. In this work, Lv suggest the utility of using CLIF-C AD scoring to stratify CP-B patients who will benefit most from early TIPS ••Lv Y, Wang Z, Li K, Wang Q, Bai W, Yuan X et al. Risk Stratification Based on Chronic Liver Failure Consortium Acute Decompensation Score in Patients With Child-Pugh B Cirrhosis and Acute Variceal Bleeding. Hepatology. 2021;73(4):1478-93. doi: 10.1002/hep.31478. There has been a large volume of previous work establishing the uitlity of early TIPS in CP-C patients, and limited utility in CP-A patients. However, CP-B had been less clear. In this work, Lv suggest the utility of using CLIF-C AD scoring to stratify CP-B patients who will benefit most from early TIPS
19.
21.
go back to reference Wang YB, Zhang JY, Gong JP, Zhang F, Zhao Y. Balloon-occluded retrograde transvenous obliteration versus transjugular intrahepatic portosystemic shunt for treatment of gastric varices due to portal hypertension: a meta-analysis. J Gastroenterol Hepatol (Australia). 2016;31(4):727–33. https://doi.org/10.1111/jgh.13248.CrossRef Wang YB, Zhang JY, Gong JP, Zhang F, Zhao Y. Balloon-occluded retrograde transvenous obliteration versus transjugular intrahepatic portosystemic shunt for treatment of gastric varices due to portal hypertension: a meta-analysis. J Gastroenterol Hepatol (Australia). 2016;31(4):727–33. https://​doi.​org/​10.​1111/​jgh.​13248.CrossRef
30.
go back to reference Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK et al. Diagnosis, evaluation, and management of Ascites, spontaneous bacterial peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the study of Liver Diseases. Hepatology. 2021;74(2). Biggins SW, Angeli P, Garcia-Tsao G, Ginès P, Ling SC, Nadim MK et al. Diagnosis, evaluation, and management of Ascites, spontaneous bacterial peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the study of Liver Diseases. Hepatology. 2021;74(2).
54.
go back to reference Chang J, Höfer P, Böhling N, Lingohr P, Manekeller S, Kalff JC, et al. Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score. JHEP Rep. 2022;4(3):100442. https://doi.org/10.1016/j.jhepr.2022.100442. This work explore the hypothesis that TIPS before abdominal surgery might reduce the risk of ACLF, a known complication of abdominal surgery in cirrhotic patients. Chang et al establish a CLIF-AD score>45 as a useful cuttoff for determining who might benefit most from TIPS before a viseral operation to reduce changes of post-operative ACLF.CrossRefPubMedPubMedCentral Chang J, Höfer P, Böhling N, Lingohr P, Manekeller S, Kalff JC, et al. Preoperative TIPS prevents the development of postoperative acute-on-chronic liver failure in patients with high CLIF-C AD score. JHEP Rep. 2022;4(3):100442. https://​doi.​org/​10.​1016/​j.​jhepr.​2022.​100442. This work explore the hypothesis that TIPS before abdominal surgery might reduce the risk of ACLF, a known complication of abdominal surgery in cirrhotic patients. Chang et al establish a CLIF-AD score>45 as a useful cuttoff for determining who might benefit most from TIPS before a viseral operation to reduce changes of post-operative ACLF.CrossRefPubMedPubMedCentral
55.
go back to reference Aryan M, McPhail J, Ravi S, Harris P, Allamneni C, Shoreibah M. Perioperative Transjugular Intrahepatic Portosystemic Shunt is Associated with decreased postoperative complications in decompensated cirrhotics undergoing abdominal surgery. Am Surg. 2022;88(7):1613–20. https://doi.org/10.1177/00031348211069784. In this retrospective obervational study, Aryan et al expand the potential benefits of pre-operative TIPS to include lower rates of post-operative ascites, AKI and infection comparted to patients who did not receive pre-operative TIPS.CrossRefPubMed Aryan M, McPhail J, Ravi S, Harris P, Allamneni C, Shoreibah M. Perioperative Transjugular Intrahepatic Portosystemic Shunt is Associated with decreased postoperative complications in decompensated cirrhotics undergoing abdominal surgery. Am Surg. 2022;88(7):1613–20. https://​doi.​org/​10.​1177/​0003134821106978​4. In this retrospective obervational study, Aryan et al expand the potential benefits of pre-operative TIPS to include lower rates of post-operative ascites, AKI and infection comparted to patients who did not receive pre-operative TIPS.CrossRefPubMed
56.
59.
go back to reference Wannhoff A, Hippchen T, Weiss CS, Friedrich K, Rupp C, Neumann-Haefelin C, et al. Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt. Aliment Pharmacol Ther. 2016;43(9):955–65. https://doi.org/10.1111/apt.13569.CrossRefPubMed Wannhoff A, Hippchen T, Weiss CS, Friedrich K, Rupp C, Neumann-Haefelin C, et al. Cardiac volume overload and pulmonary hypertension in long-term follow-up of patients with a transjugular intrahepatic portosystemic shunt. Aliment Pharmacol Ther. 2016;43(9):955–65. https://​doi.​org/​10.​1111/​apt.​13569.CrossRefPubMed
68.
go back to reference Nardelli S, Gioia S, Pasquale C, Pentassuglio I, Farcomeni A, Merli M, et al. Cognitive impairment predicts the occurrence of hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt. Official J Am Coll Gastroenterol | ACG. 2016;111(4):523–8. https://doi.org/10.1038/ajg.2016.29.CrossRef Nardelli S, Gioia S, Pasquale C, Pentassuglio I, Farcomeni A, Merli M, et al. Cognitive impairment predicts the occurrence of hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt. Official J Am Coll Gastroenterol | ACG. 2016;111(4):523–8. https://​doi.​org/​10.​1038/​ajg.​2016.​29.CrossRef
69.
go back to reference •• Saab S, Zhao M, Asokan I, Yum JJ, Lee EW. History of Hepatic Encephalopathy Is Not a Contraindication to Transjugular Intrahepatic Portosystemic Shunt Placement for Refractory Ascites. Clin Transl Gastroenterol. 2021;12(8):e00378. doi: 10.14309/ctg.0000000000000378. Refractory ascites is one of the most common indications for TIPS and HE is one of the most common compolications of the procedure. Given that many patients with PH have a history of HE, Saab suggest with this work that HE should not be a contraindication for TIPS as long as the HE is well controlled before TIPS procedure. •• Saab S, Zhao M, Asokan I, Yum JJ, Lee EW. History of Hepatic Encephalopathy Is Not a Contraindication to Transjugular Intrahepatic Portosystemic Shunt Placement for Refractory Ascites. Clin Transl Gastroenterol. 2021;12(8):e00378. doi: 10.14309/ctg.0000000000000378. Refractory ascites is one of the most common indications for TIPS and HE is one of the most common compolications of the procedure. Given that many patients with PH have a history of HE, Saab suggest with this work that HE should not be a contraindication for TIPS as long as the HE is well controlled before TIPS procedure.
71.
go back to reference • Lv Y, Chen H, Luo B, Bai W, Li K, Wang Z et al. Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial. Hepatology. 2022;76(3):676 – 88. doi: 10.1002/hep.32453. Lv present the first RCT demonstrating the efficacy of concurrent SPSS embolization with TIPS to reduce post-TIPS rates of HE by 62%. This suggests the utility of considering prophylactic large SPSS embolization for specific patients to reduce rates of post-TIPS HE • Lv Y, Chen H, Luo B, Bai W, Li K, Wang Z et al. Concurrent large spontaneous portosystemic shunt embolization for the prevention of overt hepatic encephalopathy after TIPS: A randomized controlled trial. Hepatology. 2022;76(3):676 – 88. doi: 10.1002/hep.32453. Lv present the first RCT demonstrating the efficacy of concurrent SPSS embolization with TIPS to reduce post-TIPS rates of HE by 62%. This suggests the utility of considering prophylactic large SPSS embolization for specific patients to reduce rates of post-TIPS HE
72.
go back to reference ••Knight GM, Clark J, Boike JR, Maddur H, Ganger DR, Talwar A, et al. 10.1002/hep.31915. Extra hepatic portal vein occlusion from portal vein thrombosis is a disease process with limited treatment options. Here, for the first time, TIPS has been shown as a feasible option for treatment of EHPVO in patients who failed first-line treatments. Hepatology. 2021;74(5):2735–44. TIPS for Adults Without Cirrhosis With Chronic Mesenteric Venous Thrombosis and EHPVO Refractory to Standard-of-Care Therapy. ••Knight GM, Clark J, Boike JR, Maddur H, Ganger DR, Talwar A, et al. 10.1002/hep.31915. Extra hepatic portal vein occlusion from portal vein thrombosis is a disease process with limited treatment options. Here, for the first time, TIPS has been shown as a feasible option for treatment of EHPVO in patients who failed first-line treatments. Hepatology. 2021;74(5):2735–44. TIPS for Adults Without Cirrhosis With Chronic Mesenteric Venous Thrombosis and EHPVO Refractory to Standard-of-Care Therapy.
Metadata
Title
TIPS: indications, Contraindications, and Evaluation
Authors
Allison Carroll
Justin R. Boike
Publication date
21-08-2023
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 10/2023
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-023-00884-7

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