Published in:
Open Access
01-10-2012 | Poster presentation
Hemozoin impairs cell cycle progression and promotes chemokine release in human microvascular endothelial cells
Authors:
Nicoletta Basilico, Daniela Girelli, Sarah D’Alessandro, Yolanda Corbett, Mauro Prato, Silvia Carluccio, Serena Del Bue, Pasquale Ferrante, Donatella Taramelli
Published in:
Malaria Journal
|
Special Issue 1/2012
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Excerpt
Cerebral malaria (CM) is a fatal complication of P.falciparum infection caused by the cytoadherence of infected erythrocytes to brain endothelial cells followed by micro-circulatory obstruction, blood-brain barrier (BBB) damage, ring hemorrhages, inflammatory response and neurological sequelae. The combination of both parasite and host factors are involved in the pathogenesis of CM. In particular, malarial pigment, hemozoin (HZ) was shown to interfere with monocytes and endothelial cell functions. Recently our group demonstrated that HZ enhanced total gelatinolytic activity in endothelial cells by inducing ex novo matrix metalloproteinases-9 (MMP-9) and promoting proMMP-9 protein expression (Prato et al., 2011). …
