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02-12-2023 | Heart Failure

Can the hemodynamic model in heart failure be restored based on analysis of ventricular-arterial coupling?

Author: Johannes Soma

Published in: Heart Failure Reviews | Issue 2/2024

Abstract

The hemodynamic model was inappropriate to explain the disappointing effect of vasodilation and the beneficial effect of beta-blockade in chronic heart failure. A more nuanced hemodynamic analysis, taking both steady and pulsatile hemodynamics into consideration, improves insight into these apparently enigmatic effects. Of particular interest is the velocity of early systolic flow as a determinant of left ventricular afterload. Several drugs, in particular beta-blockers, directly or indirectly, influence the velocity of early systolic flow. Thus, the hemodynamic model in heart failure may deserve reconsideration.

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Title: Can the hemodynamic model in heart failure be restored based on analysis of ventricular-arterial coupling?
Author: Johannes Soma
Publication date: 02-12-2023
Publisher: Springer US
Keywords: Heart Failure
ß-Blockers
Atenolol
Published in: Heart Failure Reviews / Issue 2/2024
Print ISSN: 1382-4147
Electronic ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-023-10374-7

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