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Open Access 24-11-2022 | Halitosis | Review Article

Effectiveness of lasers and aPDT in elimination of intraoral halitosis: a systematic review based on clinical trials

Authors: Agnieszka Woźniak, Jacek Matys, Kinga Grzech-Leśniak

Published in: Lasers in Medical Science | Issue 9/2022

Abstract

In recent years, there has been increasing interest in research showing positive results in antimicrobial photodynamic therapy (aPDT) and laser therapy (LT) in dentistry. The authors of this review tried to answer the question: “Is the effectiveness of lasers and aPDT in the elimination of intraoral halitosis possible?” For this purpose, the electronic database of PubMed and Cochrane Library were searched until September 2021 using a combination of different keywords: (bad breath OR fetor ex ore OR halitosis OR oral malodor) AND (laser OR PDT OR PACT OR photodynamic inactivation OR photodynamic therapy OR photodynamic antimicrobial chemotherapy). Initially, 83 studies were identified. A total of 9 articles were qualified after the application of the eligibility criteria. Eight works concerned aPDT treatment, and only one dedicated to the Er,Cr:YSGG laser. A significant reduction in halitosis occurred immediately after both LT and aPDT. The review found the confirmation of the effectiveness of laser therapy in reducing the number of volatile sulfur compounds (VSC) and the amount of anaerobic bacteria responsible for VSC formation. In most studies, a positive effect was observed for a 1-week follow-up. Laser therapy (aPDT, Er,Cr:YSGG) effectively eliminates microorganisms that produce volatile compounds and can effectively eliminate bad breath for the longer period of time than traditional methods of combatting this ailment.

Silva MF, Leite FRM, Ferreira LB et al (2018) Estimated prevalence of halitosis: a systematic review and meta-regression analysis. Clin Oral Investig 22(1):47–55. https://doi.org/10.1007/s00784-017-2164-5CrossRefPubMed

do Vale KL, Horliana ACRT, Romero SDS et al (2019) Evaluation of the treatment of halitosis with photodynamic therapy in older patients with complete denture: protocol for a randomized, controlled trial. Medicine (Baltimore) 98(27):e16275. https://doi.org/10.1097/MD.0000000000016275CrossRef

K, Yaegaki, JM, Coil (2000) Examination, classification, and treatment of halitosis; clinical perspectives. J Can Dent Assoc 66(5):e16275. https://doi.org/10.12691/ijdsr-4-4-3CrossRef

Hampelska K, Jaworska MM, Babalska ZŁ, Karpiński TM (2020) The role of oral microbiota in intra-oral halitosis. J Clin Med 9(8):1–17. https://doi.org/10.3390/jcm9082484CrossRef

Kim JG, Kim YJ, Yoo SH et al (2010) Halimeter ppb levels as the predictor of erosive gastroesophageal reflux disease. Gut Liver 4(3):320–325. https://doi.org/10.5009/gnl.2010.4.3.320CrossRefPubMedPubMedCentral

Ueno M, Shinada K, Yanagisawa T et al (2008) Clinical oral malodor measurement with a portable sulfide monitor. Oral Dis 14(3):264–269. https://doi.org/10.1111/j.1601-0825.2007.01374.xCrossRefPubMed

Rosenberg M, McCulloch CAG (1992) Measurement of oral malodor: current methods and future prospects. J Periodontol 63(9):776–782. https://doi.org/10.1902/jop.1992.63.9.776CrossRefPubMed

YR, Li, M, Trush (2016) Defining ROS in biology and medicine. React Oxyg Species 1(1):9. https://doi.org/10.20455/ros.2016.803CrossRef

Grzech-Leśniak K, Nowicka J, Pajączkowska M et al (2019) Effects of Nd:YAG laser irradiation on the growth of Candida albicans and Streptococcus mutans: in vitro study. Lasers Med Sci 34(1):129–137. https://doi.org/10.1007/s10103-018-2622-6CrossRefPubMed

10.

K, Świder, M, Dominiak, K, Grzech-Leśniak, J, Matys (2019) Effect of different laser wavelengths on periodontopathogens in peri-implantitis: a review of in vivo studies. Microorganisms 7(7):189. https://doi.org/10.3390/microorganisms7070189CrossRefPubMedPubMedCentral

11.

R, Wiench, D, Skaba, J, Matys, K, Grzech-Leśniak (2021) Efficacy of toluidine blue—mediated antimicrobial photodynamic therapy on Candida spp.: a systematic review. Antibiotics 10(4):349. https://doi.org/10.3390/antibiotics10040349CrossRefPubMedPubMedCentral

12.

J, Matys, K, Świder, R, Flieger (2017) Laser instant implant impression method: a case presentation. Dent Med Probl 54(1):101. https://doi.org/10.17219/dmp/66363CrossRef

13.

Dompe C, Moncrieff L, Matys J et al (2020) Photobiomodulation—underlying mechanism and clinical applications. J Clin Med 9(6):1724. https://doi.org/10.3390/jcm9061724CrossRefPubMedPubMedCentral

14.

JG, Deeb, J, Smith, BR, Belvin, K, Grzech-Leśniak, J, Lewis (2019) Er:YAG laser irradiation reduces microbial viability when used in combination with irrigation with sodium hypochlorite, chlorhexidine, and hydrogen peroxide. Microorganisms 7(12):612. https://doi.org/10.3390/microorganisms7120612CrossRef

15.

Higgins J, Thomas2 J (2021) Cochrane handbook for systematic reviews of interventions | Cochrane Training. https://training.cochrane.org/handbook/current. Accessed August 22, 2021

16.

AC, Costa da Mota, CM, França, R, Prates et al (2016) Effect of photodynamic therapy for the treatment of halitosis in adolescents – a controlled, microbiological, clinical trial. J Biophotonics 9(11–12):1337–1343. https://doi.org/10.1002/jbio.201600067CrossRefPubMed

17.

K, Llanos do Vale, AC, Ratto Tempestini Horliana, S, Romero dos Santos et al (2021) Treatment of halitosis with photodynamic therapy in older adults with complete dentures: a randomized, controlled, clinical trial. Photodiagnosis Photodyn Ther 33:102128. https://doi.org/10.1016/j.pdpdt.2020.102128CrossRefPubMed

18.

SS, Romero, KL, do Vale, VG, Remolina et al (2021) Oral hygiene associated with antimicrobial photodynamic therapy or lingual scraper in the reduction of halitosis after 90 days follow up: a randomized, controlled, single-blinded trial. Photodiagnosis Photodyn Ther 33:102057. https://doi.org/10.1016/j.pdpdt.2020.102057CrossRefPubMed

19.

ACC, CiarciaM, MLL, Gonçalves, ACRT, Horliana et al (2019) Action of antimicrobial photodynamic therapy with red leds in microorganisms related to halitose: controlled and randomized clinical trial. Medicine (Baltimore) 98(1):e13939. https://doi.org/10.1097/MD.0000000000013939CrossRef

20.

Lopes RG, da Mota ACC, Soares C et al (2016) Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial. Lasers Med Sci 31(1):41–47. https://doi.org/10.1007/s10103-015-1822-6CrossRefPubMed

21.

N, Labban, MK, Assery, R, Al-Kattan, N, Al-Shibani, AF, Alfouzan, SM, Al Taweel (2020) Antimicrobial capacity of photodynamic therapy on oral health-related quality of life and halitosis among elderly patients wearing removal dentures. Photodiagnosis Photodyn Ther 32:102059. https://doi.org/10.1016/j.pdpdt.2020.102059CrossRefPubMed

22.

YP, Krespi, V, Kizhner, KA, Wilson et al (2021) Laser tongue debridement for oral malodor—a novel approach to halitosis. Am J Otolaryngol - Head Neck Med Surg 42(1):102458. https://doi.org/10.1016/j.amjoto.2020.102458CrossRef

23.

MLL, Gonçalves, ACC, da Mota, AM, Deana et al (2020) Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis—a randomized, controlled clinical trial. Photodiagnosis Photodyn Ther 30:101751. https://doi.org/10.1016/j.pdpdt.2020.101751CrossRefPubMed

24.

MLL, Goncalves, S, Kalil Bussadori, Y, Dadalti Fragoso et al (2017) Effect of photodynamic therapy in the reduction of halitosis in patients with multiple sclerosis: Clinical trial. J Breath Res 11(4):046004. https://doi.org/10.1088/1752-7163/aa8209CrossRef

25.

Grzech-Leśniak K, Belvin BR, Lewis JP, Golob DJ (2021) Treatment with Nd:YAG laser irradiation combined with sodium hypochlorite or hydrogen peroxide irrigation on periodontal pathogens: an in vitro study. Photobiomodulation, Photomedicine, Laser Surg 39(1):46–52. https://doi.org/10.1089/photob.2019.4775CrossRef

26.

W, Ye, Y, Zhang, M, He, C, Zhu, XP, Feng (2020) Relationship of tongue coating microbiome on volatile sulfur compounds in healthy and halitosis adults. J Breath Res 14(1):016005. https://doi.org/10.1088/1752-7163/ab47b4CrossRef

27.

I, Mogilnicka, P, Bogucki, M, Ufnal (2020) Microbiota and malodor—etiology and management. Int J Mol Sci 21(8):2886. https://doi.org/10.3390/ijms21082886CrossRefPubMedPubMedCentral

28.

Nammour S, El Mobadder M, Maalouf E et al (2021) Clinical evaluation of diode (980 nm) laser-assisted nonsurgical periodontal pocket therapy: a randomized comparative clinical trial and bacteriological study. Photobiomodulation, Photomedicine, Laser Surg 39(1):10–22. https://doi.org/10.1089/photob.2020.4818CrossRef

29.

Mantilla Gómez S, Danser MM, Sipos PM et al (2001) Tongue coating and salivary bacterial counts in healthy/gingivitis subjects and periodontitis patients. J Clin Periodontol 28(10):970–978. https://doi.org/10.1034/j.1600-051x.2001.028010970.xCrossRefPubMed

30.

Salako NO, Philip L (2010) Comparison of the use of the halimeter and the oral chroma™ in the assessment of the ability of common cultivable oral anaerobic bacteria to produce malodorous volatile sulfur compounds from cysteine and methionine. Med Princ Pract 20(1):75–79. https://doi.org/10.1159/000319760CrossRefPubMed

Title: Effectiveness of lasers and aPDT in elimination of intraoral halitosis: a systematic review based on clinical trials
Authors: Agnieszka Woźniak
Jacek Matys
Kinga Grzech-Leśniak
Publication date: 24-11-2022
Publisher: Springer London
Keywords: Halitosis
Halitosis
Diode Laser
Laser
Er,Cr:YSGG Laser
Photodynamic Therapy
Published in: Lasers in Medical Science / Issue 9/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-022-03656-3

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Effectiveness of lasers and aPDT in elimination of intraoral halitosis: a systematic review based on clinical trials

Abstract

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