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17-11-2022 | Laser | Original Article

Anti-inflammatory effect of green photobiomodulation in human adipose-derived mesenchymal stem cells

Authors: Reyhaneh Tamimi, Nadia Malek Mahmoodi, Hamid Reza Samadikhah, Saeed Hesami Tackallou, Soheila Zamanlui Benisi, Mahdi Eskandarian Boroujeni

Published in: Lasers in Medical Science | Issue 9/2022

Abstract

Photo biomodulation (PBM) as a non-invasive and safe treatment has been demonstrated the anti-inflammatory potential in a variety of cell types, including stem cells. However, further investigations using different laser parameters combined with more accurate methods such as quantitative measurement of inflammatory gene expression at the mRNA level are still necessary. The aim of this study was to evaluate the effect of 532 nm green laser on cell proliferation as well as expression of inflammatory genes in human adipose-derived mesenchymal stem cells (hADMSCs) using RNA sequencing (RNA-seq) technique and confirmatory RT-PCR. hADMSCs were cultured in DMEM low glocuse medium with 10% fetal bovine serum until the fourth passage. Cultured cells were divided in two groups: control group (no laser irradiation) and laser group, irradiated with 532 nm laser at 44 m J/cm² with an output power of 50 mW and a density of 6 mW/cm², every other day, 7 s each time. The cell viability was assessed using MTT assay 24 h after each irradiation on days 3, 5, and 7 after cell seeding, followed by performing RNA-seq and RT-PCR. The MTT assay showed that PBM increased cell proliferation on day 5 after irradiation compared to day 3 and decreased on day 7 compared to day 5. In addition, gene expression analysis in hADMSCs using RNA-seq revealed down-regulation of inflammatory genes including CSF2, CXCL2, 3, 5, 6, 8, and CCL2, 7. These results indicate that 532 nm PBM with the parameters used in this study has a time-dependent effect on hADMSCs proliferation as well as anti-inflammatory potential.

Graphical abstract

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Title: Anti-inflammatory effect of green photobiomodulation in human adipose-derived mesenchymal stem cells
Authors: Reyhaneh Tamimi
Nadia Malek Mahmoodi
Hamid Reza Samadikhah
Saeed Hesami Tackallou
Soheila Zamanlui Benisi
Mahdi Eskandarian Boroujeni
Publication date: 17-11-2022
Publisher: Springer London
Keyword: Laser
Published in: Lasers in Medical Science / Issue 9/2022
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-022-03654-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Anti-inflammatory effect of green photobiomodulation in human adipose-derived mesenchymal stem cells

Abstract

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Graphical abstract

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