Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Infection
Published in: Infection 1/2014

01-02-2014 | Case Report

Guillain–Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c

Authors: N. Scharn, T. Ganzenmueller, J. J. Wenzel, R. Dengler, A. Heim, F. Wegner

Published in: Infection | Issue 1/2014

Login to get access

Abstract

In this report, we present a case of a 50-year-old immunocompetent man with Guillain–Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (PCR) from blood and stool. Phylogenetic analysis revealed a novel HEV genotype 3 isolate closely related to other subgenotype 3c isolates from pig livers purchased in Germany. This indicates an autochthonous, potentially food-related hepatitis E and is, to our knowledge, the first report about a neurological syndrome associated with an HEV subgenotype 3c infection.
Literature
1.
McGrogan A, Madle GC, Seaman HE, de Vries CS. The epidemiology of Guillain–Barré syndrome worldwide. A systematic literature review. Neuroepidemiology. 2009;32:150–63.PubMedCrossRef
2.
van Doorn PA, Ruts L, Jacobs BC. Clinical features, pathogenesis, and treatment of Guillain–Barré syndrome. Lancet Neurol. 2008;7:939–50.PubMedCrossRef
3.
4.
5.
6.
Cronin S, McNicholas R, Kavanagh E, Reid V, O’Rourke K. Anti-glycolipid GM2-positive Guillain–Barré syndrome due to hepatitis E infection. Ir J Med Sci. 2011;180:255–7.PubMedCrossRef
7.
Kamar N, Bendall RP, Peron JM, Cintas P, Prudhomme L, Mansuy JM, et al. Hepatitis E virus and neurologic disorders. Emerg Infect Dis. 2011;17:173–9.PubMedCrossRef
8.
Loly JP, Rikir E, Seivert M, Legros E, Defrance P, Belaiche J, et al. Guillain–Barré syndrome following hepatitis E. World J Gastroenterol. 2009;15:1645–7.PubMedCrossRef
9.
Maurissen I, Jeurissen A, Strauven T, Sprengers D, De Schepper B. First case of anti-ganglioside GM1-positive Guillain–Barré syndrome due to hepatitis E virus infection. Infection. 2012;40:323–6.PubMedCrossRef
10.
Sood A, Midha V, Sood N. Guillain–Barré syndrome with acute hepatitis E. Am J Gastroenterol. 2000;95:3667–8.PubMed
11.
Tse AC, Cheung RT, Ho SL, Chan KH. Guillain–Barré syndrome associated with acute hepatitis E infection. J Clin Neurosci. 2012;19:607–8.PubMedCrossRef
12.
Purdy MA, Khudyakov YE. The molecular epidemiology of hepatitis E virus infection. Virus Res. 2011;161:31–9.PubMedCrossRef
13.
Dalton HR, Bendall R, Ijaz S, Banks M. Hepatitis E: an emerging infection in developed countries. Lancet Infect Dis. 2008;8:698–709.PubMedCrossRef
14.
Aggarwal R, Naik S. Epidemiology of hepatitis E: current status. J Gastroenterol Hepatol. 2009;24:1484–93.PubMedCrossRef
15.
Wenzel JJ, Preiss J, Schemmerer M, Huber B, Plentz A, Jilg W. Detection of hepatitis E virus (HEV) from porcine livers in Southeastern Germany and high sequence homology to human HEV isolates. J Clin Virol. 2011;52:50–4.PubMedCrossRef
16.
Colson P, Borentain P, Motte A, Lagrange X, Kaba M, Henry M, et al. First human cases of hepatitis E infection with genotype 3c strains. J Clin Virol. 2007;40:318–20.PubMedCrossRef
17.
Rose N, Lunazzi A, Dorenlor V, Merbah T, Eono F, Eloit M, et al. High prevalence of Hepatitis E virus in French domestic pigs. Comp Immunol Microbiol Infect Dis. 2011;34:419–27.PubMedCrossRef
Metadata
Title
Guillain–Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c
Authors
N. Scharn
T. Ganzenmueller
J. J. Wenzel
R. Dengler
A. Heim
F. Wegner
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 1/2014
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-013-0448-5

Other articles of this Issue 1/2014

Infection 1/2014 Go to the issue

Case Report

Colistin bladder instillation, an alternative way of treating multi-resistant Acinetobacter urinary tract infection: a case series and review of literature

Images in Infection

Cytomegalovirus oral ulcers

Correspondence

Antifungal prophylaxis following allogeneic haematopoietic stem cell transplantation: what is the role of voriconazole?

Clinical and Epidemiological Study

Emergence of Enterococcus species in the infectious microorganisms cultured from patients with endophthalmitis in South Korea

Correspondence

Effective strategy for managing H7N9 virus infection

Clinical and Epidemiological Study

Fulminant hepatitis due to human adenovirus
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Heart Failure Video

Year in Review: Heart failure and cardiomyopathies

Watch now

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits