Skip to main content
Top
Published in: Infection 1/2014

01-02-2014 | Clinical and Epidemiological Study

Fulminant hepatitis due to human adenovirus

Authors: B. A. Ronan, N. Agrwal, E. J. Carey, G. De Petris, S. Kusne, M. T. Seville, J. E. Blair, H. R. Vikram

Published in: Infection | Issue 1/2014

Login to get access

Abstract

Purpose

To describe the demographics, clinical manifestations, treatment and outcomes of patients with human adenovirus (HAdV) hepatitis.

Methods

A case of fulminant HAdV hepatitis in a patient with chronic lymphocytic leukemia receiving rituximab and fludarabine is described. We conducted a comprehensive review of the English-language literature through May, 2012 in search of definite cases of HAdV hepatitis.

Results

Eighty-nine cases were reviewed. Forty-three (48 %) were liver transplant recipients, 19 (21 %) were bone marrow transplant recipients, 11 (12 %) had received chemotherapy, five (6 %) had severe combined immunodeficiency, four (4 %) were HIV infected, two had heart transplantation, and two were kidney transplant recipients. Ninety percent (46/51) of patients presented within 6 months following transplantation. Fever was the most common initial symptom. Abdominal CT scan revealed hypodense lesions in eight of nine patients. Diagnosis was made by liver biopsy in 43 (48 %), and on autopsy in 46 (52 %). The HAdV was isolated at other sites in 54 cases. Only 24 of 89 patients (27 %) survived: 16 whose immunosuppression was reduced, six with liver re-transplantation, and two who received cidofovir and intravenous immunoglobulin.

Conclusion

HAdV hepatitis can manifest as a fulminant illness in immunocompromised hosts. Definitive diagnosis requires liver biopsy. Early consideration of a viral etiology, reduction in immunosuppression, and liver transplantation can be potentially life-saving.
Literature
2.
3.
go back to reference Matthes-Martin S, Feuchtinger T, Shaw PJ, Engelhard D, Hirsch HH, Cordonnier C, et al. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4. Transpl Infect Dis. 2011;14:555–63.CrossRef Matthes-Martin S, Feuchtinger T, Shaw PJ, Engelhard D, Hirsch HH, Cordonnier C, et al. European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4. Transpl Infect Dis. 2011;14:555–63.CrossRef
4.
5.
go back to reference Abzug MJ, Levin MJ. Neonatal adenovirus infection: four patients and review of the literature. Pediatrics. 1991;87:890–6.PubMed Abzug MJ, Levin MJ. Neonatal adenovirus infection: four patients and review of the literature. Pediatrics. 1991;87:890–6.PubMed
6.
go back to reference Arav-Boger R, Echavarria M, Forman M, Charache P, Persaud D. Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient. Pediatr Infect Dis J. 2000;19:1097–100.PubMedCrossRef Arav-Boger R, Echavarria M, Forman M, Charache P, Persaud D. Clearance of adenoviral hepatitis with ribavirin therapy in a pediatric liver transplant recipient. Pediatr Infect Dis J. 2000;19:1097–100.PubMedCrossRef
7.
go back to reference Aterman K, Embil J, Easterbrook KB, Haldane EV, Crosby J. Liver necrosis, adenovirus type 2 and thymic dysplasia. Virchows Arch A Pathol. 1973;360:155–71.CrossRef Aterman K, Embil J, Easterbrook KB, Haldane EV, Crosby J. Liver necrosis, adenovirus type 2 and thymic dysplasia. Virchows Arch A Pathol. 1973;360:155–71.CrossRef
8.
go back to reference Benyesh-Melnick M, Rosenberg HS. The isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. J Pediatr. 1964;64:83–7.PubMedCrossRef Benyesh-Melnick M, Rosenberg HS. The isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. J Pediatr. 1964;64:83–7.PubMedCrossRef
9.
go back to reference Bertheau P, Parquet N, Ferchal F, Gluckman E, Brocheriou C. Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation. Bone Marrow Transpl. 1996;17:295–8. Bertheau P, Parquet N, Ferchal F, Gluckman E, Brocheriou C. Fulminant adenovirus hepatitis after allogeneic bone marrow transplantation. Bone Marrow Transpl. 1996;17:295–8.
10.
go back to reference Brundler MA, Rodriguez-Baez N, Jaffe R, Weinberg AG, Rogers BB. Adenovirus ascending cholangiohepatitis. Pediatr Dev Pathol. 2003;6:156–9.PubMedCrossRef Brundler MA, Rodriguez-Baez N, Jaffe R, Weinberg AG, Rogers BB. Adenovirus ascending cholangiohepatitis. Pediatr Dev Pathol. 2003;6:156–9.PubMedCrossRef
11.
go back to reference Cames B, Rahier J, Burtomboy G, de Ville de Goyet J, Reding R, Lamy M, et al. Acute adenovirus hepatitis in liver transplant recipients. J Pediatr. 1992;120:33–7.PubMedCrossRef Cames B, Rahier J, Burtomboy G, de Ville de Goyet J, Reding R, Lamy M, et al. Acute adenovirus hepatitis in liver transplant recipients. J Pediatr. 1992;120:33–7.PubMedCrossRef
12.
go back to reference Carmichael GP Jr, Zahradnik JM, Moyer GH, Porter DD. Adenovirus hepatitis in an immunosuppressed adult patient. Am J Clin Pathol. 1979;71:352–5.PubMed Carmichael GP Jr, Zahradnik JM, Moyer GH, Porter DD. Adenovirus hepatitis in an immunosuppressed adult patient. Am J Clin Pathol. 1979;71:352–5.PubMed
13.
go back to reference Chakrabarti S, Collingham KE, Fegan CD, Milligan DW. Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transpl. 1999;23:1209–11.CrossRef Chakrabarti S, Collingham KE, Fegan CD, Milligan DW. Fulminant adenovirus hepatitis following unrelated bone marrow transplantation: failure of intravenous ribavirin therapy. Bone Marrow Transpl. 1999;23:1209–11.CrossRef
14.
go back to reference Chakrabarti S, Mautner V, Osman H, Collingham KE, Fegan CD, Klapper PE, et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002;100:1619–27.PubMedCrossRef Chakrabarti S, Mautner V, Osman H, Collingham KE, Fegan CD, Klapper PE, et al. Adenovirus infections following allogeneic stem cell transplantation: incidence and outcome in relation to graft manipulation, immunosuppression, and immune recovery. Blood. 2002;100:1619–27.PubMedCrossRef
15.
go back to reference Charles AK, Caul EO, Porter HJ, Oakhill A. Fatal adenovirus 32 infection in a bone marrow transplant recipient. J Clin Pathol. 1995;48:779–81.PubMedCrossRef Charles AK, Caul EO, Porter HJ, Oakhill A. Fatal adenovirus 32 infection in a bone marrow transplant recipient. J Clin Pathol. 1995;48:779–81.PubMedCrossRef
16.
go back to reference Dombrowski F, Eis-Hubinger AM, Ackermann T, Blumel J, Spengler U, Pfeifer U. Adenovirus-induced liver necrosis in a case of AIDS. Virchows Arch. 1997;431:469–72.PubMedCrossRef Dombrowski F, Eis-Hubinger AM, Ackermann T, Blumel J, Spengler U, Pfeifer U. Adenovirus-induced liver necrosis in a case of AIDS. Virchows Arch. 1997;431:469–72.PubMedCrossRef
17.
go back to reference Engelmann G, Heim A, Greil J, Schmitt CP, Flechtenmacher C, Daum E, et al. Adenovirus infection and treatment with cidofovir in children after liver transplantation. Pediatr Transpl. 2009;13:421–8.CrossRef Engelmann G, Heim A, Greil J, Schmitt CP, Flechtenmacher C, Daum E, et al. Adenovirus infection and treatment with cidofovir in children after liver transplantation. Pediatr Transpl. 2009;13:421–8.CrossRef
18.
go back to reference Faden H, Jockin H, Talty MR, Fazilli R, Barrett H. Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. Am J Pediatr Hematol/Oncol. 1985;7:15–20. Faden H, Jockin H, Talty MR, Fazilli R, Barrett H. Fatal disseminated adenovirus infection featuring liver necrosis and prolonged viremia in an immunosuppressed child with malignant histiocytosis. Am J Pediatr Hematol/Oncol. 1985;7:15–20.
19.
go back to reference Fassas AB, Buddharaju LN, Rapoport A, Cottler-Fox M, Drachenberg C, Meisenberg B, et al. Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation. Leuk Lymph. 2001;42:801–4.CrossRef Fassas AB, Buddharaju LN, Rapoport A, Cottler-Fox M, Drachenberg C, Meisenberg B, et al. Fatal disseminated adenoviral infection associated with thrombotic thrombocytopenic purpura after allogeneic bone marrow transplantation. Leuk Lymph. 2001;42:801–4.CrossRef
20.
go back to reference Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV, et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis. 1994;169:775–81.PubMedCrossRef Flomenberg P, Babbitt J, Drobyski WR, Ash RC, Carrigan DR, Sedmak GV, et al. Increasing incidence of adenovirus disease in bone marrow transplant recipients. J Infect Dis. 1994;169:775–81.PubMedCrossRef
21.
go back to reference Gupta A, Philip A, Ranga K, Cappa J, Dougherty J, Lawlor M. An interesting case of adenoviral hepatitis in a cardiac transplant recipient. Transpl Infect Dis. 2013;12:84–6.CrossRef Gupta A, Philip A, Ranga K, Cappa J, Dougherty J, Lawlor M. An interesting case of adenoviral hepatitis in a cardiac transplant recipient. Transpl Infect Dis. 2013;12:84–6.CrossRef
22.
go back to reference Hale GA, Heslop HE, Krance RA, Brenner MA, Jayawardene D, Srivastava DK, et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transpl. 1999;23:277–82.CrossRef Hale GA, Heslop HE, Krance RA, Brenner MA, Jayawardene D, Srivastava DK, et al. Adenovirus infection after pediatric bone marrow transplantation. Bone Marrow Transpl. 1999;23:277–82.CrossRef
23.
go back to reference Haura EB, Winden MA, Proia AD, Trotter JE. Fulminant hepatic failure due to disseminated adenovirus infection in a patient with chronic lymphocytic leukemia. Cancer Control. 2002;9:248–53.PubMed Haura EB, Winden MA, Proia AD, Trotter JE. Fulminant hepatic failure due to disseminated adenovirus infection in a patient with chronic lymphocytic leukemia. Cancer Control. 2002;9:248–53.PubMed
24.
go back to reference Hogan WJ, Edwards WD, Macon WR, Habermann TM. Fulminant hepatic failure secondary to adenovirus following fludarabine-based chemotherapy for non-Hodgkin’s lymphoma. Leuk Lymph. 2001;42:1145–50.CrossRef Hogan WJ, Edwards WD, Macon WR, Habermann TM. Fulminant hepatic failure secondary to adenovirus following fludarabine-based chemotherapy for non-Hodgkin’s lymphoma. Leuk Lymph. 2001;42:1145–50.CrossRef
25.
go back to reference Hough R, Chetwood A, Sinfield R, Welch J, Vora A. Fatal adenovirus hepatitis during standard chemotherapy for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2005;27:67–72.PubMedCrossRef Hough R, Chetwood A, Sinfield R, Welch J, Vora A. Fatal adenovirus hepatitis during standard chemotherapy for childhood acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2005;27:67–72.PubMedCrossRef
26.
go back to reference Ivan D, Frazier OH, Abrams J. Fatal disseminated adenoviral infection in an adult heart transplant patient. J Heart Lung Transpl. 2004;23:1209–12.CrossRef Ivan D, Frazier OH, Abrams J. Fatal disseminated adenoviral infection in an adult heart transplant patient. J Heart Lung Transpl. 2004;23:1209–12.CrossRef
27.
go back to reference Iyer A, Mathur R, Deepak BV, Sinard J. Fatal adenoviral hepatitis after rituximab therapy. Arch Pathol Lab Med. 2006;130:1557–60.PubMed Iyer A, Mathur R, Deepak BV, Sinard J. Fatal adenoviral hepatitis after rituximab therapy. Arch Pathol Lab Med. 2006;130:1557–60.PubMed
28.
go back to reference Johnson PR, Yin JA, Morris DJ, Desai M, Cinkotai KI, McKeogh MM. Fulminant hepatic necrosis caused by adenovirus type 5 following bone marrow transplantation. Bone Marrow Transpl. 1990;5:345–7. Johnson PR, Yin JA, Morris DJ, Desai M, Cinkotai KI, McKeogh MM. Fulminant hepatic necrosis caused by adenovirus type 5 following bone marrow transplantation. Bone Marrow Transpl. 1990;5:345–7.
29.
go back to reference Kaur B, Gottardo NG, Keil AD, Hallam LA, Baker DL. A rare case of adenoviral fulminant hepatic necrosis after chemotherapy. Pediatr Hematol Oncol. 2002;19:361–71.PubMedCrossRef Kaur B, Gottardo NG, Keil AD, Hallam LA, Baker DL. A rare case of adenoviral fulminant hepatic necrosis after chemotherapy. Pediatr Hematol Oncol. 2002;19:361–71.PubMedCrossRef
30.
go back to reference Koneru B, Atchison R, Jaffe R, Cassavilla A, Van Thiel DH, Starzl TE. Serological studies of adenoviral hepatitis following pediatric liver transplantation. Transpl Proc. 1990;22:1547–8. Koneru B, Atchison R, Jaffe R, Cassavilla A, Van Thiel DH, Starzl TE. Serological studies of adenoviral hepatitis following pediatric liver transplantation. Transpl Proc. 1990;22:1547–8.
31.
go back to reference Koneru B, Jaffe R, Esquivel CO, Kunz R, Todo S, Iwatsuki S, et al. Adenoviral infections in pediatric liver transplant recipients. JAMA. 1987;258:489–92.PubMedCentralPubMedCrossRef Koneru B, Jaffe R, Esquivel CO, Kunz R, Todo S, Iwatsuki S, et al. Adenoviral infections in pediatric liver transplant recipients. JAMA. 1987;258:489–92.PubMedCentralPubMedCrossRef
32.
go back to reference Krilov LR, Rubin LG, Frogel M, Gloster E, Ni K, Kaplan M, et al. Disseminated adenovirus infection with hepatic necrosis in patients with human immunodeficiency virus infection and other immunodeficiency states. Rev Infect Dis. 1990;12:303–7.PubMedCrossRef Krilov LR, Rubin LG, Frogel M, Gloster E, Ni K, Kaplan M, et al. Disseminated adenovirus infection with hepatic necrosis in patients with human immunodeficiency virus infection and other immunodeficiency states. Rev Infect Dis. 1990;12:303–7.PubMedCrossRef
33.
go back to reference Ljungman P, Ehrnst A, Bjorkstrand B, Hellstrom E, Ingelman-Sundberg H, Juliusson G, et al. Lethal disseminated adenovirus type 1 infection in a patient with chronic lymphocytic leukemia. Scand J Infect Dis. 1990;22:601–5.PubMedCrossRef Ljungman P, Ehrnst A, Bjorkstrand B, Hellstrom E, Ingelman-Sundberg H, Juliusson G, et al. Lethal disseminated adenovirus type 1 infection in a patient with chronic lymphocytic leukemia. Scand J Infect Dis. 1990;22:601–5.PubMedCrossRef
34.
go back to reference Longerich T, Haferkamp K, Tox U, Schirmacher P, Longerich T, Haferkamp K, et al. Acute liver failure in a renal transplant patient caused by adenoviral hepatitis superimposed on a fibrosing cholestatic hepatitis B. Hum Pathol. 2004;35:894–7.PubMedCrossRef Longerich T, Haferkamp K, Tox U, Schirmacher P, Longerich T, Haferkamp K, et al. Acute liver failure in a renal transplant patient caused by adenoviral hepatitis superimposed on a fibrosing cholestatic hepatitis B. Hum Pathol. 2004;35:894–7.PubMedCrossRef
35.
go back to reference McGrath D, Falagas ME, Freeman R, Rohrer R, Fairchild R, Colbach C, et al. Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis. 1998;177:459–62.PubMedCrossRef McGrath D, Falagas ME, Freeman R, Rohrer R, Fairchild R, Colbach C, et al. Adenovirus infection in adult orthotopic liver transplant recipients: incidence and clinical significance. J Infect Dis. 1998;177:459–62.PubMedCrossRef
37.
go back to reference Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, et al. Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia. Intern Med. 2006;45:975–80.PubMedCrossRef Nakazawa H, Ito T, Makishima H, Misawa N, Okiyama W, Uehara T, et al. Adenovirus fulminant hepatic failure: disseminated adenovirus disease after unrelated allogeneic stem cell transplantation for acute lymphoblastic leukemia. Intern Med. 2006;45:975–80.PubMedCrossRef
38.
go back to reference Neofytos D, Ojha A, Mookerjee B, Wagner J, Filicko J, Ferber A, et al. Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transpl. 2007;13:74–81.CrossRef Neofytos D, Ojha A, Mookerjee B, Wagner J, Filicko J, Ferber A, et al. Treatment of adenovirus disease in stem cell transplant recipients with cidofovir. Biol Blood Marrow Transpl. 2007;13:74–81.CrossRef
39.
go back to reference Niemann TH, Trigg ME, Winick N, Penick GD. Disseminated adenoviral infection presenting as acute pancreatitis. Hum Pathol. 1993;24:1145–8.PubMedCrossRef Niemann TH, Trigg ME, Winick N, Penick GD. Disseminated adenoviral infection presenting as acute pancreatitis. Hum Pathol. 1993;24:1145–8.PubMedCrossRef
40.
go back to reference Norris SH, Butler TC, Glass N, Tran R. Fatal hepatic necrosis caused by disseminated type 5 adenovirus infection in a renal transplant recipient. Am J Nephrol. 1989;9:101–5.PubMedCrossRef Norris SH, Butler TC, Glass N, Tran R. Fatal hepatic necrosis caused by disseminated type 5 adenovirus infection in a renal transplant recipient. Am J Nephrol. 1989;9:101–5.PubMedCrossRef
41.
go back to reference Ohbu M, Sasaki K, Okudaira M, Iidaka K, Aoyama Y. Adenovirus hepatitis in a patient with severe combined immunodeficiency. Acta Pathologica Japonica. 1987;37:655–64.PubMed Ohbu M, Sasaki K, Okudaira M, Iidaka K, Aoyama Y. Adenovirus hepatitis in a patient with severe combined immunodeficiency. Acta Pathologica Japonica. 1987;37:655–64.PubMed
42.
go back to reference Perez D, McCormack L, Petrowsky H, Jochum W, Mullhaupt B, Clavien PA. Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation. Transpl Infect Dis. 2007;9:318–22.PubMedCrossRef Perez D, McCormack L, Petrowsky H, Jochum W, Mullhaupt B, Clavien PA. Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation. Transpl Infect Dis. 2007;9:318–22.PubMedCrossRef
43.
go back to reference Purtilo DT, White R, Filipovich A, Kersey J, Zelkowitz L. Fulminant liver failure induced by adenovirus after bone marrow transplantation. N Engl J Med. 1985;312:1707–8.PubMedCrossRef Purtilo DT, White R, Filipovich A, Kersey J, Zelkowitz L. Fulminant liver failure induced by adenovirus after bone marrow transplantation. N Engl J Med. 1985;312:1707–8.PubMedCrossRef
44.
go back to reference Rodriguez FH Jr, Liuzza GE, Gohd RH. Disseminated adenovirus serotype 31 infection in an immunocompromised host. Am J Clin Pathol. 1984;82:615–8.PubMed Rodriguez FH Jr, Liuzza GE, Gohd RH. Disseminated adenovirus serotype 31 infection in an immunocompromised host. Am J Clin Pathol. 1984;82:615–8.PubMed
45.
go back to reference Rothenberg M, Cheung R, Ahmed A. Adenovirus-induced acute liver failure. Dig Dis Sci. 2009;54:218–21.PubMedCrossRef Rothenberg M, Cheung R, Ahmed A. Adenovirus-induced acute liver failure. Dig Dis Sci. 2009;54:218–21.PubMedCrossRef
46.
go back to reference Saad RS, Demetris AJ, Lee RG, Kusne S, Randhawa PS. Adenovirus hepatitis in the adult allograft liver. Transplantation. 1997;64:1483–5.PubMedCrossRef Saad RS, Demetris AJ, Lee RG, Kusne S, Randhawa PS. Adenovirus hepatitis in the adult allograft liver. Transplantation. 1997;64:1483–5.PubMedCrossRef
47.
go back to reference Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD. Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med. 1985;312:529–33.PubMedCrossRef Shields AF, Hackman RC, Fife KH, Corey L, Meyers JD. Adenovirus infections in patients undergoing bone-marrow transplantation. N Engl J Med. 1985;312:529–33.PubMedCrossRef
48.
go back to reference Somervaille TC, Kirk S, Dogan A, Landon GV, Mackinnon S. Fulminant hepatic failure caused by adenovirus infection following bone marrow transplantation for Hodgkin’s disease. Bone Marrow Transpl. 1999;24:99–101.CrossRef Somervaille TC, Kirk S, Dogan A, Landon GV, Mackinnon S. Fulminant hepatic failure caused by adenovirus infection following bone marrow transplantation for Hodgkin’s disease. Bone Marrow Transpl. 1999;24:99–101.CrossRef
49.
go back to reference Steiner I, Aebi C, Ridolfi Luthy A, Wagner B, Leibundgut K. Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;50:647–9.PubMedCrossRef Steiner I, Aebi C, Ridolfi Luthy A, Wagner B, Leibundgut K. Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;50:647–9.PubMedCrossRef
50.
go back to reference Terasako K, Oshima K, Wada H, Ishihara Y, Kawamura K, Sakamoto K, et al. Fulminant hepatic failure caused by adenovirus infection mimicking peliosis hepatitis on abdominal computed tomography images after allogeneic hematopoietic stem cell transplantation. Intern Med. 2012;51:405–11.PubMedCrossRef Terasako K, Oshima K, Wada H, Ishihara Y, Kawamura K, Sakamoto K, et al. Fulminant hepatic failure caused by adenovirus infection mimicking peliosis hepatitis on abdominal computed tomography images after allogeneic hematopoietic stem cell transplantation. Intern Med. 2012;51:405–11.PubMedCrossRef
51.
go back to reference Varki NM, Bhuta S, Drake T, Porter DD. Adenovirus hepatitis in two successive liver transplants in a child. Arch Pathol Lab Med. 1990;114:106–9.PubMed Varki NM, Bhuta S, Drake T, Porter DD. Adenovirus hepatitis in two successive liver transplants in a child. Arch Pathol Lab Med. 1990;114:106–9.PubMed
52.
go back to reference Wang WH, Wang HL. Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literature. Arch Pathol Lab Med. 2003;127:e246–8.PubMed Wang WH, Wang HL. Fulminant adenovirus hepatitis following bone marrow transplantation. A case report and brief review of the literature. Arch Pathol Lab Med. 2003;127:e246–8.PubMed
53.
go back to reference Wigger HJ, Blanc WA. Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. N Engl J Med. 1966;275:870–4.PubMedCrossRef Wigger HJ, Blanc WA. Fatal hepatic and bronchial necrosis in adenovirus infection with thymic alymphoplasia. N Engl J Med. 1966;275:870–4.PubMedCrossRef
54.
go back to reference Zahradnik JM, Spencer MJ, Porter DD. Adenovirus infection in the immunocompromised patient. Am J Med. 1980;68:725–32.PubMedCrossRef Zahradnik JM, Spencer MJ, Porter DD. Adenovirus infection in the immunocompromised patient. Am J Med. 1980;68:725–32.PubMedCrossRef
55.
go back to reference Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–54.PubMedCrossRef Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med. 2002;137:947–54.PubMedCrossRef
57.
go back to reference Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol. 2003;13:155–71.PubMedCrossRef Kojaoghlanian T, Flomenberg P, Horwitz MS. The impact of adenovirus infection on the immunocompromised host. Rev Med Virol. 2003;13:155–71.PubMedCrossRef
58.
go back to reference Norvell JP, Blei AT, Jovanovic BD, Levitsky J. Herpes simplex virus hepatitis: an analysis of the published literature and institutional cases. Liver Transpl. 2007;13:1428–34.PubMedCrossRef Norvell JP, Blei AT, Jovanovic BD, Levitsky J. Herpes simplex virus hepatitis: an analysis of the published literature and institutional cases. Liver Transpl. 2007;13:1428–34.PubMedCrossRef
59.
go back to reference Ljungman P. Prevention and treatment of viral infections in stem cell transplant recipients. Br J Haematol. 2002;118:44–57.PubMedCrossRef Ljungman P. Prevention and treatment of viral infections in stem cell transplant recipients. Br J Haematol. 2002;118:44–57.PubMedCrossRef
60.
go back to reference Martin-Garrido I, Carmona EM, Specks U, Limper AH. Pneumocystis pneumonia in patients treated with rituximab. Chest. 2013;144:258–65.PubMedCrossRef Martin-Garrido I, Carmona EM, Specks U, Limper AH. Pneumocystis pneumonia in patients treated with rituximab. Chest. 2013;144:258–65.PubMedCrossRef
61.
go back to reference Safa G, Darrieux L. Cerebral toxoplasmosis after rituximab therapy. JAMA Intern Med. 2013;173:924–6.PubMedCrossRef Safa G, Darrieux L. Cerebral toxoplasmosis after rituximab therapy. JAMA Intern Med. 2013;173:924–6.PubMedCrossRef
62.
go back to reference Aksoy S, Harputluoglu H, Kilickap S, Dede DS, Dizdar O, Altundag K, et al. Rituximab-related viral infections in lymphoma patients. Leuk Lymph. 2007;48:1307–12.CrossRef Aksoy S, Harputluoglu H, Kilickap S, Dede DS, Dizdar O, Altundag K, et al. Rituximab-related viral infections in lymphoma patients. Leuk Lymph. 2007;48:1307–12.CrossRef
63.
Metadata
Title
Fulminant hepatitis due to human adenovirus
Authors
B. A. Ronan
N. Agrwal
E. J. Carey
G. De Petris
S. Kusne
M. T. Seville
J. E. Blair
H. R. Vikram
Publication date
01-02-2014
Publisher
Springer Berlin Heidelberg
Published in
Infection / Issue 1/2014
Print ISSN: 0300-8126
Electronic ISSN: 1439-0973
DOI
https://doi.org/10.1007/s15010-013-0527-7

Other articles of this Issue 1/2014

Infection 1/2014 Go to the issue
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discuss last year's major advances in heart failure and cardiomyopathies.