Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Archives of Gynecology and Obstetrics
Published in: Archives of Gynecology and Obstetrics 6/2019

01-12-2019 | Goiter | Gynecologic Oncology

Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature

Authors: Molly R. Siegel, Rebecca J. Wolsky, Edwin A. Alvarez, Biftu M. Mengesha

Published in: Archives of Gynecology and Obstetrics | Issue 6/2019

Login to get access

Abstract

Purpose

To present a case of struma ovarii with a typical features and synchronous primary thyroid carcinoma and review the available literature to guide diagnosis and management of these tumors.

Methods

We present a case from our hospital of a 55-year-old woman who had an adnexal mass with features concerning for papillary thyroid carcinoma and was ultimately determined to be struma ovarii with atypical features. Subsequent thyroid imaging and biopsy revealed a primary cervical thyroid carcinoma. We performed a PubMed search of published English language articles using the search terms “malignant struma ovarii,” “metastatic struma ovarii,” “struma ovarii with malignant transformation,” “struma ovarii papillary thyroid carcinoma,” “struma ovarii follicular thyroid carcinoma,” and “struma ovarii with concurrent primary thyroid carcinoma.”

Results

Literature review included 104 studies with a total of 195 patient cases. The average age at presentation was 44.9 years. 25.1% of patients had metastatic disease at presentation, and 6.2% had synchronous primary carcinomas; all of which were located in the thyroid.

Conclusions

Thyroid carcinoma arising in struma ovarii or mature cystic teratoma should prompt clinical evaluation and imaging of the thyroid given the possibility of synchronous primaries, metastases, and recurrence.
Literature
1.
Tan A, Stewart CJR, Garrett KL, Rye M, Cohen PA (2015) Novel BRAF and KRAS mutations in papillary thyroid carcinoma arising in struma ovarii. Endocr Pathol 26(4):296–301PubMed
2.
Doganay M, Gungor T, Cavkaytar S, Sirvan L, Mollamahmutoglu L (2008) Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. Arch Gynecol Obstet 277(4):371–373PubMed
3.
Gonzalez Aguilera B, Guerrero Vazquez R, Gros Herguido N, Sanchez Gallego F, Navarro Gonzalez E (2015) The lack of consensus in management of malignant struma ovarii. Gynecol Endocrinol 31(4):258–259PubMed
4.
Dardik RB, Dardik M, Westra W, Montz FJ (1999) Malignant struma ovarii: two case reports and a review of the literature. Gynecol Oncol 73(3):447–451PubMed
5.
Khunamornpong S, Settakorn J, Sukpan K, Suprasert P, Siriaunkgul S (2015) Poorly differentiated thyroid carcinoma arising in struma ovarii. Case Rep Pathol 2015:6
6.
Brusca N, Del Duca SC, Salvatori R et al (2015) A case report of thyroid carcinoma confined to ovary and concurrently occult in the thyroid: is conservative treatment always advised? Int J Endocrinol Metab 13(1):e18220PubMedPubMedCentral
7.
Jean S, Tanyi JL, Montone K, McGrath C, Lage-Alvarez MM, Chu CS (2012) Papillary thyroid cancer arising in struma ovarii. J Obstet Gynaecol 32(3):222–226PubMed
8.
Kostoglou-Athanassiou I, Lekka-Katsouli I, Gogou L, Papagrigoriou L, Chatonides I, Kaldrymides P (2002) Malignant struma ovarii: report of a case and review of the literature. Horm Res 58(1):34–38PubMed
9.
Gobitti CSA, Bampo C, Baresic T, Giorda G, Alessandrini L, Canzonieri V, Franchin G, Borsatti E (2017) Malingnant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. Horm (Athens) 16(3):322–327
10.
Oudoux A, Leblanc E, Beaujot J, Gauthier-Kolesnikov H (2016) Treatment and follow-up of malignant struma ovarii: regarding two cases. Gynecol Oncol Rep 17:56–59PubMedPubMedCentral
11.
Leong A, Roche PJ, Paliouras M, Rochon L, Trifiro M, Tamilia M (2013) Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. J Clin Endocrinol Metab 98(12):4599–4605PubMed
12.
Roth LM, Miller AW 3rd, Talerman A (2008) Typical thyroid-type carcinoma arising in struma ovarii: a report of 4 cases and review of the literature. Int J Gynecol Pathol 27(4):496–506PubMed
13.
Young RH, Jackson A, Wells M (1994) Ovarian metastasis from thyroid carcinoma 12 years after partial thyroidectomy mimicking struma ovarii: report of a case. Int J Gynecol Pathol 13(2):181–185PubMed
14.
Roth LM, Karseladze AI (2008) Highly differentiated follicular carcinoma arising from struma ovarii: a report of 3 cases, a review of the literature, and a reassessment of so-called peritoneal strumosis. Int J Gynecol Pathol 27(2):213–222PubMed
15.
Kraemer B, Grischke EM, Staebler A, Hirides P, Rothmund R (2011) Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. Fertil Steril 95(6):2124.e2129–2112
16.
Nahn PA, Robinson E, Strassman M (2002) Conservative therapy for malignant struma ovarii. A case report. J Reprod Med 47(11):943–945PubMed
17.
Zhang XAC (2010) Thyroid-type carcinoma of struma ovarii. Arch Pathol Lab Med 134(5):786–791PubMed
18.
Soto Moreno A, Venegas EM, Rodriguez JR et al (2002) Thyroid carcinoma on an ovarian teratoma: a case report and review of the literature. Gynecol Endocrinol 16(3):207–211PubMed
19.
Marti JL, Clark VE, Harper H, Chhieng DC, Sosa JA, Roman SA (2012) Optimal surgical management of well-differentiated thyroid cancer arising in struma ovarii: a series of 4 patients and a review of 53 reported cases. Thyroid 22(4):400–406PubMed
20.
Krishnamurthy A, Ramshankar V, Vaidyalingam V, Majhi U (2013) Synchronous papillary carcinoma thyroid with malignant struma ovarii: a management dilemma. Indian J Nucl Med 28(4):243–245PubMedPubMedCentral
21.
Leite I, Cunha TM, Figueiredo JP, Felix A (2013) Papillary carcinoma arising in struma ovarii versus ovarian metastasis from primary thyroid carcinoma: a case report and review of the literature. J Radiol Case Rep 7(10):24–33PubMedPubMedCentral
22.
Ma DGN, Dahmoush L, Robinson RA (2016) Struma ovarii with malignant transformation and germline KIT Mutation: a case report and review of the literature. Int J Gynecol Pathol 35(5):442–447PubMed
23.
Boyd JC, Williams BA, Rigby MH et al (2017) Malignant struma ovarii in a 30-year old nulliparous patient. Thyroid research. 10:3PubMedPubMedCentral
24.
Middelbeek RJWONB, Nishino M, Pallotta JA (2017) Concurrent intrathyroidal thyroid cancer and thyroid cancer in struma ovarii: a case report and literature review. J Endocr Soc 1(5):396–400PubMedPubMedCentral
25.
Janszen EW, van Doorn HC, Ewing PC et al (2008) Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. Clin Med Oncol 2:147–152PubMedPubMedCentral
26.
Gomes-Lima CJ, Nikiforov YE, Lee W, Burman KD (2018) Synchronous independent papillary thyroid carcinomas in struma ovarii and the thyroid gland with different RAS mutations. J Endocr Soc. 2(8):944–948PubMedPubMedCentral
27.
Makani S, Kim W, Gaba AR (2004) Struma ovarii with a focus of papillary thyroid cancer: a case report and review of the literature. Gynecol Oncol 94(3):835–839PubMed
28.
Schmidt J, Derr V, Heinrich MC et al (2007) BRAF in papillary thyroid carcinoma of ovary (struma ovarii). Am J Surg Pathol 31(9):1337–1343PubMed
29.
Wolff EF, Hughes M, Merino MJ et al (2010) Expression of benign and malignant thyroid tissue in ovarian teratomas and the importance of multimodal management as illustrated by a BRAF-positive follicular variant of papillary thyroid cancer. Thyroid 20(9):981–987PubMedPubMedCentral
30.
Hinshaw HDSA, Desouki MM, Olawaiye AB (2012) Malignant transformation of a mature cystic ovarian teratoma into thyroid carcinoma, mucinous adenocarcinoma, and strumal carcinoid: a case report and literature review. Case Rep Obstet Gynecol 2012:269489PubMedPubMedCentral
31.
McGill J, Sturgeon C, Angelos P (2009) Metastatic struma ovarii treated with total thyroidectomy and radioiodine ablation. Endocr Pract 15(2):167–173PubMed
32.
Shrimali RK, Shaikh G, Reed NS (2012) Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. J Med Imaging Radiat Oncol 56(4):478–482PubMed
33.
Paolo G, Mary SA, John P, Abdelgadir AM, Alina RS, Ann SJ (2015) Malignant struma ovarii: a population-level analysis of a large series of 68 patients. Thyroid 25(2):211–215
34.
Steinman RA, De Castro IO, Shrayyef M et al (2013) Two cases of malignant struma ovarii with metastasis to pelvic bone. Gynecol Obstet Invest 75(2):139–144PubMed
35.
DeSimone CP, Lele SM, Modesitt SC (2003) Malignant struma ovarii: a case report and analysis of cases reported in the literature with focus on survival and I131 therapy. Gynecol Oncol 89(3):543–548PubMed
36.
Garg K, Soslow RA, Rivera M, Tuttle MR, Ghossein RA (2009) Histologically bland “extremely well differentiated” thyroid carcinomas arising in struma ovarii can recur and metastasize. Int J Gynecol Pathol 28(3):222–230PubMed
37.
Kempers RD, Dockerty MB, Hoffman DL, Bartholomew LG (1970) Struma ovarii-ascitic, hyperthyroid, and asymptomatic syndromes. Ann Intern Med 72(6):883–893PubMed
38.
de Graaff J, van Vliet MA, Miseree J (1983) Malignant struma ovarii. Eur J Obstet Gynecol Reprod Biol 16(1):31–35PubMed
39.
Pardo-Mindan FJ, Vazquez JJ (1983) Malignant struma ovarii. Light and electron microscopic study. Cancer 51(2):337–343PubMed
40.
Rosenblum NG, LiVolsi VA, Edmonds PR, Mikuta JJ (1989) Malignant struma ovarii. Gynecol Oncol 32(2):224–227PubMed
41.
Willemse PH, Oosterhuis JW, Aalders JG et al (1987) Malignant struma ovarii treated by ovariectomy, thyroidectomy, and 131I administration. Cancer 60(2):178–182PubMed
42.
Brunskill PJ, Rollason TP, Nicholson HO (1990) Malignant follicular variant of papillary struma ovarii. Histopathology 17(6):574–576PubMed
43.
Zakhem A, Aftimos G, Kreidy R, Salem P (1990) Malignant struma ovarii: report of two cases and selected review of the literature. J Surg Oncol 43(1):61–65PubMed
44.
Devaney KSR, Norris HJ, Tavassoli FA (1993) Proliferative and histologically malignant struma ovarii: a clinicopathologic study of 54 cases. Int J Gynecol Pathol 12(4):333–343PubMed
45.
Brenner W, Bohuslavizki KH, Wolf H, Sippel C, Clausen M, Henze E (1996) Radiotherapy with iodine-131 in recurrent malignant struma ovarii. Eur J Nucl Med 23(1):91–94PubMed
46.
Berghella V, Ngadiman S, Rosenberg H, Hoda S, Zuna RE (1997) Malignant struma ovarii: A case report and review of the literature. Gynecol Obstet Investig 43(1):68–72
47.
Tennvall J, Ljungberg O, Högberg T (1997) Malignant struma ovarii' with peritoneal dissemination. Histopathology 31:289–290PubMed
48.
Rose PG, Arafah B, Abdul-Karim FW (1998) Malignant struma ovarii: recurrence and response to treatment monitored by thyroglobulin levels. Gynecol Oncol 70(3):425–427PubMed
49.
Bhansali A, Jain V, Rajwanshi A, Lodha S, Dash RJ (1999) Follicular carcinoma in a functioning struma ovarii. Postgrad Med J 75(888):617–618PubMedPubMedCentral
50.
Kano H, Inoue M, Nishino T, Yoshimoto Y, Arima R (2000) Malignant struma ovarii with Graves’ disease. Gynecol Oncol 79(3):508–510PubMed
51.
Rotman-Pikielny P, Reynolds JC, Barker WC, Yen PM, Skarulis MC, Sarlis NJ (2000) Recombinant human thyrotropin for the diagnosis and treatment of a highly functional metastatic struma ovarii. J Clin Endocrinol Metab 85(1):237–244PubMed
52.
Matsuda K, Maehama T, Kanazawa K (2001) Malignant struma ovarii with thyrotoxicosis. Gynecol Oncol 82(3):575–577PubMed
53.
Kabukcuoglu F, Baksu A, Yilmaz B, Aktumen A, Evren I (2002) Malignant struma ovarii. Pathol Oncol Res 8(2):145–147PubMed
54.
Sussman SK, Kho SA, Cersosimo E, Heimann A (2002) Coexistence of malignant struma ovarii and Graves’ disease. Endocr Pract 8(5):378–380PubMed
55.
Volpi E, Ferrero A, Nasi PG, Sismondi P (2003) Malignant struma ovarii: a case report of laparoscopic management. Gynecol Oncol 90(1):191–194PubMed
56.
Griffiths AN, Jain B, Vine SJ (2004) Papillary thyroid carcinoma of struma ovarii. J Obstet Gynaecol 24(1):92–93PubMed
57.
Osmanagaoglu M, Bozkaya H, Reis A (2004) Malignant struma ovarii: a case report and review of the literature. Indian J Med Sci 58(5):206–210PubMed
58.
Zannoni GF, Gallotta V, Legge F, Tarquini E, Scambia G, Ferrandina G (2004) Pseudo-Meigs’ syndrome associated with malignant struma ovarii: a case report. Gynecol Oncol 94(1):226–228PubMed
59.
Bolat FES, Kayaselcuk F, Asian E, Tuncer I (2005) Malignant struma ovarii: a case report. Pathol Res Pract 201(5):409–412PubMed
60.
Garcia A, Castellvi J, Lopez M, Gil A, de la Torre J, Ramon-y-Cajal S (2005) Malignant struma ovarii mimic clear cell carcinoma. Arch Gynecol Obstet 271(3):251–255PubMed
61.
Flavin R, Smyth P, Crotty P et al (2007) BRAF T1799A mutation occurring in a case of malignant struma ovarii. Int J Surg Pathol 15(2):116–120PubMed
62.
Mattucci ML, Dellera A, Guerriero A, Barbieri F, Minnelli L, Furlani L (2007) Malignant struma ovarii: a case report and review of the literature. J Endocrinol Invest 30(6):517–520PubMed
63.
Hatami M, Breining D, Owers RL, Del Priore G, Goldberg GL (2008) Malignant struma ovarii–a case report and review of the literature. Gynecol Obstet Invest 65(2):104–107PubMed
64.
Lao M, Koike J, Chauhan S, Schiano M, Plata M (2008) Struma Ovarii with a focus of follicular variant of papillary thyroid cancer: a case report. W Va Med J 104(4):12–14
65.
Tomee JF, van der Heijden PF, van den Hout JH, Brinkhuis M, Veneman TF (2008) Papillary carcinoma in struma ovarii: an unusual presentation. Neth J Med 66(6):248–251PubMed
66.
Yassa L, Sadow P, Marqusee E (2008) Malignant struma ovarii. Nat Clin Pract Endocrinol Metab 4(8):469–472PubMed
67.
Celestino R, Magalhaes J, Castro P et al (2009) A follicular variant of papillary thyroid carcinoma in struma ovarii: Case report with unique molecular alterations. Histopathology. 55(4):482–487PubMed
68.
Robboy SJ, Shaco-Levy R, Peng RY et al (2009) Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. Int J Gynecol Pathol 28(5):405–422PubMed
69.
Wong LY, Diamond TH (2009) Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves’ disease. Thyroid 19(10):1125–1127PubMed
70.
Agrawal ANJ, Duggan M (2010) Papillary thyroid carcinoma arising in a struma ovarii: a case report and analysis of cases reported in the literature. Clin Ovarian Cancer 3(2):E6–E10
71.
Coyne C, Nikiforov YE (2010) RAS mutation-positive follicular variant of papillary thyroid carcinoma arising in a struma ovarii. Endocr Pathol 21(2):144–147PubMed
72.
Marcy PY, Thariat J, Benisvy D, Azuar P (2010) Lethal, malignant, metastatic struma ovarii. Thyroid 20(9):1037–1040PubMed
73.
Roth LM, Talerman A, Wadsley J, Karseladze AI (2010) Risk factors in thyroid-type carcinoma arising in ovarian struma: a report of 15 cases with comparison to ordinary struma ovarii. Histopathology 57(1):148–152PubMed
74.
Salman WD, Singh M, Twaij Z (2010) A case of papillary thyroid carcinoma in struma ovarii and review of the literature. Pathol Res Int 2010:352476
75.
Sibio S, Borrini F, Sammartino P et al (2010) Predominant Brenner tumor combined with struma ovarii containing a papillary microcarcinoma associated with benign peritoneal strumosis: report of a case and histologic features. Endocr Pathol 21(3):199–203PubMed
76.
Yucesoy G, Cakiroglu Y, Muezzinoglu B, Besnili B, Yucesoy I (2010) Malignant struma ovarii: a case report. J Korean Med Sci 25(2):327–329PubMedPubMedCentral
77.
78.
Menon S, Deodhar K, Rekhi B, John A, Maheshwari A (2011) Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. Indian J Pathol Microbiol 54(3):578–580PubMed
79.
Tanaka HSY, Kobayashi T, Yoshida K, Asakura T, Taniguchi H (2011) A case of thyroid-type papillary carcinoma derived from ovarian mature cystic teratoma, resected by laparoscopic surgery. Asian J Endosc Surg 4(2):86–89PubMed
80.
Barrera JR, Manalo LA, Ang FLL (2012) Papillary thyroid-type carcinoma arising from struma ovarii. BMJ Case Rep 2012:bcr0320126145PubMedPubMedCentral
81.
Collins AM, Bodenner D, Chen C, Stone P, Stack BC Jr (2012) Delayed treatment of papillary thyroid carcinoma arising from struma ovarii in a patient with history of bilateral salpingo-oophorectomy: a case report. Endocr Pract 18(1):e1–e4PubMed
82.
Gunasekaran S, Kopecka E, Maung KH, England RJ (2012) Struma ovarii and the thyroid surgeon. J Laryngol Otol 126(8):858–860PubMed
83.
Lee W, Yi NJ, Kim H et al (2012) Metastatic follicular struma ovarii complicating pregnancy: a case report and review of the literature. Korean J Hepato-Biliary-Pancreat Surg 16(3):123–127
84.
Meringolo D, Bianchi D, Capula C, Costante G (2012) Papillary thyroid microcarcinoma in struma ovarii. Endocrine 41(1):164–165PubMed
85.
Selvaggi F, Risio D, Waku M et al (2012) Struma ovarii with follicular thyroid-type carcinoma and neuroendocrine component: case report. World J Surg Oncol 10(1):93PubMedPubMedCentral
86.
Stanojevic B, Dzodic R, Saenko V et al (2012) Unilateral follicular variant of papillary thyroid carcinoma with unique KRAS mutation in struma ovarii in bilateral ovarian teratoma: a rare case report. BMC Cancer 12:224PubMedPubMedCentral
87.
Mardi K, Gupta N (2013) Tall cell variant of papillary carcinoma arising from strumaovarii: a rare case report. J Cancer Res Ther 9(1):119–121PubMed
88.
Matysiak-Grzes M, Fischbach J, Gut P et al (2013) Struma ovarii maligna. Neuro Endocrinol Lett 34(2):97–101PubMed
89.
Karagkounis G, Chute DJ, Nasr CE, Berber E (2014) Tall-cell variant papillary thyroid carcinoma arising from struma ovarll. Endocr Pract 20(2):e24–e27PubMed
90.
Kumar SS, Rema P, AK R, Varghese BT (2014) Thyroid type papillary carcinoma arising in a mature teratoma. Indian J Surg Oncol 5(3):168–170PubMedPubMedCentral
91.
Luo JRXC, Li ZH (2014) Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. Med (Baltim) 93(26):e147
92.
Ukita MNH, Kotani Y, Tobiume T, Koike E, Tsuji I, Suzuki A, Mandai M (2014) Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: a case report. Oncol Lett 8(6):2458–2462PubMedPubMedCentral
93.
Monti E, Mortara L, Zupo S et al (2015) Papillary thyroid cancer in a struma ovarii: a report of a rare case. Horm (Athens). 14(1):154–159
94.
Riaz S, Bashir H, Hassan A, Syed AA, Hussain M, Imtiaz S (2015) Metastatic radioiodine avid struma ovarii associated with pseudo-meigs’ syndrome. J Ayub Med Coll Abbottabad JAMC. 27(3):731–734PubMed
95.
Srbovan D, Mihailovic J, Nikoletic K, Matovina E, Solajic N (2015) Papillary carcinoma in mature teratoma of struma ovarii. J Belg Soc Radiol 99(1):76–78PubMedPubMedCentral
96.
Wei S, Baloch ZW, LiVolsi VA (2015) Pathology of struma ovarii: a report of 96 cases. Endocr Pathol 26(4):342–348PubMed
97.
Anagnostou E, Polymeris A, Morphopoulos G, Travlos A, Sarantopoulou V, Papaspyrou I (2016) An unusual case of malignant struma ovarii causing thyrotoxicosis. Eur Thyr J 5(3):207–211
98.
Fukunaga M, Ishibashi T, Koyama T et al (2016) Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. Int J Gynecol Pathol 35(4):357–361PubMed
99.
Lara C, Cuenca D, Salame L, Padilla-Longoria R, Mercado M (2016) A hormonally active malignant struma ovarii. Case Rep Oncol Med 2016:2643470PubMedPubMedCentral
100.
Williams H, Salinas E, Savage E, Samuelson M, Goodheart MJ (2016) Malignant struma ovarii with insular carcinoma: a case report and literature review. Gynecol Oncol Rep 18:1–3PubMedPubMedCentral
101.
Zhu Y, Wang C, Zhang GN et al (2016) Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. World J Surg Oncol 14(1):17PubMedPubMedCentral
102.
Llueca A, Maazouzi Y, Herraiz JL et al (2017) Treatment and follow-up in an asymptomatic malignant struma ovarii: a case report. Int J Surg Case Rep 40:113–115PubMedPubMedCentral
103.
104.
Al Hassan MS, Saafan T, El Ansari W et al (2018) The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature. Thyr Res 11:10
105.
Iranparvar Alamdari M, Habibzadeh A, Pakrouy H, Chaichi P, Sheidaei S (2018) An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: a case report. Int J Surg Case Rep 51:218–220PubMedPubMedCentral
106.
Lager CJ, Koenig RJ, Lieberman RW, Avram AM (2018) Rare clinical entity: metastatic malignant struma ovarii diagnosed during pregnancy—lessons for management. Clin Diabetes Endocrinol 4:13PubMedPubMedCentral
107.
Moayerifar MKS, Moayerifar M, Nakhochari A, Hassanzadeh Rad A, Dalili S (2018) Malignant struma ovarii in an 11-year-old girl. J Pediatr Surg Case Rep 29:1–4
108.
Wu MHF, Huang X, Tan Z, Lei C, Duan D (2018) Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: a case report. Medicine 97(51):e13867PubMedPubMedCentral
109.
Yasutake N, Noguchi H, Ibayashi Y et al (2018) The smallest reported malignant struma ovarii: a case report. Case Rep Oncol 11(3):693–698PubMedPubMedCentral
110.
Seifert P, Guhne F, Theurer S, Freesmeyer M (2019) Complete remission after single radioiodine therapy in malignant struma ovarii with bone and lymph node metastases. Clin Nucl Med 44(1):42–44PubMed
Metadata
Title
Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature
Authors
Molly R. Siegel
Rebecca J. Wolsky
Edwin A. Alvarez
Biftu M. Mengesha
Publication date
01-12-2019
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 6/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-019-05329-z

Other articles of this Issue 6/2019

Archives of Gynecology and Obstetrics 6/2019 Go to the issue

Gynecologic Oncology

Efficacy and safety of two post-operative drains: results of a prospectively randomized clinical study in breast cancer patients after breast conserving surgery

Maternal-Fetal Medicine

The impact of neuropsychiatric disease on fetal growth: a case–control study

Images in Obstetrics and Gynecology

Evaluation of the relationship between sexual functions and depressive symptoms among pregnant patients during the second trimester

General Gynecology

Recurrence and prediction of abnormal uterine bleeding and re-intervention after initial hysteroscopic treatment: a retrospective cohort study

Guidelines and Position Statements

Tissue biomechanical behavior should be considered in the risk assessment of perineal trauma at childbirth

Gynecologic Endocrinology and Reproductive Medicine

Frozen-thawed embryo transfer is better than fresh embryo transfer in GnRH antagonist cycle in women with 3–10 oocytes retrieved: a retrospective cohort study