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Journal of Neuro-Oncology

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01-08-2019 | Glioma | Clinical Study

Patterning of corpus callosum integrity in glioma observed by MRI: Effect of 2D bi-axial lamellar brain architecture

Authors: Vikas Pareek, Subhadip Paul, V. P. Subramanyam Rallabandi, Prasun K. Roy

Published in: Journal of Neuro-Oncology | Issue 1/2019

Abstract

Purpose

Corpus callosum (CC) is a main channel histologically for glioma spreading, downgrading the prognosis, the infiltration occurring through cellular reaction–diffusion process. Preliminary clinical trial indicates that CC’s surgical interruption appreciably enhances clinical outcome. We aim to find how high-grade glioma phenomenology is reflected in CC parameters, including various 3D diffusion eigenvalues differentially, whereby this information may be utilized for planning radiotherapy and surgical intervention.

Methods

Using 3 Tesla MRI diffusion-tensor imaging of glioma patients and matched controls, we formulated the callosal volume, fibre count, and 3D directional diffusivity eigenvalues (λ₁–λ₂–λ₃), utilizing FDT/FMRIB-based analysis.

Results

In glioma, the callosal volume, fibre count and normalized volume decreases (p < 0.001), while axial diffusivity λ₁ and radial diffusivity component λ₂ significantly increase (p = 0.03, p = 0.04). Though not expected, the other radial diffusivity component λ₃ remains unchanged (p = 0.11). Increase of λ₁ and λ₂ is due to gliomatous migration across the two directions (eigenvectors of λ₁, λ₂), which correlate respectively with medio-lateral commissural fibres and dorso-ventral perforating fibres in CC. These are corroborated by collateral radiological findings and immunohistological staining of those two fibre-systems in cat and human.

Conclusion

In glioma, the two diffusivities (λ₁, λ₂), enhance due to fluidic edema permeation through CC’s bi-axial lamina-type structural scaffold, formed by mediolateral commissural fibres and dorsoventral perforating cingulo-septal fibres. On other hand, the two radial diffusivities (λ₂, λ₃) are physiologically different and can be distinguished as lamellar diffusivity and focal diffusivity respectively. Lamellar diffusivity λ₂ needs to be considered for MRI-assisted surgical intervention and radiotherapy planning in glioma.

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Title: Patterning of corpus callosum integrity in glioma observed by MRI: Effect of 2D bi-axial lamellar brain architecture
Authors: Vikas Pareek
Subhadip Paul
V. P. Subramanyam Rallabandi
Prasun K. Roy
Publication date: 01-08-2019
Publisher: Springer US
Keywords: Glioma
Magnetic Resonance Imaging
Magnetic Resonance Imaging
Glioma
Radiotherapy
Glioma
Published in: Journal of Neuro-Oncology / Issue 1/2019
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-019-03217-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Patterning of corpus callosum integrity in glioma observed by MRI: Effect of 2D bi-axial lamellar brain architecture

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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