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01-09-2015 | Clinical Study

Corpus callosum involvement and postoperative outcomes of patients with gliomas

Authors: Ko-Ting Chen, Tai-Wei Erich Wu, Chi-Cheng Chuang, Yung-Hsin Hsu, Peng-Wei Hsu, Yin-Cheng Huang, Tzu-Kang Lin, Chen-Nen Chang, Shih-Tseng Lee, Chieh-Tsai Wu, Chen-Kan Tseng, Chun-Chieh Wang, Ping-Ching Pai, Kuo-Chen Wei, Pin-Yuan Chen

Published in: Journal of Neuro-Oncology | Issue 2/2015

Abstract

Corpus callosum involvement is associated with poorer survival in high grade glioma (HGG), but the prognostic value in low grade glioma (LGG) is unclear. To determine the prognostic impact of corpus callosum involvement on progression free survival (PFS) and overall survival (OS) in HGG and LGG, the records of 233 glioma patients treated from 2008 to 2011 were retrospectively reviewed. Preoperative magnetic resonance (MR) images were used to identify corpus callosum involvement. Age, sex, preoperative Karnofsky performance scale, postoperative Eastern Cooperative Oncology Group (ECOG) score and extent of resection (EOR) were evaluated with respect to PFS and OS. The incidence of corpus callosum involvement was similar among HGG (14 %) and LGG (14.5 %). Univariate analysis revealed that PFS and OS were significantly shorter in both WHO grade II and grade IV glioma with corpus callosum involvement (both, p < 0.05). Multivariate analysis showed that grade II glioma with corpus callosum involvement have shorter PFS (p = 0.03), while EOR, instead of corpus callosum involvement (p = 0.16), was an independent factor associated with PFS in grade IV glioma (p < 0.05). Corpus callosum involvement was no longer significantly associated with OS after adjusting age, gender, EOR, preoperative and postoperative performance status (p = 0.16, 0.17 and 0.56 in grade II, III and IV gliomas, respectively). Corpus callosum involvement happened in both LGG and HGG, and is associated with lower EOR and higher postoperative ECOG score both in LGG and HGG. Corpus callosum involvement tends to be an independent prognostic factor for PFS in LGG, but not for OS in LGG or in HGG.

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Title: Corpus callosum involvement and postoperative outcomes of patients with gliomas
Authors: Ko-Ting Chen
Tai-Wei Erich Wu
Chi-Cheng Chuang
Yung-Hsin Hsu
Peng-Wei Hsu
Yin-Cheng Huang
Tzu-Kang Lin
Chen-Nen Chang
Shih-Tseng Lee
Chieh-Tsai Wu
Chen-Kan Tseng
Chun-Chieh Wang
Ping-Ching Pai
Kuo-Chen Wei
Pin-Yuan Chen
Publication date: 01-09-2015
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 2/2015
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-015-1823-0

At a glance: The STEP trials

Springer Medicine

Corpus callosum involvement and postoperative outcomes of patients with gliomas

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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