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Open Access 01-12-2022 | Glioblastoma | Review

LINC00467: an oncogenic long noncoding RNA

Authors: Xuyu Chen, Qian Luo, Yanan Xiao, Jing Zhu, Yirao Zhang, Jie Ding, Juan Li

Published in: Cancer Cell International | Issue 1/2022

Abstract

Long non-coding RNAs (lncRNAs) have been found to play essential roles in the cell proliferation, fission and differentiation, involving various processes in humans. Recently, there is more and more interest in exploring the relationship between lncRNAs and tumors. Many latest evidences revealed that LINC00467, an oncogenic lncRNA, is highly expressed in lung cancer, gastric cancer, colorectal cancer, hepatocellular carcinoma, breast cancer, glioblastoma, head and neck squamous cell carcinoma, osteosarcoma, and other malignant tumors. Besides, LINC00467 expression was linked with proliferation, migration, invasion and apoptosis via the regulation of target genes and multiple potential pathways. We reviewed the existing data on the expression, downstream targets, molecular mechanisms, functions, relevant signaling pathways, and clinical implications of LINC00467 in various cancers. LINC00467 may serve as a novel biomarker or therapeutic target for the diagnosis and prognosis of various human tumors.

Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics. CA Cancer J Clin. 2021;71(2021):7–33. https://doi.org/10.3322/caac.21654.CrossRefPubMed

Veneziano D, Di Bella S, Nigita G, Laganà A, Ferro A, Croce CM. Noncoding RNA: current deep sequencing data analysis approaches and challenges. Hum Mutat. 2016;37:1283–98. https://doi.org/10.1002/humu.23066.CrossRefPubMed

Wu P, Mo Y, Peng M, Tang T, Zhong Y, Deng X, Xiong F, Guo C, Wu X, Li Y, Li X, Li G, Zeng Z, Xiong W. Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA. Mol Cancer. 2020;19:22. https://doi.org/10.1186/s12943-020-1147-3.CrossRefPubMedPubMedCentral

Djebali S, Davis CA, Merkel A, Dobin A, Lassmann T, Mortazavi A, Tanzer A, Lagarde J, Lin W, Schlesinger F, Xue C, Marinov GK, Khatun J, Williams BA, Zaleski C, Rozowsky J, Röder M, Kokocinski F, Abdelhamid RF, Alioto T, Antoshechkin I, Baer MT, Bar NS, Batut P, Bell K, Bell I, Chakrabortty S, Chen X, Chrast J, Curado J, Derrien T, Drenkow J, Dumais E, Dumais J, Duttagupta R, Falconnet E, Fastuca M, Fejes-Toth K, Ferreira P, Foissac S, Fullwood MJ, Gao H, Gonzalez D, Gordon A, Gunawardena H, Howald C, Jha S, Johnson R, Kapranov P, King B, Kingswood C, Luo OJ, Park E, Persaud K, Preall JB, Ribeca P, Risk B, Robyr D, Sammeth M, Schaffer L, See L-H, Shahab A, Skancke J, Suzuki AM, Takahashi H, Tilgner H, Trout D, Walters N, Wang H, Wrobel J, Yu Y, Ruan X, Hayashizaki Y, Harrow J, Gerstein M, Hubbard T, Reymond A, Antonarakis SE, Hannon G, Giddings MC, Ruan Y, Wold B, Carninci P, Guigó R, Gingeras TR. Landscape of transcription in human cells. Nature. 2012;489:101–8. https://doi.org/10.1038/nature11233.CrossRefPubMedPubMedCentral

Ye M, Zhang J, Wei M, Liu B, Dong K. Emerging role of long noncoding RNA-encoded micropeptides in cancer. Cancer Cell Int. 2020;20:506. https://doi.org/10.1186/s12935-020-01589-x.CrossRefPubMedPubMedCentral

Dykes IM, Emanueli C. Transcriptional and post-transcriptional gene regulation by long non-coding RNA. Genom Proteom Bioinform. 2017;15:177–86. https://doi.org/10.1016/j.gpb.2016.12.005.CrossRef

Nair L, Chung H, Basu U. Regulation of long non-coding RNAs and genome dynamics by the RNA surveillance machinery. Nat Rev Mol Cell Biol. 2020;21:123–36. https://doi.org/10.1038/s41580-019-0209-0.CrossRefPubMedPubMedCentral

Yang Y, Yujiao W, Fang W, Linhui Y, Ziqi G, Zhichen W, Zirui W, Shengwang W. The roles of miRNA, lncRNA and circRNA in the development of osteoporosis. Biol Res. 2020;53:40. https://doi.org/10.1186/s40659-020-00309-z.CrossRefPubMedPubMedCentral

Liu X-H, Sun M, Nie F-Q, Ge Y-B, Zhang E-B, Yin D-D, Kong R, Xia R, Lu K-H, Li J-H, De W, Wang K-M, Wang Z-X. Lnc RNA HOTAIR functions as a competing endogenous RNA to regulate HER2 expression by sponging miR-331–3p in gastric cancer. Molecular Cancer. 2014;13:92. https://doi.org/10.1186/1476-4598-13-92.CrossRefPubMedPubMedCentral

10.

Chen J, Hou S-F, Tang F-J, Liu D-S, Chen Z-Z, Zhang H-L, Wang S-H. HOTAIR/Sp1/miR-199a critically regulates cancer stemness and malignant progression of cutaneous squamous cell carcinoma. Oncogene. 2022. https://doi.org/10.1038/s41388-021-02014-x.CrossRefPubMedPubMedCentral

11.

Ding J, Li J, Wang H, Tian Y, Xie M, He X, Ji H, Ma Z, Hui B, Wang K, Ji G. Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. Cell Death Dis. 2017;8:e2997. https://doi.org/10.1038/cddis.2017.328.CrossRefPubMedPubMedCentral

12.

Lau E. Non-coding RNA: Zooming in on lncRNA functions. Nat Rev Genet. 2014;15:574–5. https://doi.org/10.1038/nrg3795.CrossRefPubMed

13.

Kornienko AE, Guenzl PM, Barlow DP, Pauler FM. Gene regulation by the act of long non-coding RNA transcription. BMC Biol. 2013;11:59. https://doi.org/10.1186/1741-7007-11-59.CrossRefPubMedPubMedCentral

14.

Schmitz SU, Grote P, Herrmann BG. Mechanisms of long noncoding RNA function in development and disease. Cell Mol Life Sci. 2016;73:2491–509. https://doi.org/10.1007/s00018-016-2174-5.CrossRefPubMedPubMedCentral

15.

Atmadibrata B, Liu PY, Sokolowski N, Zhang L, Wong M, Tee AE, Marshall GM, Liu T. The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc. PLoS One. 2014;9:e88112. https://doi.org/10.1371/journal.pone.0088112.CrossRefPubMedPubMedCentral

16.

Yang J, Liu Y, Mai X, Lu S, Jin L, Tai X. STAT1-induced upregulation of LINC00467 promotes the proliferation migration of lung adenocarcinoma cells by epigenetically silencing DKK1 to activate Wnt/beta-catenin signaling pathway. Biochem Biophys Res Commun. 2019;514:118–26. https://doi.org/10.1016/j.bbrc.2019.04.107.CrossRefPubMed

17.

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F, Global Cancer Statistics. GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2020;71(2021):209–49. https://doi.org/10.3322/caac.21660.CrossRef

18.

Toumazis I, Bastani M, Han SS, Plevritis SK. Risk-Based lung cancer screening: a systematic review. Lung Cancer. 2020;147:154–86. https://doi.org/10.1016/j.lungcan.2020.07.007.CrossRefPubMed

19.

Zhu Y, Li J, Bo H, He D, Xiao M, Xiang L, Gong L, Hu Y, Zhang Y, Cheng Y, Deng L, Zhu R, Ma Y, Cao K. LINC00467 is up-regulated by TDG-mediated acetylation in non-small cell lung cancer and promotes tumor progression. Oncogene. 2020;39:6071–84. https://doi.org/10.1038/s41388-020-01421-w.CrossRefPubMed

20.

Chang Y, Yang L. LINC00467 promotes cell proliferation and stemness in lung adenocarcinoma by sponging miR-4779 and miR-7978. J Cell Biochem. 2019. https://doi.org/10.1002/jcb.29510.CrossRefPubMed

21.

Ding H, Luo Y, Hu K, Liu P, Xiong M. Linc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression. Onco Targets Ther. 2019;12:6733–43. https://doi.org/10.2147/OTT.S207748.CrossRefPubMedPubMedCentral

22.

Wang X, Liu H, Shen K, Pan X, Wei Y, Lv T, Song Y. Long intergenic noncoding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression. Mol Med Rep. 2019;20:640–54. https://doi.org/10.3892/mmr.2019.10292.CrossRefPubMedPubMedCentral

23.

Wang W, Bo H, Liang Y, Li G. LINC00467 is upregulated by DNA copy number amplification and hypomethylation and shows cerna potential in lung adenocarcinoma. Front Endocrinol (Lausanne). 2021;12:802463. https://doi.org/10.3389/fendo.2021.802463.CrossRef

24.

Xue F, Yang C, Yun K, Jiang C, Cai R, Liang M, Wang Q, Bian W, Zhou H, Liu Z, Zhu L. Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway. Cell Biol Toxicol. 2021. https://doi.org/10.1007/s10565-021-09637-6.CrossRefPubMed

25.

Thrift AP, El-Serag HB. Burden of gastric cancer. Clin Gastroenterol Hepatol. 2020;18:534–42. https://doi.org/10.1016/j.cgh.2019.07.045.CrossRefPubMed

26.

Zhang X, Li M, Chen S, Hu J, Guo Q, Liu R, Zheng H, Jin Z, Yuan Y, Xi Y, Hua B. Endoscopic screening in asian countries is associated with reduced gastric cancer mortality: a meta-analysis and systematic review. Gastroenterology. 2018. https://doi.org/10.1053/j.gastro.2018.04.026.CrossRefPubMedPubMedCentral

27.

Deng LH, Zhao H, Bai LP, Xie J, Liu K, Yan F. Linc00467 promotion of gastric cancer development by directly regulating miR-7–5p expression and downstream epidermal growth factor receptor. Bioengineered. 2021;12:9484–95.CrossRef

28.

Xu L, Liu C, Ye Z, Wu C, Ding Y, Huang J. Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level. Tissue Cell. 2021;73:101644. https://doi.org/10.1016/j.tice.2021.101644.CrossRefPubMed

29.

Bai Y, Wu H, Han B, Xu K, Liu Y, Liu Y, Miao S, Zhang Y, Zhou L. Long intergenic non-protein coding RNA-467 targets microRNA-451a in human colorectal cancer. Oncol Lett. 2020;20:124. https://doi.org/10.3892/ol.2020.11987.CrossRefPubMedPubMedCentral

30.

He X, Li S, Yu B, Kuang G, Wu Y, Zhang M, He Y, Ou C, Cao P. Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer. J Cancer. 2019;10:6405–13. https://doi.org/10.7150/jca.32216.CrossRefPubMedPubMedCentral

31.

Li Z, Liu J, Chen H, Zhang Y, Shi H, Huang L, Tao J, Shen R, Wang T. Ferritin Light Chain (FTL) competes with long noncoding RNA Linc00467 for miR-133b binding site to regulate chemoresistance and metastasis of colorectal cancer. Carcinogenesis. 2020;41:467–77. https://doi.org/10.1093/carcin/bgz181.CrossRefPubMed

32.

Ge Q, Jia D, Cen D, Qi Y, Shi C, Li J, Sang L, Yang LJ, He J, Lin A, Chen S, Wang L. Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. J Clin Invest. 2021. https://doi.org/10.1172/JCI152911.CrossRefPubMedPubMedCentral

33.

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7:6. https://doi.org/10.1038/s41572-020-00240-3.CrossRefPubMed

34.

Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, Lencioni R, Koike K, Zucman-Rossi J, Finn RS. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7:7. https://doi.org/10.1038/s41572-021-00245-6.CrossRef

35.

Li W, He Y, Chen W, Man W, Fu Q, Tan H, Guo H, Zhou J, Yang P. Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509–3p/PDGFRA axis. Gene Ther. 2021;28:634–45. https://doi.org/10.1038/s41434-020-0137-9.CrossRefPubMed

36.

Zheng Y, Nie P, Xu S. Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis. J Cell Biochem. 2020;121:3135–44. https://doi.org/10.1002/jcb.29581.CrossRefPubMed

37.

Jiang W, Cheng X, Wang T, Song X, Zheng Y, Wang L. LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma. J Gene Med. 2020;22:e3134. https://doi.org/10.1002/jgm.3134.CrossRefPubMed

38.

Wang H, Guo Q, Nampoukime KB, Yang P, Ma K. Long non-coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3. J Cell Mol Med. 2020;24:3822–36. https://doi.org/10.1111/jcmm.14942.CrossRefPubMedPubMedCentral

39.

Cai K, Li T, Guo L, Guo H, Zhu W, Yan L, Li F. Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9–5p/PPARA expression. Open Biol. 2019;9:190074. https://doi.org/10.1098/rsob.190074.CrossRefPubMedPubMedCentral

40.

DeSantis CE, Ma J, Goding Sauer A, Newman LA, Jemal A. Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J Clin. 2017;67(2017):439–48. https://doi.org/10.3322/caac.21412.CrossRefPubMed

41.

Wilkinson L, Gathani T. Understanding breast cancer as a global health concern. Br J Radiol. 2022;95:20211033. https://doi.org/10.1259/bjr.20211033.CrossRefPubMed

42.

Bo H, Zhang W, Zhong X, Chen J, Liu Y, Cheong KL, Fan P, Tang S. LINC00467, driven by copy number amplification and DNA demethylation, is associated with oxidative lipid metabolism and immune infiltration in breast cancer. Oxid Med Cell Longev. 2021;2021:4586319. https://doi.org/10.1155/2021/4586319.CrossRefPubMedPubMedCentral

43.

Zhang Y, Sun Y, Ding L, Shi W, Ding K, Zhu Y. Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer. Front Oncol. 2021;11:643394. https://doi.org/10.3389/fonc.2021.643394.CrossRefPubMedPubMedCentral

44.

Larjavaara S, Mantyla R, Salminen T, Haapasalo H, Raitanen J, Jaaskelainen J, Auvinen A. Incidence of gliomas by anatomic location. Neuro Oncol. 2007;9:319–25. https://doi.org/10.1215/15228517-2007-016.CrossRefPubMedPubMedCentral

45.

Thakkar JP, Dolecek TA, Horbinski C, Ostrom QT, Lightner DD, Barnholtz-Sloan JS, Villano JL. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarker Prev. 2014;23:1985–96. https://doi.org/10.1158/1055-9965.EPI-14-0275.CrossRef

46.

Gao S, Duan H, An D, Yi X, Li J, Liao C. Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a. Cell Cycle. 2020;19:2040–53. https://doi.org/10.1080/15384101.2020.1792127.CrossRefPubMedPubMedCentral

47.

Zhang Y, Jiang X, Wu Z, Hu D, Jia J, Guo J, Tang T, Yao J, Liu H, Tang H. Long noncoding RNA LINC00467 promotes glioma progression through inhibiting P53 expression via binding to DNMT1. J Cancer. 2020;11:2935–44. https://doi.org/10.7150/jca.41942.CrossRefPubMedPubMedCentral

48.

Liang R, Tang Y. LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339–3p/IP6K2 axis. Cancer Biomark. 2020;28:169–80. https://doi.org/10.3233/CBM-190939.CrossRefPubMed

49.

Jiang XH, Liu YY. LINC00467 Promotes proliferation and invasion in glioma via interacting with miRNA-485–5p. Eur Rev Med Pharmacol Sci. 2020;24:766–72. https://doi.org/10.26355/eurrev_202001_20057.CrossRefPubMed

50.

Chauhan SS, Kaur J, Kumar M, Matta A, Srivastava G, Alyass A, Assi J, Leong I, MacMillan C, Witterick I, Colgan TJ, Shukla NK, Thakar A, Sharma MC, Siu KWM, Walfish PG, Ralhan R. Prediction of recurrence-free survival using a protein expression-based risk classifier for head and neck cancer. Oncogenesis. 2015;4:e147. https://doi.org/10.1038/oncsis.2015.7.CrossRefPubMedPubMedCentral

51.

Leemans CR, Braakhuis BJM, Brakenhoff RH. The molecular biology of head and neck cancer. Nat Rev Cancer. 2011. https://doi.org/10.1038/nrc2982.CrossRefPubMed

52.

Liang Y, Cheng G, Huang D, Yuan F. Linc00467 promotes invasion and inhibits apoptosis of head and neck squamous cell carcinoma by regulating miR-1285-3p/TFAP2A. Am J Transl Res. 2021;13:6248–59.PubMedPubMedCentral

53.

Chen Y, Ding Y. LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial-mesenchymal transition process via miR-299–5p/ubiquitin specific protease-48 axis. J Gene Med. 2020;22:e3184. https://doi.org/10.1002/jgm.3184.CrossRefPubMed

54.

Liu Z, Yang S, Chen X, Dong S, Zhou S, Xu S. LncRNA LINC00467 acted as an oncogene in esophageal squamous cell carcinoma by accelerating cell proliferation and preventing cell apoptosis via the miR-485–5p/DPAGT1 axis. J Gastroenterol Hepatol. 2021;36:721–30. https://doi.org/10.1111/jgh.15201.CrossRefPubMed

55.

Bo H, Zhu F, Liu Z, Deng Q, Liu G, Li R, Zhu W, Tan Y, Liu G, Fan J, Fan L. Integrated analysis of high-throughput sequencing data reveals the key role of LINC00467 in the invasion and metastasis of testicular germ cell tumors. Cell Death Discov. 2021;7:206. https://doi.org/10.1038/s41420-021-00588-9.CrossRefPubMedPubMedCentral

56.

Jiang H, Deng W, Zhu K, Zeng Z, Hu B, Zhou Z, Xie A, Zhang C, Fu B, Zhou X, Wang G. LINC00467 promotes prostate cancer progression via M2 macrophage polarization and the miR-494–3p/STAT3 axis. Front Oncol. 2021;11:661431. https://doi.org/10.3389/fonc.2021.661431.CrossRefPubMedPubMedCentral

57.

Li GC, Xin L, Wang YS, Chen Y. Long intervening noncoding 00467 RNA contributes to tumorigenesis by acting as a competing endogenous RNA against miR-107 in cervical cancer cells. Am J Pathol. 2019;189:2293–310. https://doi.org/10.1016/j.ajpath.2019.07.012.CrossRefPubMed

58.

Xiao J, Gong L, Xiao M, He D, Xiang L, Wang Z, Cheng Y, Deng L, Cao K. LINC00467 promotes tumor progression via regulation of the NF-kb signal axis in bladder cancer. Front Oncol. 2021;11:652206. https://doi.org/10.3389/fonc.2021.652206.CrossRefPubMedPubMedCentral

59.

Lu J, Wu X, Wang L, Li T, Sun L. Long noncoding RNA LINC00467 facilitates the progression of acute myeloid leukemia by targeting the miR-339/SKI pathway. Leuk Lymphoma. 2021;62:428–37. https://doi.org/10.1080/10428194.2020.1832667.CrossRefPubMed

60.

Czarnecka AM, Synoradzki K, Firlej W, Bartnik E, Sobczuk P, Fiedorowicz M, Grieb P, Rutkowski P. Molecular biology of osteosarcoma. Cancers. 2020. https://doi.org/10.3390/cancers12082130.CrossRefPubMedPubMedCentral

61.

Ritter J, Bielack SS. Osteosarcoma. Ann Oncol. 2010;21(Suppl 7):vii320-5. https://doi.org/10.1093/annonc/mdq276.CrossRefPubMed

62.

Ghafouri-Fard S, Shirvani-Farsani Z, Hussen BM, Taheri M. The critical roles of lncRNAs in the development of osteosarcoma. Biomed Pharmacother. 2021;135:111217. https://doi.org/10.1016/j.biopha.2021.111217.CrossRefPubMed

63.

Ma HZ, Wang J, Shi J, Zhang W, Zhou DS. LncRNA LINC00467 contributes to osteosarcoma growth and metastasis through regulating HMGA1 by directly targeting miR-217. Eur Rev Med Pharmacol Sci. 2020;24:5933–45. https://doi.org/10.26355/eurrev_202006_21486.CrossRefPubMed

64.

Yan J, Fang T, Zhang M, Zhou Q. LINC00467 facilitates osteosarcoma progression by sponging miR-217 to regulate KPNA4 expression. Int J Mol Med. 2021. https://doi.org/10.3892/ijmm.2021.4859.CrossRefPubMedPubMedCentral

65.

Bhan A, Soleimani M, Mandal SS. Long Noncoding RNA and Cancer: a New Paradigm. Cancer Res. 2017;77:3965–81. https://doi.org/10.1158/0008-5472.CAN-16-2634.CrossRefPubMedPubMedCentral

66.

Crick F. Central dogma of molecular biology. Nature. 1970;227:561–3.CrossRef

67.

Nishikura K. A-to-I editing of coding and non-coding RNAs by ADARs. Nat Rev Mol Cell Biol. 2016;17:83–96. https://doi.org/10.1038/nrm.2015.4.CrossRefPubMed

68.

Eisenberg E, Levanon EY. A-to-I RNA editing - immune protector and transcriptome diversifier. Nat Rev Genet. 2018;19:473–90. https://doi.org/10.1038/s41576-018-0006-1.CrossRefPubMed

69.

Ma S, Chen C, Ji X, Liu J, Zhou Q, Wang G, Yuan W, Kan Q, Sun Z. The interplay between m6A RNA methylation and noncoding RNA in cancer. J Hematol Oncol. 2019;12:121. https://doi.org/10.1186/s13045-019-0805-7.CrossRefPubMedPubMedCentral

70.

Sun T, Wu R, Ming L. The role of m6A RNA methylation in cancer. Biomed Pharmacother Biomed Pharmacother. 2019;112:108613. https://doi.org/10.1016/j.biopha.2019.108613.CrossRefPubMed

71.

Eichler J. Protein glycosylation. Curr Biol. 2019;29:R229–31. https://doi.org/10.1016/j.cub.2019.01.003.CrossRefPubMed

72.

Clarke SG. Protein methylation at the surface and buried deep: thinking outside the histone box. Trends Biochem Sci. 2013;38:243–52. https://doi.org/10.1016/j.tibs.2013.02.004.CrossRefPubMedPubMedCentral

73.

Taddei ML, Pardella E, Pranzini E, Raugei G, Paoli P. Role of tyrosine phosphorylation in modulating cancer cell metabolism. Biochim Biophys Acta Rev Cancer. 2020;1874:188442. https://doi.org/10.1016/j.bbcan.2020.188442.CrossRefPubMed

74.

Gong F, Chiu L-Y, Miller KM. Acetylation reader proteins: linking acetylation signaling to genome maintenance and cancer. PLoS Genet. 2016;12:e1006272. https://doi.org/10.1371/journal.pgen.1006272.CrossRefPubMedPubMedCentral

75.

Cockram PE, Kist M, Prakash S, Chen S-H, Wertz IE, Vucic D. Ubiquitination in the regulation of inflammatory cell death and cancer. Cell Death Differ. 2021;28:591–605. https://doi.org/10.1038/s41418-020-00708-5.CrossRefPubMedPubMedCentral

76.

Kim J, Piao H-L, Kim B-J, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung M-C, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018;50:1705–15. https://doi.org/10.1038/s41588-018-0252-3.CrossRefPubMedPubMedCentral

Title: LINC00467: an oncogenic long noncoding RNA
Authors: Xuyu Chen
Qian Luo
Yanan Xiao
Jing Zhu
Yirao Zhang
Jie Ding
Juan Li
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Glioblastoma
osteosarcoma
Lung Cancer
Lung Cancer
Breast Cancer
Glioblastoma
Gastric Cancer
Breast Cancer
Hepatocellular Carcinoma
Osteosarcoma
Gastric Cancer
Hepatocellular Carcinoma
Glioblastoma
Lung Cancer
Colorectal Cancer
Colorectal Cancer
Published in: Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-022-02733-5

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