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Graefe's Archive for Clinical and Experimental Ophthalmology

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16-07-2022 | Glaucoma | Glaucoma

Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer

Authors: Marta Isabel Martínez-Sánchez, Gema Bolívar, Haris Sideroudi, Miguel A. Teus

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 12/2022

Abstract

Purpose

The aim of the study is to evaluate the effect of topical prostaglandin (PG) treatment on the corneal biomechanical properties in treatment-naïve patients with either primary open-angle glaucoma (POAG) or ocular hypertension (OHT) using the Corvis ST device.

Methods

This is an observational study. We analyzed the Corvis ST dynamic corneal response parameters of our database using the newest software available. Thirty-four eyes of 34 patients were included. They were all newly diagnosed and treatment-naïve. Patients were evaluated at baseline and after 6 months of treatment with prostaglandin analogues.

Ultrasound pachymetry, Optical Coherence Tomography (OCT) and a 24–2 visual field test were performed in baseline visit. Goldman Applanation Tonometry (GAT-IOP) and Corvis ST dynamic corneal response parameters were registered at baseline and at the 6-month visit.

Results

After 6 months of treatment, the IOP decrease (Δ) values obtained with the different tonometers were ΔGAT -6.5 ± 3.7, ΔIOPnct -4.4 ± 5.7 and ΔbIOP -3.8 ± 5.4. The differences between ΔGAT vs ΔIOPnct, ΔGAT vs ΔbIOP, and ΔIOPnct vs ΔbIOP, were statistically significant (p < 0.05 for all comparisons). Statistically significant lower values of the stress–strain index (SSI) (1.77 ± 0.3 at baseline vs 1.54 ± 0.27 at the 6-month visit) were found (p = 0.0002).

Conclusion

The SSI provided by the Corvis ST seems to decrease significantly after topical prostaglandin therapy. We believe that our results support the hypothesis that topical PG therapy does decrease the corneal stiffness and thus, that the ocular hypotensive effect of these drugs is overestimated if GAT is used for IOP measurement.

Kingman S (2004) Glaucoma is second leading cause of blindness globally. Bull World Health Organ 82(11):887–888PubMedPubMedCentral

Liu J, Roberts CJ (2005) Influence of corneal biomechanical properties on intraocular pressure measurement: quantitative analysis. J Cataract Refract Surg 31(1):146–155. https://doi.org/10.1016/j.jcrs.2004.09.031CrossRefPubMed

Ehlers N, Bramsen T, Sperling S (1975) Applanation tonometry and central corneal thickness. Acta Ophthalmol 53(1):34–43. https://doi.org/10.1111/j.1755-3768.1975.tb01135.xCrossRef

Gordon MO, Beiser JA, Brandt JD et al (2002) The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol (Chicago, Ill.: 1960) 120(6):714–830. https://doi.org/10.1001/archopht.120.6.714CrossRef

De Moraes CV, Hill V, Tello C et al (2012) Lower corneal hysteresis is associated with more rapid glaucomatous visual field progression. J Glaucoma 21(4):209–213. https://doi.org/10.1097/IJG.0b013e3182071b92CrossRefPubMed

Helmy H, Leila M, Zaki AA (2016) Corneal biomechanics in asymmetrical normal-tension glaucoma. Clin Ophthalmol (Auckland, N.Z.) 10:503–510. https://doi.org/10.2147/OPTH.S93725CrossRef

Spörl E, Terai N, Haustein M, Böhm AG et al (2009) Biomechanische Zustand der Hornhaut als neuer Indikator für pathologische und strukturelle Veränderungen [Biomechanical condition of the cornea as a new indicator for pathological and structural changes]. Der Ophthalmologe: Zeitschrift der Dtsch Ophthalmologischen Ges 106(6):512–520. https://doi.org/10.1007/s00347-008-1910-0CrossRef

Doucette LP, Walter MA (2017) Prostaglandins in the eye: function, expression, and roles in glaucoma. Ophthalmic Genet 38(2):108–116. https://doi.org/10.3109/13816810.2016.1164193CrossRefPubMed

Tang W, Zhang F, Liu K et al (2019) Efficacy and safety of prostaglandin analogues in primary open-angle glaucoma or ocular hypertension patients: a meta-analysis. Medicine 98(30):e16597. https://doi.org/10.1097/MD.0000000000016597CrossRefPubMedPubMedCentral

10.

Weinreb RN, Kashiwagi K, Kashiwagi F et al (1997) Prostaglandins increase matrix metalloproteinase release from human ciliary smooth muscle cells. Invest Ophthalmol Vis Sci 38(13):2772–2780PubMed

11.

Gutiérrez-Ortiz C, Teus MA, Bolivar G (2006) Short-term effects of latanoprost on anterior chamber depth in patients with glaucoma or ocular hypertension. Invest Ophthalmol Vis Sci 47(11):4856–4859. https://doi.org/10.1167/iovs.06-0014CrossRefPubMed

12.

Wang J, Zhao Y, Yu A et al (2022) Effect of travoprost, latanoprost and bimatoprost PGF2α treatments on the biomechanical properties of in-vivo rabbit cornea. Exp Eye Res 215:108920. https://doi.org/10.1016/j.exer.2022.108920CrossRefPubMed

13.

Meda R, Wang Q, Paoloni D et al (2017) The impact of chronic use of prostaglandin analogues on the biomechanical properties of the cornea in patients with primary open-angle glaucoma. Br J Ophthalmol 101(2):120–125. https://doi.org/10.1136/bjophthalmol-2016-308432CrossRefPubMed

14.

Yasukura Y, Miki A, Maeda N et al (2021) Effect of prostaglandin analogues on corneal biomechanical parameters measured with a dynamic Scheimpflug Analyzer. J Glaucoma 30(11):996–1000. https://doi.org/10.1097/IJG.0000000000001895CrossRefPubMed

15.

Jung Y, Park HL, Oh S et al (2020) Corneal biomechanical responses detected using corvis st in primary open angle glaucoma and normal tension glaucoma. Medicine 99(7):e19126. https://doi.org/10.1097/MD.0000000000019126CrossRefPubMedPubMedCentral

16.

Tsikripis P, Papaconstantinou D, Koutsandrea C et al (2013) The effect of prostaglandin analogs on the biomechanical properties and central thickness of the cornea of patients with open-angle glaucoma: a 3-year study on 108 eyes. Drug Des Dev Ther 7:1149–1156. https://doi.org/10.2147/DDDT.S50622CrossRef

17.

Eliasy A, Chen KJ, Vinciguerra R et al (2019) Determination of corneal biomechanical behavior in-vivo for healthy eyes using CorVis ST tonometry: stress-strain index. Front Bioeng Biotechnol 7:105. https://doi.org/10.3389/fbioe.2019.00105CrossRefPubMedPubMedCentral

18.

Bolívar G, Sánchez-Barahona C, Teus M et al (2015) Effect of topical prostaglandin analogues on corneal hysteresis. Acta Ophthalmol 93(6):e495–e498. https://doi.org/10.1111/aos.12689CrossRefPubMed

19.

Amano S, Nejima R, Inoue K et al (2019) Effect of topical prostaglandins on the biomechanics and shape of the cornea. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 257(10):2213–2219. https://doi.org/10.1007/s00417-019-04435-7

20.

Scott JA, Roberts CJ, Mahmoud AM et al (2021) Evaluating the relationship of intraocular pressure and anterior chamber volume with use of prostaglandin analogues. J Glaucoma 30(5):421–427. https://doi.org/10.1097/IJG.0000000000001736CrossRefPubMed

21.

Han F, Li M, Wei P et al (2020) Effect of biomechanical properties on myopia: a study of new corneal biomechanical parameters. BMC Ophthalmol 20(1):459. https://doi.org/10.1186/s12886-020-01729-xCrossRefPubMedPubMedCentral

22.

Liu G, Rong H, Pei R et al (2020) Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population. BMC Ophthalmol 20(1):436. https://doi.org/10.1186/s12886-020-01704-6CrossRefPubMedPubMedCentral

23.

Zhao W, Shen Y, Jian W et al (2020) Comparison of corneal biomechanical properties between post-LASIK ectasia and primary keratoconus. J Ophthalmol 2020:5291485. https://doi.org/10.1155/2020/5291485CrossRefPubMedPubMedCentral

24.

Vinciguerra R, Rehman S, Vallabh NA et al (2020) Corneal biomechanics and biomechanically corrected intraocular pressure in primary open-angle glaucoma, ocular hypertension and controls. Br J Ophthalmol 104(1):121–126. https://doi.org/10.1136/bjophthalmol-2018-313493CrossRefPubMed

25.

Pillunat KR, Herber R, Spoerl E et al (2019) A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes. Acta Ophthalmol 97(7):e962–e967. https://doi.org/10.1111/aos.14115CrossRefPubMed

26.

Aoki S, Miki A, Omoto T et al (2021) Biomechanical glaucoma factor and corneal hysteresis in treated primary open-angle glaucoma and their associations with visual field progression. Invest Ophthalmol Vis Sci 62(7):4. https://doi.org/10.1167/iovs.62.7.4CrossRefPubMedPubMedCentral

27.

Sánchez-Barahona C, Bolívar G, Katsanos A et al (2019) Latanoprost treatment differentially affects intraocular pressure readings obtained with three different tonometers. Acta Ophthalmol 97(8):e1112–e1115. https://doi.org/10.1111/aos.14170CrossRefPubMed

28.

Chen S, Lopes BT, Huang W, Zheng X et al (2020) Effectiveness of 4 tonometers in measuring IOP after femtosecond laser-assisted LASIK, SMILE, and transepithelial photorefractive keratectomy. J Cataract Refract Surg 46(7):967–974. https://doi.org/10.1097/j.jcrs.0000000000000204CrossRefPubMed

29.

Garway-Heath DF, Crabb DP, Bunce C et al (2015) Latanoprost for open-angle glaucoma (UKGTS): a randomised, multicentre, placebo-controlled trial. Lancet (London, England) 385(9975):1295–1304. https://doi.org/10.1016/S0140-6736(14)62111-5CrossRef

Title: Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer
Authors: Marta Isabel Martínez-Sánchez
Gema Bolívar
Haris Sideroudi
Miguel A. Teus
Publication date: 16-07-2022
Publisher: Springer Berlin Heidelberg
Keywords: Glaucoma
Latanoprost
Measurement of Intraocular Pressure
Hypertension
Hypertension
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 12/2022
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-022-05752-0

At a glance: The STEP trials

Springer Medicine

Effect of prostaglandin analogues on the biomechanical corneal properties in patients with open-angle glaucoma and ocular hypertension measured with dynamic scheimpflug analyzer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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