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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2020 | Glaucoma | Inflammatory Disorders

Comparison of visual field defect progression in secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses

Authors: Shintaro Shirahama, Toshikatsu Kaburaki, Sachiko Takada, Hisae Nakahara, Rie Tanaka, Keiko Komae, Yujiro Fujino, Hidetoshi Kawashima, Makoto Aihara

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2020

Abstract

Purpose

To clarify the prevalence of secondary glaucoma (SG) and its speed of progression in patients with herpes simplex virus (HSV)-anterior uveitis (AU), varicella zoster virus (VZV)-AU, and cytomegalovirus (CMV)-AU.

Methods

In total, 170 patients with herpetic AU were enrolled in this retrospective observational case series. Patients with visual field (VF) defects and glaucomatous disc abnormalities were diagnosed with SG. Moreover, the speed of SG progression was defined as decreasing mean deviation (MD) values per year. SG prevalence and annual MD-value decrease were compared among the three types of herpetic AU.

Results

SG prevalence was 16%, 9%, and 72% in patients with HSV-AU, VZV-AU, and CMV-AU, respectively. Patients with CMV-AU had the highest SG prevalence (odds ratio = 3.15; 95% confidence interval = 1.15–8.65; P < 0.05). Furthermore, the annual MD-value change was significantly higher in SG caused by CMV-AU than in that caused by HSV/VZV-AU (−2.6 ± 2.4 dB/year and −0.45 ± 0.54 dB/year, respectively; P < 0.05).

Conclusions

Our results demonstrated that patients with CMV-AU may have a higher risk and faster speed of progression of SG than patients with HSV/VZV-AU. Therefore, clinicians should monitor glaucoma onset and VF-defect progression in patients with CMV-AU.

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Title: Comparison of visual field defect progression in secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses
Authors: Shintaro Shirahama
Toshikatsu Kaburaki
Sachiko Takada
Hisae Nakahara
Rie Tanaka
Keiko Komae
Yujiro Fujino
Hidetoshi Kawashima
Makoto Aihara
Publication date: 01-03-2020
Publisher: Springer Berlin Heidelberg
Keywords: Glaucoma
Herpes Virus
Human Alphaherpesvirus 3
Uveitis
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2020
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-019-04559-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of visual field defect progression in secondary Glaucoma due to anterior uveitis caused by three types of herpes viruses

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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