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BMC Complementary Medicine and Therapies

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Open Access 01-12-2024 | Review

Genus Curcuma: chemical and ethnopharmacological role in aging process

Authors: Esraa A. Elhawary, Ashaimaa Y. Moussa, Abdel Nasser B. Singab

Published in: BMC Complementary Medicine and Therapies | Issue 1/2024

Abstract

Aging or senescence is part of human life development with many effects on the physical, mental, and physiological aspects which may lead to age-related deterioration in many organs. Genus Curcuma family Zingieraceae represents one of the well-studied and medically important genera with more than eighty species. The genus is reported to contain different classes of biologically active compounds that are mainly presented in diphenylheptanoids, diphenylpentanoids, diphenylalkanoids, phenylpropene derivatives, alkaloids, flavonoids, chromones, terpenoids, phenolic acids and volatile constituents. Rhizomes and roots of such species are rich with main phytoconstituents viz. curcumin, demethoxycurcumin and bis-demethoxycurcumin. A wide variety of biological activities were demonstrated for different extracts and essential oils of genus Curcuma members including antioxidant, anti-inflammatory, cytotoxic and neuroprotective. Thus, making them as an excellent safe source for nutraceutical products and as a continuous promising area of research on lead compounds that may help in the slowing down of the aging process especially the neurologic and mental deterioration that are usually experienced upon aging. In this review different species of the genus Curcuma were summarized with their phytochemical and biological activities highlighting their role as antiaging agents. The data were collected from different search engines viz. Pubmed®, Google Scholar®, Scopus® and Web of Science® limiting the search to the period between 2003 up till now.

Butnariu M: Plant genome engineering for improved flavonoids production. Plants as Bioreactors for Industrial Molecules 2023:215–240.

Chaachouay N, Benkhnigue O, Fadli M, El Ibaoui H, El Ayadi R, Zidane L. Ethnobotanical and ethnopharmacological study of medicinal and aromatic plants used in the treatment of respiratory system disorders in the Moroccan Rif. Ethnobot Res Appl. 2019;18:1–16.

Cefalu CA. Theories and mechanisms of aging. Clin Geriat Med. 2011;27(4):491–506.CrossRef

Chakraborti S. Handbook of oxidative stress in cancer: therapeutic aspects. Singapore: Springer Nature; 2022. p. 4121. https://doi.org/10.1007/978-981-16-5422-0.

Ashraf H, Moussa A, Seleem A, Eldahshan OA, Singab A-N. UPLC-ESI/MS/MS profiling and anti-inflammatory activity of Gleditsia caspica. Arch Pharm Sci Ain Shams Uni. 2020;4(1):124–34.

Ashraf H, Moussa AY, Eldahshan OA, Singab ANB. Genus Gleditsia: a phytochemical and biological review (2015–2020). J Biol Act Prod Nat. 2022;12(1):1–23.

Trevisan K, Cristina-Pereira R, Silva-Amaral D, Aversi-Ferreira TA. Theories of aging and the prevalence of Alzheimer’s disease. BioMed Res Int. 2019;2019:1–9. https://doi.org/10.1155/2019/9171424.CrossRef

Rejeski WJ, Fanning J. Models and theories of health behavior and clinical interventions in aging: a contemporary, integrative approach. Clin Interv Aging. 2019;14:1007.PubMedPubMedCentralCrossRef

Barja G. Towards a unified mechanistic theory of aging. Exp Gerontol. 2019;124:110627.PubMedCrossRef

10.

Benameur T, Soleti R, Panaro MA, La Torre ME, Monda V, Messina G, Porro C. Curcumin as prospective anti-aging natural compound: focus on brain. Molecules. 2021;26(16):4794.PubMedPubMedCentralCrossRef

11.

Shen LR, Parnell LD, Ordovas JM, Lai CQ. Curcumin and aging. BioFactors. 2013;39(1):133–40.PubMedCrossRef

12.

Ding A-J, Zheng S-Q, Huang X-B, Xing T-K, Wu G-S, Sun H-Y, Qi S-H, Luo H-R. Current perspective in the discovery of anti-aging agents from natural products. Nat Prod Bioprospect. 2017;7:335–404.PubMedPubMedCentralCrossRef

13.

Qiao J, Wang C, Chen Y, Yu S, Liu Y, Yu S, Jiang L, Jin C, Wang X, Zhang P. Herbal/natural compounds resist hallmarks of brain aging: from molecular mechanisms to therapeutic strategies. Antioxidants. 2023;12(4):920.PubMedPubMedCentralCrossRef

14.

Gao L, Liu X, Luo X, Lou X, Li P, Li X, et al. Antiaging effects of dietary supplements and natural products. Front Pharmacol. 2023;14:1192714. https://doi.org/10.3389/fphar.2023.1192714.

15.

Bjørklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, Strus O, Smetanina K, Chirumbolo S. Natural compounds and products from an anti-aging perspective. Molecules. 2022;27(20):7084.PubMedPubMedCentralCrossRef

16.

Akbari B, Baghaei-Yazdi N, Bahmaie M, Mahdavi Abhari F. The role of plant-derived natural antioxidants in reduction of oxidative stress. BioFactors. 2022;48(3):611–33.PubMedCrossRef

17.

Benameur T, Giacomucci G, Panaro MA, Ruggiero M, Trotta T, Monda V, Pizzolorusso I, Lofrumento DD, Porro C, Messina G. New promising therapeutic avenues of curcumin in brain diseases. Molecules. 2021;27(1):236.PubMedPubMedCentralCrossRef

18.

Ayati Z, Ramezani M, Amiri MS, Moghadam AT, Rahimi H, Abdollahzade A, et al. Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review. Curr Pharma Des. 2019;25(8):871–935.

19.

Zhang J. Plantlist: looking up the status of plant scientific names based on the plant list database. R package version 0.5. 3. 2019. Accessed Nov 2023.

20.

Iweala EJ, Uche ME, Dike ED, Etumnu LR, Dokunmu TM, Oluwapelumi AE, et al. Curcuma longa (turmeric): ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles-A review. Pharmacol Res-Mod Chin Med. 2023:100222. https://doi.org/10.1016/j.prmcm.2023.100222.

21.

Paleker G. Rhizome networks: Turmeric’s global journey from haldi doodh to turmeric latte. Agenda. 2023:1–8. https://doi.org/10.1080/10130950.2023.2177554.

22.

Meghwal M, Devu S, Singh H, Goswami TK. Piperine and curcumin. In: A Centum of Valuable Plant Bioactives. 1st ed. Elsevier; 2021. p. 589–612. eBook ISBN: 9780128229248.

23.

Mathai NJ, Sony D, Mane PP, Shetty CB, Latheef L, Kamath K, et al. Antiarthritic effects of turmeric and curcumin: a revisit. Polyphenols: Prevention and Treatment of Human Disease. 2018:247–52. https://doi.org/10.1016/B978-0-12-813008-7.00020-5.

24.

Ashraf K. A comprehensive review on Curcuma longa Linn.: phytochemical, pharmacological, and molecular study. Int J Green Pharm (IJGP). 2017;11(04):671–85. https://doi.org/10.22377/ijgp.v11i04.134.

25.

Haida Z, Nakasha JJ, Sinniah UR, Hakiman M. Ethnomedicinal uses, phytochemistry, pharmacological properties and toxicology of Curcuma caesia Roxb.: a review. Adv Trad Med. 2022:1–17. https://doi.org/10.1007/s13596-022-00658-y.

26.

Sari AP, Supratman U. Phytochemistry and biological activities of Curcuma aeruginosa (Roxb.). Ind J Chem. 2022;22(2):576–98.

27.

Tungcharoen P, Sudsai T, Leejae S, Wattanapiromsakul C, Tansakul P, Tewtrakul S. Wound healing activity of Curcuma zedoaroides. Songklanakarin J Sci Technol. 2016;38(6):101–7. https://doi.org/10.1016/j.ijbiomac.2018.05.066.

28.

Lobo R, Prabhu KS, Shirwaikar A, Shirwaikar A. Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. J Pharm Pharmacol. 2009;61(1):13–21.

29.

Kityania S, Talukdar AD, Nath R, Nath D, Choudhury MD, Nizamee AMH, et al. Ethnomedicinal, phytochemical and nutra-pharmaceutical potentials of Indian arrowroot (Curcuma angustifolia Roxb). Comb Chem High Throughput Screen. 2022:880–91. https://doi.org/10.2174/1386207325666220524142858.

30.

Muzammil A, Waqas M, Umar A, Sufyan M, Rehman A, Haider A, Akram H, Khan SA, Afzal M, Wajid M. Anti-aging natural compounds and their role in the regulation of metabolic pathways leading to longevity. Mini Rev Med Chem. 2021;21(18):2630–56.PubMedCrossRef

31.

Cătană C-S, Atanasov AG, Berindan-Neagoe I. Natural products with anti-aging potential: affected targets and molecular mechanisms. Biotechnol Adv. 2018;36(6):1649–56.PubMedCrossRef

32.

Bamba Y, Yun YS, Kunugi A, Inoue H. Compounds isolated from Curcuma aromatica Salisb. inhibit human P450 enzymes. J Nat Med. 2011;65:583–7.PubMedCrossRef

33.

Pant N, Misra H, Jain D. Phytochemical investigation of ethyl acetate extract from Curcuma aromatica Salisb rhizomes. Arab J Chem. 2013;6(3):279–83.CrossRef

34.

Ahmad S, Ali M, Ansari S, Ahmed F. Chemical constituents from the rhizomes of Curcuma aromatica Salisb. Der Pharma Chem. 2011;3(2):505–11.

35.

Araújo CC, Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz Rio de Janerio. 2001;96:723–8.

36.

Abdel-Lateef E, Mahmoud F, Hammam O, El-Ahwany E, El-Wakil E, Kandil S, et al. Bioactive chemical constituents of Curcuma longa L. rhizomes extract inhibit the growth of human hepatoma cell line (HepG₂). Acta Pharma. 2016;66(3):387–3980.

37.

Malek SNA, Lee GS, Hong SL, Yaacob H, Wahab NA, Faizal Weber J-F, et al. Phytochemical and cytotoxic investigations of Curcuma mangga rhizomes. Molecules. 2011;16(6):4539–48.

38.

Suksamrarn A, Eiamong S, Piyachaturawat P, Charoenpiboonsin J. Phenolic diarylheptanoids from Curcuma xanthorrhiza. Phytochemistry. 1994;36(6):1505–8.CrossRef

39.

Chen J-J, Tsai T-H, Liao H-R, Chen L-C, Kuo Y-H, Sung P-J, et al. New sesquiterpenoids and anti-platelet aggregation constituents from the rhizomes of Curcuma zedoaria. Molecules. 2016;21(10):1385.

40.

Jang MK, Lee HJ, Kim JS, Ryu J-H. A curcuminoid and two sesquiterpenoids from Curcuma zedoaria as inhibitors of nitric oxide synthesis in activated macrophages. Arch Pharm Res. 2004;27:1220–5.PubMedCrossRef

41.

Gupta A, Gupta M, Kumar S. Simultaneous determination of curcuminoids in Curcuma samples using high performance thin layer chromatography. J Liq Chromatogr Relat Technol. 1999;22(10):1561–9.CrossRef

42.

Ramirez-Ahumada Mdel C, Timmermann BN, Gang DR. Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry. 2006;67(18):2017–29. https://doi.org/10.1016/j.phytochem.2006.06.028.

43.

Liu Y, Nair MG. Curcuma longa and Curcuma mangga leaves exhibit functional food property. Food Chem. 2012;135(2):634–40.PubMedCrossRef

44.

Park B-S, Kim J-G, Kim M-R, Lee S-E, Takeoka GR, Oh K-B, et al. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric Food Chem. 2005;53(23):9005–9.

45.

Li W, Wang S, Feng J, Xiao Y, Xue X, Zhang H, et al. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson Chem. 2009;47(10):902–8.

46.

Kita T, Imai S, Sawada H, Seto H. Isolation of dihydrocurcuminoids from cell clumps and their distribution in various parts of turmeric (Curcuma longa). Biosci Biotechnol Biochem. 2009;73(5):1113–7.PubMedCrossRef

47.

Li J, Zhao F, Li MZ, Chen LX, Qiu F. Diarylheptanoids from the rhizomes of Curcuma kwangsiensis. J Nat Prod. 2010;73(10):1667–71.PubMedCrossRef

48.

Septaningsih DA, Darusman LK, Afendi FM, Heryanto R. Liquid chromatography mass spectrometry (LC-MS) fingerprint combined with chemometrics for identification of metabolites content and biological activities of Curcuma aeruginosa. Ind J Chem. 2018;18(1):43–52.

49.

Masuda T, Jitoe A, Isobe J, Nakatani N, Yonemori S. Anti-oxidative and anti-inflammatory curcumin-related phenolics from rhizomes of Curcuma domestica. Phytochemistry. 1993;32(6):1557–60.CrossRef

50.

Park S-Y, Kim DS. Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: a drug discovery effort against Alzheimer’s disease. J Nat Prod. 2002;65(9):1227–31.PubMedCrossRef

51.

Wang X, Jiang Y, Wang Y-W, Huang M-T, Ho C-T, Huang Q. Enhancing anti-inflammation activity of curcumin through O/W nanoemulsions. Food Chem. 2008;108(2):419–24.PubMedCrossRef

52.

Li R, Xiang C, Ye M, Li H-F, Zhang X, Guo D-A. Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species. Food Chem. 2011;126(4):1890–5.PubMedCrossRef

53.

Xiao J, Nian S, Huang Q. Assembly of kafirin/carboxymethyl chitosan nanoparticles to enhance the cellular uptake of curcumin. Food Hydrocoll. 2015;51:166–75.CrossRef

54.

Dao TT, Nguyen PH, Won HK, Kim EH, Park J, Won BY, et al. Curcuminoids from Curcuma longa and their inhibitory activities on influenza A neuraminidases. Food Chem. 2012;134(1):21–8.

55.

Wang L-Y, Zhang M, Zhang C-F, Wang Z-T. Diaryl derivatives from the root tuber of Curcuma longa. Biochem Sys Ecol. 2008;5(36):476–80.CrossRef

56.

Sun W, Wang S, Zhao W, Wu C, Guo S, Gao H, et al. Chemical constituents and biological research on plants in the genus Curcuma. Crit Rev Food Sci Nutr. 2017;57(7):1451–523.

57.

Xia Q, Zhao KJ, Huang ZG, Zhang P, Dong TT, Li SP, Tsim KW. Molecular genetic and chemical assessment of Rhizoma Curcumae in China. J Agric Food Chem. 2005;53(15):6019–26.PubMedCrossRef

58.

Huang X, Qin F, Zhang H-M, Xiao H-B, Wang L-X, Zhang X-Y, Ren P. Cardioprotection by Guanxin II in rats with acute myocardial infarction is related to its three compounds. J Ethnopharmacol. 2009;121(2):268–73.PubMedCrossRef

59.

Ma Z-J, Meng Z-K, Zhang P. Chemical constituents from the radix of Curcuma wenyujin. Fitoterapia. 2009;80(6):374–6.PubMedCrossRef

60.

Wang R, Li Y-B, Li Y-H, Xu Y. Wu H-l, Li X-J: Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res. 2008;1210:84–91.PubMedCrossRef

61.

Chokchaisiri R, Innok P, Suksamrarn A. Flavonoid glycosides from the aerial parts of Curcuma comosa. Phytochem Lett. 2012;5(2):361–6.CrossRef

62.

Kim DW, Lee SM, Woo HS, Park J-Y, Ko BS, Heo JD, et al. Chemical constituents and anti-inflammatory activity of the aerial parts of Curcuma longa. J Funct Food. 2016;26:485–93.

63.

Sugita P, Octaviana N, Wukirsari T, Rahayu D. Chemical constituent and antioxidant activity of methanol extract from Indonesian Curcuma aeruginosa Roxb. rhizome. Drug Invent Today. 2018;10(1):293–7.

64.

Yuan H-L, Zhao Y-L, Ding C-F, Zhu P-F, Jin Q, Liu Y-P, et al. Anti-inflammatory and antinociceptive effects of Curcuma kwangsiensis and its bioactive terpenoids in vivo and in vitro. J Ethnopharmacol. 2020;259:112935.

65.

Zhou C-X, Zhang L-S, Chen F-F, Wu H-S, Mo J-X, Gan L-S. Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells. Fitoterapia. 2017;121:141–5.PubMedCrossRef

66.

Zohmachhuana A, Lalnunmawia F, Mathipi V, Lalrinzuali K, Kumar NS. Curcuma aeruginosa Roxb. exhibits cytotoxicity in A-549 and HeLa cells by inducing apoptosis through caspase-dependent pathways. Biomed Pharmacother. 2022;150:113039. https://doi.org/10.1016/j.biopha.2022.113039.

67.

Gandhi R, Vig O, Mukherji S. Terpenoids—VI: a novel unambiguous synthesis of DL-ar-turmerone. Tetrahedron. 1959;7(3–4):236–40.

68.

Liu Y, Ma J, Wang Y, Donkor PO, Li Q, Gao S, et al. Eudesmane-type sesquiterpenes from Curcuma phaeocaulis and their inhibitory activities on nitric oxide production in RAW 264.7 cells. Eu J Org Chem. 2014;2014(25):5540–8.

69.

Shiobara Y, Asakawa Y, Kodama M, Yasuda K, Takemoto T. Curcumenone, curcumanolide A and curcumanolide B, three sesquiterpenoids from Curcuma zedoaria. Phytochemistry. 1985;24(11):2629–33.CrossRef

70.

Klau ME, Rohaeti E, Rafi M, Artika IM, Ambarsari L, Nurcholis W. Metabolite profiling of Curcuma xanthorriza varieties grown in different regions using UHPLC-Q-Orbitrap-HRMS and chemometrics analysis. Biointerface Res Appl Chem. 2023;13:1–13.

71.

Ganur AN, Kurniawanti K, Sugita P, Ambarsari L, Syahbirin G, Ilmiawati A, et al. Identified compounds from ethyl acetate phase of temu mangga (Curcuma mangga Val.) using LC-MS/MS and their potential as anticancer against MCF-7 cells. Trop J Nat Prod Res. 2022;6(12):1941–6. https://doi.org/10.26538/tjnpr/v6i12.7.

72.

Ganur AN, Rahayu DU, Dianhar H, Irwanto I, Sugita P. Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells. In: AIP Conference Proceedings. AIP Publishing; 2021. https://doi.org/10.1063/5.0051538.

73.

Siddaraju MN, Dharmesh SM. Inhibition of gastric H+, K+-ATPase and Helicobacter pylori growth by phenolic antioxidants of Zingiber officinale. Mol Nutr Food Res. 2007;51(3):324–32.PubMedCrossRef

74.

Chen J-J, Tsai C-S, Hwang T-L, Shieh P-C, Chen J-F, Sung P-J. Sesquiterpenes from the rhizome of Curcuma longa with inhibitory activity on superoxide generation and elastase release by neutrophils. Food Chem. 2010;119(3):974–80.CrossRef

75.

Khumaida N, Syukur M, Bintang M, Nurcholis W. Phenolic and flavonoid content in ethanol extract and agro-morphological diversity of Curcuma aeruginosa accessions growing in West Java. Indonesia Biodivers J Biol Divers. 2019;20(3):656–63.CrossRef

76.

Hayat S, Sabri AN. Screening for antibiofilm and antioxidant potential of turmeric (Curcuma longa) extracts. Pak J Pharma Sci. 2016;29(4):1163–70.

77.

Kumar A, Singh AK, Kaushik MS, Mishra SK, Raj P, Singh PK, et al. Interaction of turmeric (Curcuma longa L.) with beneficial microbes: a review. 3 Biotech. 2017;7(6):357. https://doi.org/10.1007/s13205-017-0971-7.

78.

Thankam SR, Manuel SG. Identification and characterization of endophytic bacteria isolated from Curcuma longa. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences. 2023. p. 93. https://doi.org/10.1007/s40011-023-01466-3.

79.

Muazzam K, Darah I. The evaluation of antibacterial activity of fungal endophyte Ceratobasidium ramicola IBRLCM127 colonizing in rhizomes of medicinal plant, Curcuma mangga Valeton & Zijp. In: IOP Conference Series: Earth and Environmental Science: 2020. IOP Publishing; 2020. p. 012083. https://doi.org/10.1088/1755-1315/596/1/012083.

80.

Krishnapura PR, Belur PD. L-Asparaginase production using solid-state fermentation by an endophytic Talaromyces pinophilus isolated from rhizomes of Curcuma amada. J Pure Appl Microbiol. 2020;14(1):307–18. https://doi.org/10.22207/JPAM.14.1.32.

81.

Krishnapura PR, Belur PD. Partial purification and characterization of L-asparaginase from an endophytic Talaromyces pinophilus isolated from the rhizomes of Curcuma amada. J Mol Catal B: Enzymatic. 2016;124:83–91.CrossRef

82.

Rahman KAMA, Ibrahim D. Ceratobasidium ramicola IBRLCM127, an endophytic fungus isolated from Curcuma mangga Valeton & Zijp with strong anti-candidal activity. J Appl Pharma Sci. 2019;9(11):086–92.CrossRef

83.

Rachman F, Septiana E, Lekatompessy S, Widowati T, Sukiman HI, Simanjuntak P. Screening for endophytic fungi from turmeric plant (Curcuma longa L.) of Sukabumi and Cibinong with potency as antioxidant compounds producer. Pak J Biol Sci: PJBS. 2015;18(1):42–5.PubMed

84.

Yan J, Qi N, Wang S, Gadhave K, Yang S. Characterization of secondary metabolites of an endophytic fungus from Curcuma wenyujin. Curr Microbiol. 2014;69:740–4.PubMedCrossRef

85.

Wang Y, Xu L, Ren W, Zhao D, Zhu Y, Wu X. Bioactive metabolites from Chaetomium globosum L18, an endophytic fungus in the medicinal plant Curcuma wenyujin. Phytomedicine. 2012;19(3–4):364–8.PubMedCrossRef

86.

Maehara S, Ikeda M, Haraguchi H, Kitamura C, Nagoe T, Ohashi K, et al. Microbial conversion of curcumin into colorless hydroderivatives by the endophytic fungus Diaporthe sp. associated with Curcuma longa. Chem Pharma Bull. 2011;59(8):1042–4. https://doi.org/10.1248/cpb.59.1042.

87.

Balaji S, Chempakam B. Toxicity prediction of compounds from turmeric (Curcuma longa L). Food Chem Toxicol. 2010;48(10):2951–9.PubMedCrossRef

88.

Kartini S, Juariah S, Mardhiyani D, Bakar MFA, Bakar FIA, Endrini S. Phytochemical properties, antioxidant activity and α-amilase inhibitory of Curcuma caesia. J Adv Res Appl Sci Eng Technol. 2023;30(1):255–63.

89.

Borah A, Paw M, Gogoi R, Loying R, Sarma N, Munda S, et al. Chemical composition, antioxidant, anti-inflammatory, anti-microbial and in-vitro cytotoxic efficacy of essential oil of Curcuma caesia Roxb. leaves: An endangered medicinal plant of North East India. Ind Crop Prod. 2019;129:448–54.

90.

Wuttikul K, Sainakham M. In vitro bioactivities and preparation of nanoemulsion from coconut oil loaded Curcuma aromatica extracts for cosmeceutical delivery systems. Saudi J Biol Sci. 2022;29(12):103435.

91.

Kusumadewi AP, Martien R, Pramono S, Setyawan AA, Windarsih A, Rohman A. Application of FTIR spectroscopy and chemometrics for correlation of antioxidant activities, phenolics and flavonoid contents of Indonesian Curcuma xanthorrhiza. Int J Food Prop. 2022;25(1):2364–72.CrossRef

92.

Setyowati E, Ikawati Z, Hertiani T, Pramantara I. Antioxidant activity and lipase enzyme inhibition of Gynura procumbens (Lour.) Merr. and Curcuma xanthorrhiza Roxb. and their correlation with chemometric methods. Health Environment Res On. 2020;2845–54. https://doi.org/10.31838/ijpr/2020.SP2.294.

93.

Mekonnen A, Desta W. Comparative study of the antioxidant and antibacterial activities of Rumex abyssinicus with commercially available Zingiber officinale and Curcuma longa in Bahir Dar city. Ethiopia Chem Biol Technol Agric. 2021;8:1–11.

94.

Akter J, Hossain MA, Takara K, Islam MZ, Hou D-X. Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds. Comp Biochem Physiol C: Toxicol Pharmacol. 2019;215:9–17.PubMed

95.

Fernandes F, Barroso MF, De Simone A, Emriková E, Dias-Teixeira M, Pereira JP, Chlebek J, Fernandes VC, Rodrigues F, Andrisano V. Multi-target neuroprotective effects of herbal medicines for Alzheimer’s disease. J Ethnopharmacol. 2022;290:115107.

96.

Sudha N, Vanisree AJ. Neuroprotective role of Curcuma amada in F₁ progeny of Juvenile Danio rerio (Zebrafish) from nickel chloride induced maternal stress in gestationally challenged adult fishes. Res J Pharm Technol. 2021;14(8):4215–20.

97.

Pintatum A, Maneerat W, Logie E, Tuenter E, Sakavitsi ME, Pieters L, et al. In vitro anti-inflammatory, anti-oxidant, and cytotoxic activities of four Curcuma species and the isolation of compounds from Curcuma aromatica rhizome. Biomolecules. 2020;10(5):799.

98.

Abimbola O, Ahmad M, Temitayo O. Anti-inflammatory actions and Salmonella typhimurium-bacteraemia clearance by methanol extract of Curcuma longa Linn. (turmeric). Mal J Microbiol. 2019;15(1):24–33.

99.

Doan CC, Le TL, Ho NQC, La THL, Nguyen VC, Nguyen TPT, et al. Bioactive chemical constituents, in vitro anti-proliferative activity and in vivo toxicity of the extract of Curcuma singularis Gagnep rhizomes. J Ethnopharmacol. 2022;284:114803.

100.

Alamri AH, Debnath S, Alqahtani T, Alqahtani A, Alshehri SA, Ghosh A. Enhancing plant-derived smart nano inhibitor in targeting mammalian target of rapamycin (mTOR) in breast cancer using Curcuma longa-derived compound curcumin. Environment Sci Pollut Res Int. 2023. https://doi.org/10.1007/s11356-023-25375-0. Advance online publication.

101.

Salehi B, Rodrigues CF, Peron G, Dall’Acqua S, Sharifi-Rad J, Azmi L, Shukla I, Singh Baghel U, Prakash Mishra A, Elissawy AM. Curcumin nanoformulations for antimicrobial and wound healing purposes. Phytother Res. 2021;35(5):2487–99.

102.

Nugraha AP, Yudianto DO, Anwar AA, Purnamasari AE, Mappananrang RA, Faradilla N, Luthfi M. Noor TNEBT, Nugraha AP, Nugraha AP: Potential of curcumin-quercetin loaded nanostructured lipid carriers as oral squamous cell carcinoma adjuvant therapy by downregulating AKT/PI3K signaling pathway. Res J Pharm Technol. 2022;15(11):5353–8.CrossRef

103.

Parida R, Nayak S. Anti-proliferative activity of in vitro Zingiberaceae essential oil against human cervical cancer (HeLa) cell line. Res J Pharm Technol. 2022;15(1):325–8.CrossRef

104.

Nag A. Evaluation of cytotoxicity and antioxidant properties of some Zingiberaceae plants. Int J Green Pharm (IJGP). 2018;12(04):870–5. https://doi.org/10.22377/ijgp.v12i04.2268.CrossRef

105.

Sumathi S. Apoptosis-induced in vitro anticancer activity of methanolic extract of leaves and rhizomes of Curcuma amada Roxb. against breast cancer cells. Int J Green Pharm (IJGP). 2016;10(2):98–103. https://doi.org/10.22377/ijgp.v10i2.648.

106.

Uchendu IK, Agu CE. Anti-nephrotoxic and antihyperlipidaemic potentials of aqueous extracts of turmeric (Curcuma longa) in hypercholesterolaemic albino rat. Pharmacologyonline. 2018;3:1–11.

107.

Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances. Phytother Res. 2018;32(6):985–95.PubMedCrossRef

108.

Siviero A, Gallo E, Maggini V, Gori L, Mugelli A, Firenzuoli F, Vannacci A. Curcumin, a golden spice with a low bioavailability. J Herb Med. 2015;5(2):57–70.CrossRef

109.

Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: Problems and promises. Mol Pharma. 2007;4(6):807–18.CrossRef

110.

Lu PS, Inbaraj BS, Chen BH. Determination of oral bioavailability of curcuminoid dispersions and nanoemulsions prepared from Curcuma longa Linnaeus. J Sci Food Agric. 2018;98(1):51–63.PubMedCrossRef

111.

Yang K-Y, Lin L-C, Tseng T-Y, Wang S-C, Tsai T-H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC–MS/MS. J Chromatogr B. 2007;853(1–2):183–9.CrossRef

112.

Butnariu M, Quispe C, Sharifi-Rad J, Pons-Fuster E, Lopez-Jornet P, Zam W, Das T, Dey A, Kumar M, Pentea M. Naturally-occurring bioactives in oral cancer: Preclinical and clinical studies, bottlenecks and future directions. Front Biosci-Scholar. 2022;14(3):24.CrossRef

113.

Tietel Z, Butnariu M. Biosynthesis, purification, characterization and uses of natural compounds in plants. Front Plant Sci. 14:1162676. https://doi.org/10.3389/fpls.2023.1162676.

114.

Bahrami A, Montecucco F, Carbone F, Sahebkar A. Effects of curcumin on aging: molecular mechanisms and experimental evidence. BioMed Res Int. 2021;2021:1–13. https://doi.org/10.1155/2021/8972074.CrossRef

115.

Bielak-Zmijewska A, Grabowska W, Ciolko A, Bojko A, Mosieniak G, Bijoch Ł, Sikora E. The role of curcumin in the modulation of ageing. Int J Mol Sci. 2019;20(5):1239.PubMedPubMedCentralCrossRef

116.

Butnariu M, Quispe C, Koirala N, Khadka S, Salgado-Castillo CM, Akram M, et al. Bioactive effects of curcumin in human immunodeficiency virus infection along with the most effective isolation techniques and type of nanoformulations. Int J Nanomed. 2022:3619–32. https://doi.org/10.2147/IJN.S364501.

117.

Afzal A, Oriqat G, Akram Khan M, Jose J, Afzal M. Chemistry and biochemistry of terpenoids from Curcuma and related species. J Biol Act Prod Nat. 2013;3(1):1–55.

118.

Jamwal R. Bioavailable curcumin formulations: A review of pharmacokinetic studies in healthy volunteers. J Integr Med. 2018;16(6):367–74.PubMedCrossRef

119.

Risacher SL, Saykin AJ. Neuroimaging in aging and neurologic diseases. Handb Clin Neurol. 2019;167:191–227.PubMedPubMedCentralCrossRef

Title: Genus Curcuma: chemical and ethnopharmacological role in aging process
Authors: Esraa A. Elhawary
Ashaimaa Y. Moussa
Abdel Nasser B. Singab
Publication date: 01-12-2024
Publisher: BioMed Central
Published in: BMC Complementary Medicine and Therapies / Issue 1/2024
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-023-04317-w

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Genus Curcuma: chemical and ethnopharmacological role in aging process

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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