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Open Access 01-12-2022 | General Anesthesia | Case report

General anesthesia with remimazolam for a pediatric patient with MELAS and recurrent epilepsy: a case report

Authors: Yusuke Yamadori, Yuki Yamagami, Yukihisa Matsumoto, Mari Koizumi, Akiyo Nakamura, Daiskuke Mizuta, Kyoko Yasuda, Gotaro Shirakami

Published in: JA Clinical Reports | Issue 1/2022

Abstract

Background

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a mitochondrial disease. We report here the safe use of remimazolam in a pediatric MELAS patient.

Case presentation

A 10-year-old girl (118 cm, 16 kg) was scheduled for an open gastrostomy to improve nutrition and epileptic seizure control. We induced and maintained general anesthesia with remimazolam, remifentanil, fentanyl, and rocuronium. We also performed a bilateral subcostal transversus abdominis plane block before the surgery. The surgery finished uneventfully. After we discontinued remimazolam administration, the patient woke up immediately but calmly without flumazenil. Epileptic seizures did not occur during intra- and early post-operative periods.

Conclusion

Remimazolam enabled us to provide a pediatric MELAS patient with general anesthesia without causing delayed emergence or epileptic seizures.

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Title: General anesthesia with remimazolam for a pediatric patient with MELAS and recurrent epilepsy: a case report
Authors: Yusuke Yamadori
Yuki Yamagami
Yukihisa Matsumoto
Mari Koizumi
Akiyo Nakamura
Daiskuke Mizuta
Kyoko Yasuda
Gotaro Shirakami
Publication date: 01-12-2022
Publisher: Springer Berlin Heidelberg
Keywords: General Anesthesia
Epileptic Seizure
Flumazenil
Gastrostomy
Epilepsy
Rocuronium
Remifentanil
Anesthetics
Anesthetics
Propofol
Midazolam
Fentanyl
Acidosis
Benzodiazepine
Malignant Hyperthermia
Malignant Hyperthermia
Published in: JA Clinical Reports / Issue 1/2022
Electronic ISSN: 2363-9024
DOI: https://doi.org/10.1186/s40981-022-00564-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

General anesthesia with remimazolam for a pediatric patient with MELAS and recurrent epilepsy: a case report

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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