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Cancer Cell International
Published in: Cancer Cell International 1/2024

Open Access 01-12-2024 | Gastric Cancer | Review

Clinical applications and perspectives of circulating tumor DNA in gastric cancer

Authors: Jing-Han Li, Dan-Ying Zhang, Ji-Min Zhu, Ling Dong

Published in: Cancer Cell International | Issue 1/2024

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Abstract

Gastric cancer remains a leading cause of cancer-related death worldwide, largely due to inadequate screening methods, late diagnosis, and limited treatment options. Liquid biopsy has emerged as a promising non-invasive approach for cancer screening and prognosis by detecting circulating tumor components like circulating tumor DNA (ctDNA) in the blood. Numerous gastric cancer-specific ctDNA biomarkers have now been identified. CtDNA analysis provides insight into genetic and epigenetic alterations in tumors, holding promise for predicting treatment response and prognosis in gastric cancer patients. This review summarizes current research on ctDNA biology and detection technologies, while highlighting clinical applications of ctDNA for gastric cancer diagnosis, prognosis, and guiding treatment decisions. Current challenges and future perspectives for ctDNA analysis are also discussed.
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Metadata
Title
Clinical applications and perspectives of circulating tumor DNA in gastric cancer
Authors
Jing-Han Li
Dan-Ying Zhang
Ji-Min Zhu
Ling Dong
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2024
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-024-03209-4

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