Published in:
Open Access
01-12-2021 | Gastrectomy | Research article
Comparison of clinicopathological features and long-term prognosis between mixed predominantly differentiated-type and pure differentiated-type early gastric cancer
Authors:
Yutaka Okagawa, Tetsuya Sumiyoshi, Hitoshi Kondo, Yusuke Tomita, Takeshi Uozumi, Reiichi Iida, Hiroya Sakano, Kaho Tokuchi, Takashi Jin, Masahiro Yoshida, Akira Sakurada, Ryoji Fujii, Takeyoshi Minagawa, Kohtaro Morita, Kei Yane, Hideyuki Ihara, Michiaki Hirayama, Yumiko Oyamada, Shunichi Okushiba
Published in:
BMC Cancer
|
Issue 1/2021
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Abstract
Background
Recent studies have shown that mixed predominantly differentiated-type (MD) early gastric cancer (EGC) might have more malignant potential than pure differentiated-type (PD) EGC. However, no study has analyzed all differentiated-type EGC cases treated endoscopically and surgically. This study aimed to compare the differences in clinicopathological features and long-term prognosis between MD- and PD-EGC.
Methods
We evaluated all patients with differentiated-type EGCs who were treated endoscopically and surgically in our hospital between January 2010 and October 2014. The clinicopathological features and long-term prognosis of MD-EGC were compared with those of PD-EGC.
Results
A total of 459 patients with 459 lesions were evaluated in this study; of them, 409 (89.1%) and 50 (10.9%) were classified into the PD and MD groups, respectively. Submucosal invasion was found in 96 (23.5%) patients of the PD group and in 33 (66.0%) patients of the MD group (p < 0.01). The rates of positive lymphatic and vascular invasion and ulceration were significantly higher in the MD group than in the PD group (p < 0.01). The proportion of patients with lymph node metastasis was also significantly higher in the MD group than in the PD group (5 (10%) vs 6 (1.5%), p < 0.01). The 5-year overall and EGC-specific survival rates in the PD group were 88.3 and 99.5%, respectively, while they were 94.0 and 98.0% in the MD group, respectively.
Conclusions
MD-EGC has more malignant potential than PD-EGC. However, the long-term prognosis of MD-EGC is good and is not significantly different from that of PD-EGC when treated appropriately.