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01-12-2021 | Hepatitis B | Research article

Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study

Authors: Tong Liu, Wenqiang Li, Youcheng Zhang, Sarah Tan Siyin, Qi Zhang, Mengmeng Song, Kangping Zhang, Siqing Liu, Hanping Shi

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

Previous studies have observed a close association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) as well as extrahepatic cancers. However, research concerning the effect of HBV infection on the risk of colorectal cancer (CRC) is rare and inconsistent. This study aims to determine the relationship between HBV infection and new-onset CRC.

Methods

We prospectively examined the relationship between HBV infection and new-onset CRC among 93,390 participants from Kailuan Cohort study. Cox proportional hazards regression models, subgroup analyses and competing risk analyses were used to evaluate the association between HBV infection and the risk of new-onset CRC.

Results

During a median follow-up of 11.28 years, 448 incident CRC cases were identified. The adjusted HR (95%confidence interval (CI)) for the association of HBsAg Seropositive with CRC was 1.85(1.15 ~ 2.96) in the Cox regression. Subgroup analyses showed that the HBsAg seropositive group was associated with increased risk of new-onset CRC among male, middle-aged, normal weight, smokers and non-drinker participants, respectively. A positive association of HBV infection with the risk of CRC was observed in the adjusted sub-distribution proportional hazards (SD) models (HR_SD = 1.77, 95% CI:1.11–2.84) and cause-specific hazards (CS) models (HR_CS = 1.79, 95% CI: 1.13–2.91).

Conclusions

Our results have found a significant association between HBV infection and the risk of incident CRC among Chinese participants.

Trial registration

Kailuan study, ChiCTR–TNRC–11001489. Registered 24 August 2011 - Retrospectively registered, http:// http://www.chictr.org.cn/showprojen.aspx?proj=8050

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Title: Associations between hepatitis B virus infection and risk of colorectal Cancer: a population-based prospective study
Authors: Tong Liu
Wenqiang Li
Youcheng Zhang
Sarah Tan Siyin
Qi Zhang
Mengmeng Song
Kangping Zhang
Siqing Liu
Hanping Shi
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Hepatitis B
Colorectal Cancer
Colorectal Cancer
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08846-w

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Abstract

Background

Methods

Results

Conclusions

Trial registration

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