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CardioVascular and Interventional Radiology
Published in: CardioVascular and Interventional Radiology 9/2016

01-09-2016 | Case Report

Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia

Authors: Majid Maybody, Ravinder K. Grewal, John H. Healey, Cristina R. Antonescu, Louise Fanchon, Sinchun Hwang, Jorge A. Carrasquillo, Assen Kirov, Azeez Farooki

Published in: CardioVascular and Interventional Radiology | Issue 9/2016

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Abstract

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by small benign tumors of mesenchymal origin also known as phosphaturic mesenchymal tumors mixed connective tissue variant. Excellent prognosis is expected with eradication of the culprit tumor. These small tumors are notoriously difficult to localize with conventional imaging studies; this often leads to an extensive work up and prolonged morbidity. We report a patient with clinical diagnosis of TIO whose culprit tumor was localized with Ga-68 DOTATOC PET/CT and MRI. Biopsy and cryoablation were performed under Ga-68 DOTATOC PET/CT guidance. Autoradiography of the biopsy specimen was performed and showed in situ correlation between Ga-68 DOTATOC uptake and histopathology with millimeter resolution.
Literature
1.
Hautmann AH, Hautmann MG, Kölbl O, Herr W, Fleck M. Tumor-induced osteomalacia: an up-to-date review. Curr Rheumatol Rep. 2015;17(6):1–6.CrossRef
2.
Houang M, Clarkson A, Sioson L, Elston MS, Clifton-Bligh RJ, Dray M, Ranchere-Vince D, Decouvelaere AV, de la Fouchardiere A, Gill AJ. Phosphaturic mesenchymal tumors show positive staining for somatostatin receptor 2A (SSTR2A). Hum Pathol. 2013;44(12):2711–8.CrossRefPubMed
3.
Agrawal K, Bhadada S, Mittal BR, Shukla J, Sood A, Bhattacharya A, Bhansali A. Comparison of 18F-FDG and 68Ga DOTATATE PET/CT in localization of tumor causing oncogenic osteomalacia. Clin Nuclear Med. 2015;40(1):e6–10.CrossRef
4.
Ryan ER, Thornton R, Sofocleous CT, Erinjeri JP, Hsu M, Quinn B, Dauer LT, Solomon SB. PET/CT-guided interventions: personnel radiation dose. Cardiovasc Interv Radiol. 2013;36(4):1063–7.CrossRef
5.
Williamson MJ, Dauer LT. Activity thresholds for patient instruction and release for positron emission tomography radionuclides. Health Phys. 2014;106(3):341–52.CrossRefPubMed
6.
Ryan ER, Sofocleous CT, Schöder H, et al. Split-dose technique for FDG PET/CT-guided percutaneous ablation: a method to facilitate lesion targeting and to provide immediate assessment of treatment effectiveness. Radiology. 2013;268(1):288–95.CrossRefPubMedPubMedCentral
7.
Hesse E, Rosenthal H, Bastian L. Radiofrequency ablation of a tumor causing oncogenic osteomalacia. N Engl J Med. 2007;357(4):422–4.CrossRefPubMed
8.
Tutton S, Olson E, King D, Shaker JL. Successful treatment of tumor-induced osteomalacia with CT-guided percutaneous ethanol and cryoablation. J Clin Endocrinol Metab. 2012;97(10):3421–5.CrossRefPubMed
9.
Weber MA, Sprengel SD, Omlor GW, Lehner B, Wiedenhöfer B, Kauczor HU, Rehnitz C. Clinical long-term outcome, technical success, and cost analysis of radiofrequency ablation for the treatment of osteoblastomas and spinal osteoid osteomas in comparison to open surgical resection. Skelet Radiol. 2015;44(7):981–93.CrossRef
10.
Fanchon LM, Dogan S, Moreira AL, Carlin SA, Schmidtlein CR, Yorke E, Apte AP, Burger IA, Durack JC, Erinjeri JP, Maybody M. Feasibility of in situ, high-resolution correlation of tracer uptake with histopathology by quantitative autoradiography of biopsy specimens obtained under 18F-FDG PET/CT guidance. J Nucl Med. 2015;56(4):538–44.CrossRefPubMedPubMedCentral
Metadata
Title
Ga-68 DOTATOC PET/CT-Guided Biopsy and Cryoablation with Autoradiography of Biopsy Specimen for Treatment of Tumor-Induced Osteomalacia
Authors
Majid Maybody
Ravinder K. Grewal
John H. Healey
Cristina R. Antonescu
Louise Fanchon
Sinchun Hwang
Jorge A. Carrasquillo
Assen Kirov
Azeez Farooki
Publication date
01-09-2016
Publisher
Springer US
Published in
CardioVascular and Interventional Radiology / Issue 9/2016
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI
https://doi.org/10.1007/s00270-016-1350-1

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