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Neurological Sciences

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01-08-2019 | Frontotemporal Dementia | Original Article

Regional cerebral blood flow correlates eating abnormalities in frontotemporal dementia

Authors: Zhi Zhou, Xudong Li, Yi Jin, Yumin Zheng, Shuhong Jia, Jinsong Jiao, Xiaoyun Zheng

Published in: Neurological Sciences | Issue 8/2019

Abstract

Background

Eating abnormalities are one of the core symptoms of frontotemporal dementia (FTD), especially for behavioral variant FTD (bvFTD), and semantic variant primary progressive aphasia (svPPA).

Methods

A group of FTD patients (43 bvFTD, 29 svPPA) underwent single-photon emission CT (SPECT) to measure the region cerebral blood flow (rCBF). The Cambridge Behavioral Inventory (CBI) was used to measure the eating abnormalities. A whole-brain voxel-based correlation between eating abnormalities and rCBF was investigated.

Results

In bvFTD, the sweet preference was correlated with decreased rCBF in the bilateral gyrus rectus and temporal pole, and eating the same food was correlated with the left ventral anterior cingulate cortex. In svPPA, decreased rCBF in the left inferior temporal gyrus was correlated with eating the same food.

Conclusions

These findings showed that either different symptoms in the same subtype or the same symptom in different subtypes of FTD may be correlated with different regions, indicating different neural mechanisms behind them.

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Title: Regional cerebral blood flow correlates eating abnormalities in frontotemporal dementia
Authors: Zhi Zhou
Xudong Li
Yi Jin
Yumin Zheng
Shuhong Jia
Jinsong Jiao
Xiaoyun Zheng
Publication date: 01-08-2019
Publisher: Springer International Publishing
Keywords: Frontotemporal Dementia
Frontotemporal Dementia
Aphasia
Published in: Neurological Sciences / Issue 8/2019
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-019-03910-7

At a glance: The STEP trials

Springer Medicine

Regional cerebral blood flow correlates eating abnormalities in frontotemporal dementia

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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