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Published in: BMC Infectious Diseases 1/2020

Open Access 01-12-2020 | Francisella Tularensis | Case report

Francisella tularensis as the cause of protracted fever

Authors: Lukas Antonitsch, Gerhard Weidinger, Gerold Stanek, Mateusz Markowicz

Published in: BMC Infectious Diseases | Issue 1/2020

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Abstract

Background

Tularemia, a re-emerging, potential life threatening infectious disease, can present itself with nonspecific clinical symptoms including fever, chills and malaise. Taking a detailed history of exposure and a highly raised index of clinical suspicion are necessary to take the appropriate diagnostic and therapeutic steps in this setting. Here, a case report of typhoid tularaemia is presented.

Case presentation

A 53-year old male forester and farmer with protracted fever, abdominal pain, diarrhoea and loss of weight, who experienced productive cough and a pulmonary infiltrate later in the course of disease, was admitted for further investigation. Tularaemia was suspected only owing to history and confirmed by serologic testing more than three weeks after the beginning of the symptoms. The initial antibiotic therapy with ceftriaxone/doxycycline was switched to ciprofloxacin, resulting in the resolution of fever and symptoms.

Conclusion

Tularaemia has to be considered as a differential diagnosis in febrile patients, even more in cases with protracted fever. Since tularaemia is expanding geographically, involving more animal hosts and causing larger outbreaks, clinicians have to be aware of this potentially fatal disease.
Literature
1.
go back to reference Deutz A, et al. Seroepidemiological studies of zoonotic infections in hunters in southeastern Austria--prevalences, risk factors, and preventive methods. Berliner und Munchener tierarztliche Wochenschrift. 2003;116(7–8):306–11.PubMed Deutz A, et al. Seroepidemiological studies of zoonotic infections in hunters in southeastern Austria--prevalences, risk factors, and preventive methods. Berliner und Munchener tierarztliche Wochenschrift. 2003;116(7–8):306–11.PubMed
2.
go back to reference Lang S, Kleines M. Two at one blow: reemergence of tularemia in Upper Austria. New Microbiol. 2012;35(3):349–52.PubMed Lang S, Kleines M. Two at one blow: reemergence of tularemia in Upper Austria. New Microbiol. 2012;35(3):349–52.PubMed
3.
go back to reference Schroll A, et al. Newly emerging ulceroglandular tularaemia in Western Austria. Ticks Tick Borne Dis. 2018;9(5):1331–3.CrossRef Schroll A, et al. Newly emerging ulceroglandular tularaemia in Western Austria. Ticks Tick Borne Dis. 2018;9(5):1331–3.CrossRef
4.
go back to reference Faber M, et al. Tularemia in Germany—A Re-emerging Zoonosis. Front Cell Infect Microbiol. 2018;8:40.CrossRef Faber M, et al. Tularemia in Germany—A Re-emerging Zoonosis. Front Cell Infect Microbiol. 2018;8:40.CrossRef
5.
go back to reference Frischknecht M, et al. Tularemia: an experience of 13 cases including a rare myocarditis in a referral center in eastern Switzerland (Central Europe) and a review of the literature. Infection. 2019;47:1–13. Frischknecht M, et al. Tularemia: an experience of 13 cases including a rare myocarditis in a referral center in eastern Switzerland (Central Europe) and a review of the literature. Infection. 2019;47:1–13.
6.
go back to reference Hauri AM, et al. Investigating an airborne tularemia outbreak, Germany. Emerg Infect Dis. 2010;16(2):238.CrossRef Hauri AM, et al. Investigating an airborne tularemia outbreak, Germany. Emerg Infect Dis. 2010;16(2):238.CrossRef
7.
go back to reference Larssen KW, et al. Outbreak of tularaemia in Central Norway, January to march 2011. Eurosurveillance. 2011;16(13):2–4. Larssen KW, et al. Outbreak of tularaemia in Central Norway, January to march 2011. Eurosurveillance. 2011;16(13):2–4.
8.
go back to reference World Health Organization. WHO guidelines on tularaemia: epidemic and pandemic alert and response. France: World Health Organization; 2007. ISBN 978 92 4 154737 6. World Health Organization. WHO guidelines on tularaemia: epidemic and pandemic alert and response. France: World Health Organization; 2007. ISBN 978 92 4 154737 6.
9.
go back to reference Yon L, et al. Recent changes in infectious diseases in European wildlife. J Wildl Dis. 2019;55(1):3–43.CrossRef Yon L, et al. Recent changes in infectious diseases in European wildlife. J Wildl Dis. 2019;55(1):3–43.CrossRef
Metadata
Title
Francisella tularensis as the cause of protracted fever
Authors
Lukas Antonitsch
Gerhard Weidinger
Gerold Stanek
Mateusz Markowicz
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2020
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-020-05051-1

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