Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Cancer Causes & Control
Published in: Cancer Causes & Control 3/2015

01-03-2015 | Original Paper

Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis

Authors: Min Gao, Kai Sun, Mujie Guo, Hang Gao, Kun Liu, Cuicui Yang, Sheng Li, Ning Liu

Published in: Cancer Causes & Control | Issue 3/2015

Login to get access

Abstract

Purpose

To investigate the association between fish consumption and n-3 polyunsaturated fatty acids (n-3 PUFA) and the risk of hepatocellular carcinoma (HCC).

Methods

We identified eligible studies in MEDLINE and EMBASE up to July 2014 and the reference lists of original studies and review articles on this topic. Summary relative risks (SRR) with their 95 % confidence intervals (CI) were calculated with a random effects model.

Results

Eleven studies (three cohort studies, seven retrospective case–control studies, and one nested case–control study) met eligibility criteria. Ten articles investigated fish consumption, two articles investigated n-3 PUFA, and two articles investigated alpha-linolenic acid (ALA). The current data suggest that fish consumption was associated with 35 % reduction in HCC risk (highest vs. lowest category SRRs = 0.65, 95 % CI 0.51–0.79; test for heterogeneity p = 0.057, I 2 = 44.1 %). n-3 PUFA was associated with 51 % reduction in HCC risk (highest vs. lowest category SRRs = 0.49, 95 % CI 0.19–0.79). However, no significant inverse association was found in ALA (SRRs = 0.70, 95 % CI 0.30–1.10).

Conclusion

Our meta-analysis of observational studies provides evidence that fish consumption and n-3 PUFA has inverse association with the risk of HCC.
Literature
1.
2.
Beasley RP (1988) Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61(10):1942–1956CrossRefPubMed
3.
Shiratori Y, Shiina S, Imamura M, Kato N, Kanai F, Okudaira T, Teratani T, Tohgo G, Toda N, Ohashi M, Et A (1995) Characteristic difference of hepatocellular carcinoma between hepatitis B- and C-viral infection in Japan. Hepatology 22(4 Pt 1):1027–1033CrossRefPubMed
4.
5.
6.
7.
Montella M, Polesel J, La Vecchia C, Dal Maso L, Crispo A, Crovatto M, Casarin P, Izzo F, Tommasi LG, Talamini R, Franceschi S (2007) Coffee and tea consumption and risk of hepatocellular carcinoma in Italy. Int J Cancer 120(7):1555–1559. doi:10.​1002/​ijc.​22509 CrossRefPubMed
8.
9.
Fedirko V, Trichopolou A, Bamia C, Duarte-Salles T, Trepo E, Aleksandrova K, Nothlings U, Lukanova A, Lagiou P, Boffetta P, Trichopoulos D, Katzke VA, Overvad K, Tjonneland A, Hansen L, Boutron-Ruault MC, Fagherazzi G, Bastide N, Panico S, Grioni S, Vineis P, Palli D, Tumino R, Bueno-de-Mesquita HB, Peeters PH, Skeie G, Engeset D, Parr CL, Jakszyn P, Sanchez MJ, Barricarte A, Amiano P, Chirlaque M, Quiros JR, Sund M, Werner M, Sonestedt E, Ericson U, Key TJ, Khaw KT, Ferrari P, Romieu I, Riboli E, Jenab M (2013) Consumption of fish and meats and risk of hepatocellular carcinoma: the European Prospective Investigation into Cancer and Nutrition (EPIC). Ann Oncol 24(8):2166–2173. doi:10.​1093/​annonc/​mdt168 CrossRefPubMedCentralPubMed
10.
Bettinger D, Schultheiss M, Hennecke N, Panther E, Knuppel E, Blum HE, Thimme R, Spangenberg HC (2013) Selenium levels in patients with hepatitis C virus-related chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma: a pilot study. Hepatology 57(6):2543–2544. doi:10.​1002/​hep.​26142 CrossRefPubMed
11.
Fedirko V, Duarte-Salles T, Bamia C, Trichopoulou A, Aleksandrova K, Trichopoulos D, Trepo E, Tjonneland A, Olsen A, Overvad K, Boutron-Ruault MC, Clavel-Chapelon F, Kvaskoff M, Kuhn T, Lukanova A, Boeing H, Buijsse B, Klinaki E, Tsimakidi C, Naccarati A, Tagliabue G, Panico S, Tumino R, Palli D, Bueno-de-Mesquita HB, Siersema PD, Peters PH, Lund E, Brustad M, Standahl OK, Weiderpass VE, Zamora R, Sanchez MJ, Ardanaz E, Amiano P, Navarro C, Quiros JR, Werner M, Sund M, Lindkvist B, Malm J, Travis RC, Khaw KT, Stepien M, Scalbert A, Romieu I, Lagiou P, Riboli E, Jenab M (2014) Pre-diagnostic circulating vitamin D levels and risk of hepatocellular carcinoma in European populations: a nested case–control study. Hepatology. doi:10.​1002/​hep.​27079 PubMedCentral
12.
Fernandez E, Chatenoud L, La Vecchia C, Negri E, Franceschi S (1999) Fish consumption and cancer risk. Am J Clin Nutr 70(1):85–90PubMed
13.
Rose DP, Connolly JM (1999) Omega-3 fatty acids as cancer chemopreventive agents. Pharmacol Ther 83(3):217–244CrossRefPubMed
14.
15.
16.
17.
Zheng JS, Hu XJ, Zhao YM, Yang J, Li D (2013) Intake of fish and marine n-3 polyunsaturated fatty acids and risk of breast cancer: meta-analysis of data from 21 independent prospective cohort studies. BMJ 346:f3706CrossRefPubMed
18.
19.
20.
Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB (2000) Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis of observational studies in epidemiology (MOOSE) group. JAMA 283(15):2008–2012CrossRefPubMed
21.
La Vecchia C, Negri E, Decarli A, D’Avanzo B, Franceschi S (1988) Risk factors for hepatocellular carcinoma in northern Italy. Int J Cancer 42(6):872–876CrossRefPubMed
22.
Kurozawa Y, Ogimoto I, Shibata A, Nose T, Yoshimura T, Suzuki H, Sakata R, Fujita Y, Ichikawa S, Iwai N, Fukuda K, Tamakoshi A (2004) Dietary habits and risk of death due to hepatocellular carcinoma in a large scale cohort study in Japan. Univariate analysis of JACC study data. Kurume Med J 51(2):141–149CrossRefPubMed
23.
Greenland S (1987) Quantitative methods in the review of epidemiologic literature. Epidemiol Rev 9:1–30PubMed
24.
25.
26.
Sterne JA, Egger M (2001) Funnel plots for detecting bias in meta-analysis: guidelines on choice of axis. J Clin Epidemiol 54(10):1046–1055CrossRefPubMed
27.
Duval S, Tweedie R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56(2):455–463CrossRefPubMed
28.
Lu SN, Lin TM, Chen CJ, Chen JS, Liaw YF, Chang WY, Hsu ST (1988) A case–control study of primary hepatocellular carcinoma in Taiwan. Cancer 62(9):2051–2055CrossRefPubMed
29.
Qiu XQ, Tan SK, Yu HP, Zeng XY, Li LQ, Hu L (2008) Synergistic effect of HBV infection, alcohol and raw fish consumption on oncogenisis of primary hepatic carcinoma. Zhonghua Zhong Liu Za Zhi 30(2):113–115PubMed
30.
Tan SK, Qiu XQ, Yu HP, Zeng XY, Xiao ZM, Hu L (2008) Etiologic fraction and interaction of risk factors for primary hepatic carcinoma in Guangxi, China. Zhonghua Yu Fang Yi Xue Za Zhi 42(3):169–172PubMed
31.
32.
33.
34.
35.
Kanazir M, Boricic I, Delic D, Tepavcevic DK, Knezevic A, Jovanovic T, Pekmezovic T (2010) Risk factors for hepatocellular carcinoma: a case–control study in Belgrade (Serbia). Tumori 96(6):911–917PubMed
36.
Polesel J, Talamini R, Montella M, Maso LD, Crovatto M, Parpinel M, Izzo F, Tommasi LG, Serraino D, La Vecchia C, Franceschi S (2007) Nutrients intake and the risk of hepatocellular carcinoma in Italy. Eur J Cancer 43(16):2381–2387. doi:10.​1016/​j.​ejca.​2007.​07.​012 CrossRefPubMed
37.
Talamini R, Polesel J, Montella M, Dal Maso L, Crispo A, Tommasi LG, Izzo F, Crovatto M, La Vecchia C, Franceschi S (2006) Food groups and risk of hepatocellular carcinoma: a multicenter case–control study in Italy. Int J Cancer 119(12):2916–2921. doi:10.​1002/​ijc.​22267 CrossRefPubMed
38.
Yu SZ, Huang XE, Koide T, Cheng G, Chen GC, Harada K, Ueno Y, Sueoka E, Oda H, Tashiro F, Mizokami M, Ohno T, Xiang J, Tokudome S (2002) Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. Jpn J Cancer Res 93(12):1287–1292CrossRefPubMed
39.
Metwally NS, Kholeif TE, Ghanem KZ, Farrag AR, Ammar NM, Abdel-Hamid AH (2011) The protective effects of fish oil and artichoke on hepatocellular carcinoma in rats. Eur Rev Med Pharmacol Sci 15(12):1429–1444PubMed
40.
Larsson SC, Kumlin M, Ingelman-Sundberg M, Wolk A (2004) Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. Am J Clin Nutr 79(6):935–945PubMed
41.
Sanzo JM, Dorronsoro M, Amiano P, Amurrio A, Aguinagalde FX, Azpiri MA (2001) Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain. Public Health Nutr 4(5):981–988CrossRefPubMed
42.
Sjodin A, Hagmar L, Klasson-Wehler E, Bjork J, Bergman A (2000) Influence of the consumption of fatty baltic sea fish on plasma levels of halogenated environmental contaminants in Latvian and Swedish men. Environ Health Perspect 108(11):1035–1041CrossRefPubMedCentralPubMed
43.
Rojas E, Herrera LA, Poirier LA, Ostrosky-Wegman P (1999) Are metals dietary carcinogens? Mutat Res 443(1–2):157–181CrossRefPubMed
44.
Williams CD, Whitley BM, Hoyo C, Grant DJ, Iraggi JD, Newman KA, Gerber L, Taylor LA, McKeever MG, Freedland SJ (2011) A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer. Nutr Res 31(1):1–8. doi:10.​1016/​j.​nutres.​2011.​01.​002 CrossRefPubMed
45.
46.
Metadata
Title
Fish consumption and n-3 polyunsaturated fatty acids, and risk of hepatocellular carcinoma: systematic review and meta-analysis
Authors
Min Gao
Kai Sun
Mujie Guo
Hang Gao
Kun Liu
Cuicui Yang
Sheng Li
Ning Liu
Publication date
01-03-2015
Publisher
Springer International Publishing
Published in
Cancer Causes & Control / Issue 3/2015
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI
https://doi.org/10.1007/s10552-014-0512-1

Other articles of this Issue 3/2015

Cancer Causes & Control 3/2015 Go to the issue

Original paper

Association between high-sensitivity C-reactive protein (hsCRP) and change in mammographic density over time in the SWAN mammographic density subcohort

Original Paper

Classification tree analysis to examine influences on colorectal cancer screening

Original paper

Blood lipids and colorectal polyps: testing an etiologic hypothesis using phenotypic measurements and Mendelian randomization

Original paper

Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers’ Cohort (MTC, ESMaestras)

Original Paper

Potentially preventable premature lung cancer deaths in the USA if overall population rates were reduced to those of educated whites in lower-risk states

Brief report

Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits