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01-03-2015 | Original paper

Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers’ Cohort (MTC, ESMaestras)

Authors: Sabina Rinaldi, Carine Biessy, Maria de la Luz Hernandez, Martin Lajous, Eduardo Ortiz-Panozo, Elsa Yunes, Ruy Lopez-Ridaura, Gabriela Torres-Mejia, Isabelle Romieu

Published in: Cancer Causes & Control | Issue 3/2015

Abstract

Purpose

Obesity is a major risk factor for several cancers, including female cancers. Endogenous hormones and inflammatory factors may mediate the association between anthropometric measures and cancer risk, although these associations have been studied mainly in Caucasians. The aim of the current study was to explore the association of circulating hormones, adipokines, and inflammatory factors with obesity and overweight in premenopausal Mexican women.

Methods

We conducted a cross-sectional analysis of 504 premenopausal women from the large Mexican Teachers’ Cohort (MTC, ESMaestras) study to determine the association of insulin-like growth factor I (IGF-I), its major circulating binding protein (IGFBP-3), leptin, adiponectin, C-peptide, and C-reactive protein with comprehensive measures of body size. Biomarkers were measured by immunoassays. Multivariate regression analyses were performed to compare geometric mean biomarker concentrations with measured markers of body size and adiposity.

Results

Mean IGF-I and IGFBP-3 concentrations significantly increased with increasing height and leg length. Concentrations of IGF-I, adiponectin, and the IGF-I/IGFBP-3 ratio strongly decreased with increasing BMI, weight, waist and hip circumferences, waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), while CRP, leptin, C-peptide concentrations, and the leptin/adiponectin ratio strongly increased. Adiponectin and the leptin/adiponectin ratio remained significantly related to measures of central adiposity (waist circumference, WHpR, and WHtR) after adjustment by body mass index.

Conclusions

The results of our study suggest a strong relation between biomarkers and body size in this study population and suggest that different fat depots may have different metabolic properties.

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Title: Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers’ Cohort (MTC, ESMaestras)
Authors: Sabina Rinaldi
Carine Biessy
Maria de la Luz Hernandez
Martin Lajous
Eduardo Ortiz-Panozo
Elsa Yunes
Ruy Lopez-Ridaura
Gabriela Torres-Mejia
Isabelle Romieu
Publication date: 01-03-2015
Publisher: Springer International Publishing
Published in: Cancer Causes & Control / Issue 3/2015
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-015-0527-2

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Abstract

Purpose

Methods

Results

Conclusions

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