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Published in: Cardiovascular Toxicology 1/2011

01-03-2011

Fatal Pulmonary Oedema Following Oxytocin Administration in a Pregnant Woman with Acute Myocardial Infarction

Authors: Orhan Dogdu, Mikail Yarlioglues, Tugrul Inanc, Idris Ardic, Cemil Zencir, Mehmet Gungor Kaya

Published in: Cardiovascular Toxicology | Issue 1/2011

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Abstract

Acute myocardial infarction is a rare event in pregnant patients. Mechanical valves are naturally thrombogenic and require careful anticoagulation. Pregnancy produces a hypercoagulable situation and necessitates close follow-up in pregnant patients with mechanical heart valves. We present a 34-year-old pregnant woman who had mitral and aortic valve prosthesis. She developed resistant pulmonary oedema in the post-partum period after myocardial infarction. Oxytocin was used in this patient to induce midterm labour and prevent post-partum bleeding. Issues surrounding management of pulmonary oedema and use of oxytocin therapy during pregnancy are discussed. We emphasize the need for awareness of this condition and call attention to the risk of pulmonary oedema during labour.
Literature
1.
go back to reference Li, C., Wang, W., Summer, S. N., et al. (2008). Molecular mechanisms of antidiuretic effect of oxytocin. Journal of the American Society of Nephrology, 19, 189–190.CrossRef Li, C., Wang, W., Summer, S. N., et al. (2008). Molecular mechanisms of antidiuretic effect of oxytocin. Journal of the American Society of Nephrology, 19, 189–190.CrossRef
2.
go back to reference Wahal, A. K., Kapoor, V. K., & Venogopal, M. (2003). Pulmonary edema following concomitant administration of oxytocin and vasopressor during LSCS under subarachnoid block. Indian J Anaesth, 47, 302–303. Wahal, A. K., Kapoor, V. K., & Venogopal, M. (2003). Pulmonary edema following concomitant administration of oxytocin and vasopressor during LSCS under subarachnoid block. Indian J Anaesth, 47, 302–303.
3.
go back to reference Ghai, B., Vayjnath, A. M., & Lal, S. (2006). Acute pulmonary edema following oxytocin administration: A life-threatening complication. Journal of the Indian Medical Association, 104, 261–262.PubMed Ghai, B., Vayjnath, A. M., & Lal, S. (2006). Acute pulmonary edema following oxytocin administration: A life-threatening complication. Journal of the Indian Medical Association, 104, 261–262.PubMed
4.
go back to reference Pettman, J. G. (1963). Water intoxication due to oxytocin. New England Journal of Medicine, 268, 481–482.CrossRefPubMed Pettman, J. G. (1963). Water intoxication due to oxytocin. New England Journal of Medicine, 268, 481–482.CrossRefPubMed
5.
go back to reference Elkayam, U., & Bitar, F. (2005). Valvular heart disease and pregnancy: Part II: Prosthetic valves. Journal of the American College of Cardiology, 46, 403–410.CrossRefPubMed Elkayam, U., & Bitar, F. (2005). Valvular heart disease and pregnancy: Part II: Prosthetic valves. Journal of the American College of Cardiology, 46, 403–410.CrossRefPubMed
6.
go back to reference Roth, A., & Elkayam, U. (1996). Acute myocardial infarction associated with pregnancy. Annals of Internal Medicine, 125, 751–762.PubMed Roth, A., & Elkayam, U. (1996). Acute myocardial infarction associated with pregnancy. Annals of Internal Medicine, 125, 751–762.PubMed
7.
go back to reference Mokdad, A. H., Serdula, M. K., Dietz, W. H., et al. (1999). The spread of the obesity epidemic in the United States, 1991–1998. JAMA, 282, 1519–1522.CrossRefPubMed Mokdad, A. H., Serdula, M. K., Dietz, W. H., et al. (1999). The spread of the obesity epidemic in the United States, 1991–1998. JAMA, 282, 1519–1522.CrossRefPubMed
8.
go back to reference Tanis, B. C., van den Bosch, M. A., Kemmeren, J. M., et al. (2001). Oral contraceptives and the risk of myocardial infarction. New England Journal of Medicine, 345, 1787–1793.CrossRefPubMed Tanis, B. C., van den Bosch, M. A., Kemmeren, J. M., et al. (2001). Oral contraceptives and the risk of myocardial infarction. New England Journal of Medicine, 345, 1787–1793.CrossRefPubMed
9.
go back to reference Akita, M., Oka, T., Takamura, T., et al. (2004). Acute myocardial infarction produced by methylergometrine maleate-induced coronary vasospasm. Nippon Naika Gakkai Zasshi, 93, 1442–1444. [in Japanese].PubMed Akita, M., Oka, T., Takamura, T., et al. (2004). Acute myocardial infarction produced by methylergometrine maleate-induced coronary vasospasm. Nippon Naika Gakkai Zasshi, 93, 1442–1444. [in Japanese].PubMed
10.
go back to reference Duran, J. R., 3rd, & Raja, M. L. (2007). Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation induction: A case report. Journal of Reproductive Medicine, 52, 1059–1062.PubMed Duran, J. R., 3rd, & Raja, M. L. (2007). Myocardial infarction in pregnancy associated with clomiphene citrate for ovulation induction: A case report. Journal of Reproductive Medicine, 52, 1059–1062.PubMed
11.
go back to reference Maeder, M., Ammann, P., Angehrn, W., et al. (2005). Idiopathic spontaneous coronary artery dissection: Incidence, diagnosis and treatment. International Journal of Cardiology, 101, 363–369.CrossRefPubMed Maeder, M., Ammann, P., Angehrn, W., et al. (2005). Idiopathic spontaneous coronary artery dissection: Incidence, diagnosis and treatment. International Journal of Cardiology, 101, 363–369.CrossRefPubMed
12.
go back to reference Yilmaz, M., Acıkel, M., Bozkurt, E., et al. (2000). Acute myocardial infarction secondary to coronary embolism in a patient with mitral and aortic valve prosthesis: A case report. Arch Turk Soc Cardiol, 28, 703–705. Yilmaz, M., Acıkel, M., Bozkurt, E., et al. (2000). Acute myocardial infarction secondary to coronary embolism in a patient with mitral and aortic valve prosthesis: A case report. Arch Turk Soc Cardiol, 28, 703–705.
13.
go back to reference Ottman, E. H., & Gall, S. A. (1993). Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus. Obstetrics and Gynecology, 81(Pt 2), 804–805.PubMed Ottman, E. H., & Gall, S. A. (1993). Myocardial infarction in the third trimester of pregnancy secondary to an aortic valve thrombus. Obstetrics and Gynecology, 81(Pt 2), 804–805.PubMed
14.
go back to reference Bonow, R. O., Carabello, B. A., Kanu, C., et al. (2006). ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 114, e84–e231.CrossRefPubMed Bonow, R. O., Carabello, B. A., Kanu, C., et al. (2006). ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation, 114, e84–e231.CrossRefPubMed
15.
go back to reference Quinn, J., Von Klemperer, K., Brooks, R., et al. (2009). Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: A single-center experience. Haematologica, 94(11), 1608–1612.CrossRefPubMed Quinn, J., Von Klemperer, K., Brooks, R., et al. (2009). Use of high intensity adjusted dose low molecular weight heparin in women with mechanical heart valves during pregnancy: A single-center experience. Haematologica, 94(11), 1608–1612.CrossRefPubMed
16.
go back to reference Crowther, M. A., Spitzer, K., Julian, J., et al. (2000). Pharmacokinetic profile of a low-molecular weight (Reviparin) in pregnant patients: A prospective cohort study. Thrombosis Research, 98, 133–138.CrossRefPubMed Crowther, M. A., Spitzer, K., Julian, J., et al. (2000). Pharmacokinetic profile of a low-molecular weight (Reviparin) in pregnant patients: A prospective cohort study. Thrombosis Research, 98, 133–138.CrossRefPubMed
17.
go back to reference Bates, S. M., Greer, I. A., Hirsh, J., et al. (2004). Use of antithrombotic agents during pregnancy: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest, 126(3 Suppl), 627S–644S.CrossRefPubMed Bates, S. M., Greer, I. A., Hirsh, J., et al. (2004). Use of antithrombotic agents during pregnancy: The seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest, 126(3 Suppl), 627S–644S.CrossRefPubMed
18.
go back to reference Roth, A., & Elkayam, U. (2008). Acute myocardial infarction associated with pregnancy. Journal of the American College of Cardiology, 52, 171–180.CrossRefPubMed Roth, A., & Elkayam, U. (2008). Acute myocardial infarction associated with pregnancy. Journal of the American College of Cardiology, 52, 171–180.CrossRefPubMed
19.
go back to reference Haddad, B., Masson, C., Deis, S., et al. (2010). Collége national des gynécologues et obstétriciens; Société française de médecine périnatale; Société française de néonatalogie; Société française de anesthésie et de réanimation. [Criteria of pregnancy termination in women with preeclampsia]. Annales Francaises d’Anesthesie et de Reanimation, 29(4), e59–68. Epub 2010 Mar 27. Review.CrossRefPubMed Haddad, B., Masson, C., Deis, S., et al. (2010). Collége national des gynécologues et obstétriciens; Société française de médecine périnatale; Société française de néonatalogie; Société française de anesthésie et de réanimation. [Criteria of pregnancy termination in women with preeclampsia]. Annales Francaises d’Anesthesie et de Reanimation, 29(4), e59–68. Epub 2010 Mar 27. Review.CrossRefPubMed
20.
go back to reference Philips, C. A., & Kinch, R. A. (1994). Management of the third stage of labor: A survey of practice among Texas obstetricians. Texas Medicine, 90, 44–47. Philips, C. A., & Kinch, R. A. (1994). Management of the third stage of labor: A survey of practice among Texas obstetricians. Texas Medicine, 90, 44–47.
21.
go back to reference Cunningham, F. G., Gant, N. F., & Leveno, K. J., et al. (2001). Chapter 13. Conduct of normal labor and delivery, 21st edi. Williams Obstetrics. Mc Graw Hill (pp. 309–331). Cunningham, F. G., Gant, N. F., & Leveno, K. J., et al. (2001). Chapter 13. Conduct of normal labor and delivery, 21st edi. Williams Obstetrics. Mc Graw Hill (pp. 309–331).
Metadata
Title
Fatal Pulmonary Oedema Following Oxytocin Administration in a Pregnant Woman with Acute Myocardial Infarction
Authors
Orhan Dogdu
Mikail Yarlioglues
Tugrul Inanc
Idris Ardic
Cemil Zencir
Mehmet Gungor Kaya
Publication date
01-03-2011
Publisher
Humana Press Inc
Published in
Cardiovascular Toxicology / Issue 1/2011
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-010-9093-8

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