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Cancer and Metastasis Reviews
Published in: Cancer and Metastasis Reviews 3-4/2011

01-12-2011

Extracellular and intracellular sphingosine-1-phosphate in cancer

Authors: Jessie W. Yester, Etsegenet Tizazu, Kuzhuvelil B. Harikumar, Tomasz Kordula

Published in: Cancer and Metastasis Reviews | Issue 3-4/2011

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Abstract

Sphingosine-1-phosphate (S1P) was first described as a signaling molecule over 20 years ago. Since then, great strides have been made to reveal its vital roles in vastly different cellular and disease processes. Initially, S1P was considered nothing more than the terminal point of sphingolipid metabolism; however, over the past two decades, a large number of reports have helped unveil its full potential as an important regulatory, bioactive sphingolipid metabolite. S1P has a plethora of physiological functions, due in part to its many sites of actions and its different pools, which are both intra- and extracellular. S1P plays pivotal roles in many physiological processes, including the regulation of cell growth, migration, autophagy, angiogenesis, and survival, and thus, not surprisingly, S1P has been linked to cancer. In this review, we will summarize the vast body of knowledge, highlighting the connection between S1P and cancer. We will also suggest new avenues for future research.
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Metadata
Title
Extracellular and intracellular sphingosine-1-phosphate in cancer
Authors
Jessie W. Yester
Etsegenet Tizazu
Kuzhuvelil B. Harikumar
Tomasz Kordula
Publication date
01-12-2011
Publisher
Springer US
Published in
Cancer and Metastasis Reviews / Issue 3-4/2011
Print ISSN: 0167-7659
Electronic ISSN: 1573-7233
DOI
https://doi.org/10.1007/s10555-011-9305-0

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