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01-11-2010 | Breast

Exposure to low-dose radiation and the risk of breast cancer among women with a familial or genetic predisposition: a meta-analysis

Authors: Marijke C. Jansen-van der Weide, Marcel J. W. Greuter, Liesbeth Jansen, Jan C. Oosterwijk, Ruud M. Pijnappel, Geertruida H. de Bock

Published in: European Radiology | Issue 11/2010

Abstract

Background:

Women with familial or genetic aggregation of breast cancer are offered screening outside the population screening programme. However, the possible benefit of mammography screening could be reduced due to the risk of radiation-induced tumours. A systematic search was conducted addressing the question of how low-dose radiation exposure affects breast cancer risk among high-risk women.

Methods:

A systematic search was conducted for articles addressing breast cancer, mammography screening, radiation and high-risk women. Effects of low-dose radiation on breast cancer risk were presented in terms of pooled odds ratios (OR).

Results:

Of 127 articles found, 7 were selected for the meta-analysis. Pooled OR revealed an increased risk of breast cancer among high-risk women due to low-dose radiation exposure (OR = 1.3, 95% CI: 0.9– 1.8). Exposure before age 20 (OR = 2.0, 95% CI: 1.3–3.1) or a mean of ≥5 exposures (OR = 1.8, 95% CI: 1.1–3.0) was significantly associated with a higher radiation-induced breast cancer risk.

Conclusion:

Low-dose radiation increases breast cancer risk among high-risk women. When using low-dose radiation among high-risk women, a careful approach is needed, by means of reducing repeated exposure, avoidance of exposure at a younger age and using non-ionising screening techniques.

Dutch Cancer Registry (2006) Available via IKCnet. http://www.ikcnet.nl. Accessed 28 April 2010

Jemal A, Murray T, Ward E et al (2005) Cancer statistics. CA Cancer J Clin 55:10–30CrossRefPubMed

Loman N, Johannsson O, Kristoffersson U et al (2001) Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. J Nat Cancer Inst 93:1215–1223CrossRefPubMed

Collaborative Group on Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet 358:1389–1399CrossRef

Nathanson KN, Wooster R, Weber BL (2001) Breast cancer genetics: what we know and what we need. Nat Med 7:552–556CrossRefPubMed

Verhoog LC, van den Ouweland AM, Berns E et al (2001) Large regional differences in the frequency of distinct BRCA1/BRCA2 mutations in 517 Dutch breast and/or ovarian cancer families. Eur J Cancer 37:2082–2090CrossRefPubMed

Chen S, Parmigiani G (2007) Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol 25:1329–1333CrossRefPubMed

Cui J, Antoniou AC, Dite GS et al (2001) After BRCA1 and BRCA2—what next? multifactorial segregation analyses of three-generation, population-based Australian families affected by female breast cancer. Am J Hum Genet 68:420–431CrossRefPubMed

Antoniou AC, Pharoah PD, McMullan G et al (2002) A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes. Br J Cancer 86:76–83CrossRefPubMed

10.

de Jong MM, Nolte IM, Te Meerman GJ et al (2002) Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility. J Med Genet 39:225–242CrossRefPubMed

11.

Goode EL, Dunning AM, Kuschel B et al (2002) Effect of germ-line genetic variation on breast cancer survival in a population-based study. Cancer Res 62:3052–3057PubMed

12.

Vahteristo P, Bartkova J, Eerola H et al (2002) A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Am J Hum Genet 71:432–438CrossRefPubMed

13.

de Bock GH, Schutte M, Krol-Warmerdam EMM et al (2004) Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK*1100delC variant. J Med Genet 41:731–735CrossRefPubMed

14.

Shapiro S, Coleman EA, Broeders M et al (1998) Breast cancer screening programmes in 22 countries: current policies, administration and guidelines. international breast cancer screening network (IBSN) and the European network of pilot projects for breast cancer screening. Int J Epidemiol 27:735–742CrossRefPubMed

15.

Kriege M, Brekelmans CT, Boetes C et al (2004) Efficacy of MRI and mammography for breast-cancer screening in women with a familial or genetic predisposition. N Engl J Med 351:427–437CrossRefPubMed

16.

Leach MO, Boggis CR, Dixon AK et al (2005) The MARIBS study group. Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS). Lancet 365:1769–1778CrossRefPubMed

17.

Warner E, Messersmith H, Causer P et al (2008) Systematic review: using magnetic resonance imaging to screen women at high risk for breast cancer. Ann Int Med 148:671–679PubMed

18.

Lee CH, Dershaw DD, Kopans D et al (2010) Breast cancer screening with imaging: recommendations from the Society of breast imaging and the ACR on the use of mammography, breast MRI, breast ultrasound, and other technologies for the detection of clinically occult breast cancer. J Am Coll Radiol 7:18–27CrossRefPubMed

19.

Preston DL, Mattson A, Holmberg E et al (2002) Radiation effects on breast cancer risk: a pooled analysis of eight cohorts. Radiat Res 158:220–235CrossRefPubMed

20.

Ronckers CM, Erdmann CA, Land CE (2005) Radiation and breast cancer: a review of current evidence. Breast Cancer Res 7:21–32CrossRefPubMed

21.

Zoetelief J, Veldkamp WJH, Thijssen MAO, Jansen JTM (2006) Glandularity and mean glandular dose determined for individual women at four regional breast cancer screening units in the Netherlands. Phys Med Biol 51:1807–1817CrossRefPubMed

22.

Wakeford R (2004) The cancer epidemiology of radiation. Oncogene 23:6404–6428CrossRefPubMed

23.

Broeks A, Braaf LM, Huseinovic A et al (2007) Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study. Breast Cancer Res 9:106–114CrossRef

24.

Hill DA, Preston-Martin S, Ross RK, Bernstein L (2002) Medical radiation, family history of cancer, and benign breast disease in relation to breast cancer risk in young women, USA. Cancer Causes Control 13:711–718CrossRefPubMed

25.

Rothfuss A, Schutz P, Bochum S et al (2000) Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res 60:390–394PubMed

26.

Tutt ANJ, Van Oostrom CTM, Ross GM et al (2002) Disruption of BRCA2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation. EMBO Rep 31:255–260CrossRef

27.

Berrington de Gonzalez A, Reeves G (2005) Mammographic screening before age 50 years in the UK: comparison of the radiation risks with the mortality benefits. Br J Cancer 93:590–596CrossRefPubMed

28.

Chakraborty R, Sankaranarayanan K (1995) Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers II. A Mendelian single-locus model of cancer predisposition and radiosensitivity for predicting cancer risks in populations. Radiat Res 143:293–301CrossRefPubMed

29.

Chakraborty R, Sankaranarayanan K (1998) Mutations in the BRCA1 gene: implications of inter-population differences for predicting the risk of radiation-induced breast cancers. Genet Res 72:191–198CrossRefPubMed

30.

Chakraborty R, Little MP, Sankaranarayanan (1998) Cancer predisposition, radiosensitivity and the risk of radiation-induced cancers. IV. prediction of risks in relatives of cancer-predisposed individuals. Radiat Res 149:493–507CrossRefPubMed

31.

Den Otter W, Merchant TE, Beijerink D et al (1993) Exclusion from mammographic screening of women genetically predisposed to breast cancer will probably eliminate mammographically induced breast cancer. Anticancer Res 13:1113–1116

32.

Den Otter W, Merchant TE, Beijerink D et al (1996) Breast cancer induction due to mammographic screening in hereditarily affected women. Anticancer Res 16:3173–3176

33.

Law J, Faulkner K (2001) Cancers detected and induced, and associated risk and benefit, in a breast screening programme. Br J Radiol 74:1121–1127PubMed

34.

Law J, Faulkner K (2002) Concerning the relationship between benefit and radiation risk, and cancers detected and induced, in a breast screening programme. Br J Radiol 75:678–684PubMed

35.

Law J, Faulkner F, Young KC (2007) Risk factors for induction of breast cancer by X-rays and their implications for breast screening. Br J Radiol 80:261–266CrossRefPubMed

36.

Andrieu N, Easton DF, Chang-Claude J et al (2006) Effect of chest X-rays on the risk of breast cancer among BRCA1/2 mutation carriers in the international BRCA1/2 carrier cohort study: a report from the EMBRACE, GENEPSO, GEO-HEBON, and IBCCS Collaborators' Group. J Clin Oncol 24:3361–3366CrossRefPubMed

37.

Bernstein JL, Teraoka SN, John EM et al (2006) The CHEK*1100delC allelic variant and risk of breast cancer: screening results from the breast cancer family registry. Cancer Epidemiol Biomark Prev 15:348–352CrossRef

38.

Goldfrank D, Chuai S, Bernstein JL et al (2006) Effect of mammography on breast cancer risk in women with mutations in BRCA1 or BRCA2. Cancer Epidemiol Biomark Prev 15:2311–2313CrossRef

39.

John EM, Phipps AI, Knight JA et al (2007) Medical radiation and breast cancer risk: findings from the breast cancer family registry. Int J Cancer 121:386–394CrossRefPubMed

40.

Ma H, Hill CK, Bernstein L, Ursin G (2008) Low-dose medical radiation exposure and breast cancer risk in women under age 50 years overall and by estrogen and progesterone receptor status: results from a case-control and case-case comparison. Breast Cancer Res Treat 109:77–90CrossRefPubMed

41.

Narod SA, Lubinski J, Ghadirian P et al (2006) Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Lancet Oncol 7:402–406CrossRefPubMed

42.

Millikan RC, Player JS, Decotret AR et al (2005) Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk. Cancer Epidemiol Biomark Prev 14:2326–2334CrossRef

43.

Wells GA, Shea B, O'Connell J et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm

44.

Schaefer-Prokop C, Neitzel U, Venema HW et al (2008) Digital chest radiography: an update on modern technology, dose containment, and control of image quality. Eur Radiol 18:1818–1830CrossRefPubMed

45.

Vandenbroucke JP, Hofman A (1999) Principles of epidemiology. Reed Business, Amsterdam

46.

Higgins JP, Thompson SG, Deeks JJ et al (2003) Measuring inconsistency in meta-analyses. BMJ 327:557–560CrossRefPubMed

47.

DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188CrossRefPubMed

48.

Land CE, Tokunaga M, Koyama K et al (2003) Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res 160:707–717CrossRefPubMed

49.

Boice JD Jr, Preston D, Davis FG, Monson RR (1991) Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiat Res 125:214–222CrossRefPubMed

50.

Hrubec Z, Boice JD Jr, Monson RR, Rosenstein M (1989) Breast cancer after multiple chest fluorscopies: second follow-up of Massachusetts women with tuberculosis. Cancer Res 49:229–234PubMed

51.

Berrington de Gonzalez A, Ekboom A, Glass A et al (2003) Comparison of documented and recalled histories of exposure to diagnostic X-rays in case-control studies of thyroid cancer. Am J Epidemiol 157:652–663CrossRefPubMed

52.

Pagoda JM, Preston-Martin S (2002) Radiation exposure from diagnostic imaging: agreement between self-report and medical records. Health Phys 83:907–917CrossRef

53.

Preston-Martin S, Bernstein L, Maldonado AA et al (1985) Comparison of information from patient interviews and dental charts. Am J Epidemiol 121:430–439PubMed

54.

Berrington de Gonzalez A, Berg CD, Visvanathan K, Robson M (2009) Estimated risk of radiation-induced breast cancer from mammographic screening for young BRCA mutation carriers. J Natl Cancer Inst 101:205–209CrossRefPubMed

Title: Exposure to low-dose radiation and the risk of breast cancer among women with a familial or genetic predisposition: a meta-analysis
Authors: Marijke C. Jansen-van der Weide
Marcel J. W. Greuter
Liesbeth Jansen
Jan C. Oosterwijk
Ruud M. Pijnappel
Geertruida H. de Bock
Publication date: 01-11-2010
Publisher: Springer-Verlag
Published in: European Radiology / Issue 11/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1839-y

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Exposure to low-dose radiation and the risk of breast cancer among women with a familial or genetic predisposition: a meta-analysis

Abstract

Background:

Methods:

Results:

Conclusion:

Keynote webinar | Spotlight on medication adherence

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Abstract

Background:

Methods:

Results:

Conclusion:

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