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European Radiology
Published in: European Radiology 11/2010

01-11-2010 | Oncology

Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours

Authors: Armanda De Marchi, Elena Maria Brach del Prever, Alessandra Linari, Simona Pozza, Lucia Verga, Ugo Albertini, Marco Forni, Gian Carlo Gino, Alessandro Comandone, Adalberto Maria Brach del Prever, Raimondo Piana, Carlo Faletti, Piedmont Sarcoma Group

Published in: European Radiology | Issue 11/2010

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Abstract

Objective

Percutaneous biopsies are gaining acceptance in the diagnosis of soft-tissue tumours. Sampling in the most representative area is not easy in sarcomas of huge dimension. We hypothesised that ultrasound (US) contrast medium could identify the representative area for focus core-needle biopsy (CNB)

Methods

This is a retrospective cohort series of 115 soft-tissue masses treated from January 2007 to November 2008. Accuracy of US-guided CNB after contrast-enhanced US (CEUS) was determined by comparing the histology of the biopsy with the definitive diagnosis in 105 surgically excised samples (42 benign, 63 malignant) and with the expected outcome in the remaining ten malignant cases not surgically treated. A myxoid component was present in 21 sarcomas (34.4%).

Results

Of samples, 94.8% were adequate for diagnosis with 97.1% sensitivity and 92.5% specificity. Sensitivity and specificity in specific histopathological subgroupings were 100%, and in grading definition they were 100% and 96.8%.

Discussion

US-guided CNB is safe and effective. US contrast medium depicts tumour vascular supply and identifies the representative area(s) for sampling. Sensitivity and specificity are also high in subgrouping and grading, including myxoid types. Discussion about biopsy is part of the essential multidisciplinary strategy for these tumours.
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Metadata
Title
Accuracy of core-needle biopsy after contrast-enhanced ultrasound in soft-tissue tumours
Authors
Armanda De Marchi
Elena Maria Brach del Prever
Alessandra Linari
Simona Pozza
Lucia Verga
Ugo Albertini
Marco Forni
Gian Carlo Gino
Alessandro Comandone
Adalberto Maria Brach del Prever
Raimondo Piana
Carlo Faletti
Piedmont Sarcoma Group
Publication date
01-11-2010
Publisher
Springer-Verlag
Published in
European Radiology / Issue 11/2010
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-010-1847-y

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