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Journal of Assisted Reproduction and Genetics
Published in: Journal of Assisted Reproduction and Genetics 2/2017

01-02-2017 | Editor’s Commentary

Explaining the futility of the reproductive process in humans: past, present, and future

Author: David F. Albertini

Published in: Journal of Assisted Reproduction and Genetics | Issue 2/2017

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Excerpt

What proportions of conceptions succumb to the hazards of intrauterine development before a viable state is achieved?....and what are the hazards which cause this conceptional deficit? What moiety of the total have intrinsic, geneic or other, inevitable seeds of destruction in the fertilized gamete and what fraction succumb to an inhospitable or hostile intrauterine environment?
E.T. Engle, 1953
…
Literature
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Boklage CE. Survival probability of human conceptions from fertilization to term. Int J Fertil. 1990;35(2):75, 9–80, 1–94.
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Hardy K, Hardy PJ, Jacobs PA, Lewallen K, Hassold TJ. Temporal changes in chromosome abnormalities in human spontaneous abortions: results of 40 years of analysis. Am J Med Genet A. 2016;170(10):2671–80.CrossRefPubMed
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Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR, et al. Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structure. J Assist Reprod Genet. 2014;31(11):1501–9.CrossRefPubMedPubMedCentral
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Werner M, Reh A, Grifo J, Perle MA. Characteristics of chromosomal abnormalities diagnosed after spontaneous abortions in an infertile population. J Assist Reprod Genet. 2012;29(8):817–20.CrossRefPubMedPubMedCentral
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Haig D. Maternal-fetal conflict, genomic imprinting and mammalian vulnerabilities to cancer. Philos Trans R Soc Lond Ser B Biol Sci. 2015;370(1673).
Metadata
Title
Explaining the futility of the reproductive process in humans: past, present, and future
Author
David F. Albertini
Publication date
01-02-2017
Publisher
Springer US
Published in
Journal of Assisted Reproduction and Genetics / Issue 2/2017
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-017-0878-6

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