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Journal of Diabetes & Metabolic Disorders
Published in: Journal of Diabetes & Metabolic Disorders 2/2020

01-12-2020 | Research article

Evaluation of the anti-inflammatory and antioxidant effects of the microalgae Nannochloropsis gaditana in streptozotocin-induced diabetic rats

Authors: Wassila Nacer, Fatima Zohra Baba Ahmed, Hafida Merzouk, Ouahiba Benyagoub, Samira Bouanane

Published in: Journal of Diabetes & Metabolic Disorders | Issue 2/2020

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Abstract

Purpose

This study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats.

Methods

Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined.

Results

It was notice that levels of glucose, glycated hemoglobin (HbA1c), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly (P < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. N. gaditana supplementation was shown effective in lowering the levels of glucose, HbA1c and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats.

Conclusion

N. gaditana possesses antioxidant properties that might have beneficial effect in treatment of diabetes.
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Metadata
Title
Evaluation of the anti-inflammatory and antioxidant effects of the microalgae Nannochloropsis gaditana in streptozotocin-induced diabetic rats
Authors
Wassila Nacer
Fatima Zohra Baba Ahmed
Hafida Merzouk
Ouahiba Benyagoub
Samira Bouanane
Publication date
01-12-2020
Publisher
Springer International Publishing
Published in
Journal of Diabetes & Metabolic Disorders / Issue 2/2020
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-020-00681-3

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