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01-09-2011 | Original Paper

Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease

Authors: Pollyana Feldhaus, Daiane B. Fraga, Fernando V. Ghedim, Renata D. De Luca, Thiago D. Bruna, Matheus Heluany, Maria Paula Matos, Gabriela K. Ferreira, Isabela C. Jeremias, Claudia Heluany, Emilio L. Streck, Alexandra I. Zugno

Published in: Metabolic Brain Disease | Issue 3/2011

Abstract

Alzheimer disease (AD) is a progressive neurodegenerative disease associated with cognitive impairment in multiple domains, such as memory and executive functions. Studies reveal damage in the electron transport chain of patients with AD, suggesting that this mitochondrial dysfunction plays an important role in the pathophysiology of the disease. Blood samples were taken from patients with AD (n = 20) and older subjects without dementia (n = 40) to evaluate the activity of complexes I, II, II–III, and IV of the mitochondrial respiratory chain in isolated lymphocytes. Results from the patient and control groups were compared. The activity of complexes II and IV was increased among patients compared to the control group. No significant difference was observed between controls who were not using psychotropic medication and patients. Our findings point out a mechanism of cellular compensation in which the mitochondrial respiratory chain requires an increase in electron transport to supply the energy needed for cellular functioning. Additional studies are needed to better clarify the mechanisms involved in the mitochondrial dynamics of AD.

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Title: Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease
Authors: Pollyana Feldhaus
Daiane B. Fraga
Fernando V. Ghedim
Renata D. De Luca
Thiago D. Bruna
Matheus Heluany
Maria Paula Matos
Gabriela K. Ferreira
Isabela C. Jeremias
Claudia Heluany
Emilio L. Streck
Alexandra I. Zugno
Publication date: 01-09-2011
Publisher: Springer US
Published in: Metabolic Brain Disease / Issue 3/2011
Print ISSN: 0885-7490
Electronic ISSN: 1573-7365
DOI: https://doi.org/10.1007/s11011-011-9253-y

At a glance: The STEP trials

Springer Medicine

Evaluation of respiratory chain activity in lymphocytes of patients with Alzheimer disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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