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European Archives of Oto-Rhino-Laryngology

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01-04-2020 | Estrogens | Laryngology

G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto

Authors: Saime Sagiroglu, Metin Kılınc, Adem Doganer, Nagihan Bilal, Israfil Orhan, Mehmet Akif Kılıc

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2020

Abstract

Objectives

Puberphonia or mutational falsetto (MF) is seen more in males, and hormonal changes are considered to be among the aetiological causes. Therefore, the aim of this study was to investigate the molecules [G protein-coupled oestrogen receptor 1 (GPER-1), aromatase, 17-beta-hydroxysteroid dehydrogenase (17β-HSD), cyclic adenosine monophosphate (cAMP) levels] related to receptors and pathways in patients with MF.

Methods

The study included 30 MF patients and a control group of 30 healthy individuals. Voice recordings were made of the MF patients and acoustic analyses were applied. The serum GPER-1, aromatase, 17β-HSD, cAMP levels and TSH, estradiol, prolactin, progesterone, and testosterone levels were evaluated in venous blood samples.

Results

In the MF patients, the GPER-1 level determined of mean 3.68 (1.95–4.26) pg/ml, 17 beta dehydrogenase of 5.25 (2.73–6.77) ng/ml, and cAMP of 24.62 (11.62–30.35) ng/ml were statistically signficantly higher than those of the control group (p = 0.008, p = 0.002, p = 0.003, respectively). The aromatase level in the MF patients was found to be 3.48 (2.01–4.91) and the difference between the two groups was not statistically significant (p = 0.067).

Conclusion

The GPER-1, 17β-HSD, and cAMP levels were found to be higher in the MF patients than in the control group, suggesting that they could be of importance in the diagnosis and treatment of MF.

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Title: G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto
Authors: Saime Sagiroglu
Metin Kılınc
Adem Doganer
Nagihan Bilal
Israfil Orhan
Mehmet Akif Kılıc
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Estrogens
Estradiol
Testosterone
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-05795-1

At a glance: The STEP trials

Springer Medicine

G protein coupled oestrogen receptor 1, aromatase, 17β-HSD and cAMP level in mutational falsetto

Abstract

Objectives

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objectives

Methods

Results

Conclusion

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