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European Archives of Oto-Rhino-Laryngology

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01-04-2020 | Propranolol | Otology

Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug

Authors: E. Domínguez-Durán, M. A. Montilla-Ibáñez, M. G. Álvarez-Morujo de Sande, E. Domènech-Vadillo, C. Bécares-Martínez, R. González-Aguado, G. Guerra-Jiménez

Published in: European Archives of Oto-Rhino-Laryngology | Issue 4/2020

Abstract

Introduction

Vestibular migraine (VM) consists of recurrent episodes of vestibular symptoms that are accompanied by migraine in at least 50% of the episodes. The criteria of the Bárány Society include two diagnostic categories: “actual” vestibular migraine and probable vestibular migraine. There is a wide range of drugs that can be prescribed for the prophylactic treatment of VM, but recommendations for the selection of the most appropriate drug are currently lacking.

Objective

To measure the extent to which the prophylactic treatment of VM reduces vestibular symptoms, headache and the number of crises depending on the diagnostic category of the Bárány Society and the drug used for prophylaxis.

Material and methods

This is a multicenter prospective study. Patients with VM who presented to any of the participating centers and who subsequently met the VM criteria were prescribed one of the following types of prophylaxis: acetazolamide, amitriptyline, flunarizine, propranolol or topiramate. Patients were called back for a follow-up visit 5 weeks later. This allowed the intensity of vestibular symptoms, headache and the number of crises before and during treatment to be compared.

Results

31 Patients met the inclusion criteria. During the treatment, all the measured variables decreased significantly. In a visual analogue scale, the intensity of vestibular symptoms decreased by 45.8 points, the intensity of headache decreased by 47.8 points and patients suffered from 15.6 less monthly crises compared to the period before the treatment. No significant between-group differences were found when patients were divided based on their diagnostic category or the choice of prophylaxis prescribed to them.

Conclusion

The treatment of VM produces a reduction of symptoms and crises with no significant differences based on patients’ diagnostic categories or the choice of prophylaxis prescribed to them.

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Title: Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug
Authors: E. Domínguez-Durán
M. A. Montilla-Ibáñez
M. G. Álvarez-Morujo de Sande
E. Domènech-Vadillo
C. Bécares-Martínez
R. González-Aguado
G. Guerra-Jiménez
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Propranolol
Migraine
Benign Paroxysmal Positional Vertigo
Vestibular Migraine
Headache
Amitriptyline
Topiramate
Acetazolamide
Published in: European Archives of Oto-Rhino-Laryngology / Issue 4/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-05802-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Analysis of the effectiveness of the prophylaxis of vestibular migraine depending on the diagnostic category and the prescribed drug

Abstract

Introduction

Objective

Material and methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Objective

Material and methods

Results

Conclusion

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